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Gene: Rnf126 (ring finger protein 126) Rattus norvegicus

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Symbol:

Rnf126

Name:

ring finger protein 126

RGD ID:

1306011

Description:

Predicted to enable epidermal growth factor receptor binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of double-strand break repair via homologous recombination; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human RNF126 (ring finger protein 126); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 4,4'-sulfonyldiphenol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

E3 ubiquitin-protein ligase RNF126; LOC314613; MGC124770

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RNF126 (ring finger protein 126)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Rnf126 (ring finger protein 126)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rnf126 (ring finger protein 126)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RNF126 (ring finger protein 126)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RNF126 (ring finger protein 126)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	LOC101961559 (E3 ubiquitin-protein ligase RNF126)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RNF126 (ring finger protein 126)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RNF126 (ring finger protein 126)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rnf126 (ring finger protein 126)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	RNF126 (ring finger protein 126)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rnf126 (ring finger protein 126)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rnf126 (ring finger protein 126)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG11982	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	Y54E10BR.3	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rnf126	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	10,590,013 - 10,597,585 (+)	NCBI		GRCr8
mRatBN7.2	7	9,939,359 - 9,946,963 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	9,938,229 - 9,946,738 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	12,820,464 - 12,827,752 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	14,698,545 - 14,705,833 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	12,557,874 - 12,565,162 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	12,820,796 - 12,828,325 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	12,820,840 - 12,828,334 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	12,991,016 - 12,998,529 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	11,454,326 - 11,461,614 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	11,454,379 - 11,461,302 (+)	NCBI
Celera	7	8,112,972 - 8,120,260 (+)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cerebral creatine deficiency syndrome (ISO)

cyclic hematopoiesis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

4,4'-sulfonyldiphenol (EXP)

acetochlor (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bisphenol F (EXP,ISO)

butan-1-ol (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

chlorpyrifos (ISO)

cobalt dichloride (EXP,ISO)

copper atom (ISO)

copper(0) (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

dibutyl phthalate (ISO)

diquat (ISO)

endosulfan (EXP)

ethanol (ISO)

ethyl methanesulfonate (ISO)

flutamide (EXP)

gentamycin (EXP)

glafenine (EXP)

herbicide (ISO)

isobutanol (ISO)

ivermectin (ISO)

methimazole (EXP)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

tamoxifen (ISO)

testosterone (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cytoplasm protein quality control by the ubiquitin-proteasome system (ISO)

negative regulation of epidermal growth factor receptor signaling pathway (ISO)

positive regulation of double-strand break repair via homologous recombination (ISO)

proteasome-mediated ubiquitin-dependent protein catabolic process (ISO)

protein K27-linked ubiquitination (ISO)

protein K29-linked ubiquitination (ISO)

protein K48-linked ubiquitination (ISO)

protein K63-linked ubiquitination (ISO)

protein monoubiquitination (ISO)

protein ubiquitination (IBA)

regulation of cell population proliferation (ISO)

retrograde transport, endosome to Golgi (ISO)

ubiquitin-dependent protein catabolic process (ISO)

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (ISO)

Cellular Component

cytoplasm (IBA,ISO)

cytosol (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (ISO)

Molecular Function

epidermal growth factor receptor binding (ISO)

metal ion binding (IEA)

protein binding (ISO)

ubiquitin protein ligase activity (IBA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:23026136	PMID:23277564	PMID:23418353	PMID:24275455	PMID:24981174	PMID:28383811

Genomics

Comparative Map Data

Rnf126
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	10,590,013 - 10,597,585 (+)	NCBI		GRCr8
mRatBN7.2	7	9,939,359 - 9,946,963 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	9,938,229 - 9,946,738 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	12,820,464 - 12,827,752 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	14,698,545 - 14,705,833 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	12,557,874 - 12,565,162 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	12,820,796 - 12,828,325 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	12,820,840 - 12,828,334 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	12,991,016 - 12,998,529 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	11,454,326 - 11,461,614 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	11,454,379 - 11,461,302 (+)	NCBI
Celera	7	8,112,972 - 8,120,260 (+)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

RNF126
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	647,526 - 663,214 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	647,526 - 663,233 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	647,526 - 663,214 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	598,526 - 614,227 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	19	154,322 - 170,071 (+)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	417,361 - 433,064 (-)	NCBI		HuRef
CHM1_1	19	647,187 - 662,920 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	601,753 - 617,249 (-)	NCBI		T2T-CHM13v2.0

Rnf126
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	79,594,349 - 79,607,282 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	79,594,349 - 79,602,786 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	79,758,515 - 79,771,448 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	79,758,515 - 79,766,952 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	79,221,260 - 79,229,686 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	79,161,668 - 79,170,053 (-)	NCBI		MGSCv36	mm8
Celera	10	80,773,108 - 80,791,932 (-)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.72	NCBI

Rnf126
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	7,095,336 - 7,102,757 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	7,083,952 - 7,098,442 (+)	NCBI	ChiLan1.0	ChiLan1.0

RNF126
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	4,969,822 - 4,988,575 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	4,211,553 - 4,226,693 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	491,699 - 494,175 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1 Ensembl	19	614,236 - 618,659 (-)	Ensembl	panpan1.1		panPan2

RNF126
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	57,890,333 - 57,899,364 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	57,891,413 - 57,898,863 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	57,694,175 - 57,701,870 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	58,634,727 - 58,642,433 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	58,634,192 - 58,642,215 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	57,688,864 - 57,696,560 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	58,168,322 - 58,176,002 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	58,371,682 - 58,379,389 (+)	NCBI		UU_Cfam_GSD_1.0

LOC101961559
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	217,572,863 - 217,603,060 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	229,508 - 237,969 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0 Ensembl	NW_004936588	255,639 - 260,291 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	231,723 - 237,969 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RNF126
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	77,673,353 - 77,683,311 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	77,673,302 - 77,683,312 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

RNF126
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	392,717 - 409,139 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666081	8,561,985 - 8,593,924 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rnf126
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	7,856,470 - 7,869,926 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624828	7,856,822 - 7,865,644 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Rnf126
13 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	162
Count of miRNA genes:	117
Interacting mature miRNAs:	132
Transcripts:	ENSRNOT00000012317
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	44782185	Rat
1300176	Hrtrt10	Heart rate QTL 10	3.19		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	664270	26029351	Rat
9590102	Sffal5	Serum free fatty acids level QTL 5	8.62	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	7	5329019	50329019	Rat
1578652	Bmd15	Bone mineral density QTL 15	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	7	9866467	60460686	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	9462246	98011544	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1	44822433	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
10755438	Coatc9	Coat color QTL 9		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	3529280	48529280	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	31962314	Rat
2298547	Neuinf5	Neuroinflammation QTL 5	3.7		nervous system integrity trait (VT:0010566)	spinal cord Cd74 protein level (CMO:0002131)	7	9462246	58265113	Rat
10059592	Kidm45	Kidney mass QTL 45	3.95	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	7573985	52573985	Rat
2317047	Wbc4	White blood cell count QTL 4		0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	7	1	35342956	Rat
10755440	Coatc10	Coat color QTL 10		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	7496499	52496499	Rat
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	27829089	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34000259	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	31962314	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001033702	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006240899	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017594811	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063263409	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC099810	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000012317 ⟹ ENSRNOP00000012317

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	9,938,229 - 9,946,738 (+)	Ensembl
Rnor_6.0 Ensembl	7	12,820,840 - 12,828,334 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000114773 ⟹ ENSRNOP00000096321

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	9,938,229 - 9,946,511 (+)	Ensembl

RefSeq Acc Id:

NM_001033702 ⟹ NP_001028874

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	10,590,072 - 10,597,360 (+)	NCBI
mRatBN7.2	7	9,939,450 - 9,946,738 (+)	NCBI
Rnor_6.0	7	12,820,812 - 12,828,100 (+)	NCBI
Rnor_5.0	7	12,991,016 - 12,998,529 (+)	NCBI
RGSC_v3.4	7	11,454,326 - 11,461,614 (+)	RGD
Celera	7	8,112,972 - 8,120,260 (+)	RGD

Sequence:

show sequence

GCAAACGGCCGGCGGCAGGCGCCGCGCGGGGGGCGGGCGGCGCGGAGGCGGCGGTGGCCATGGC
TGAGGCGTCGCCGCAGCCCGGACGGTACTTCTGCCACTGCTGTTCGGTGGAGATCGTGCCGCGC
CTGCCGGATTACATCTGCCCACGGTGCGAGTCTGGCTTCATCGAGGAGCTTCCAGAAGAGACCA
GGAACACAGAAAACGGCTCAGCCCCCTCCACAGCCCCTACTGACCAGAACCGGCAGCCATTTGA
GGTGCGTCAGGGTCCCTGGGCCCAGGCCCGCCCTCCTGTCCTGCAGAATGTGGACCAGCACCTG
TTCACGCTGCCACAGGGATACAGCCAGTTTGCTTTTGGCATCTTCGACGACAGCTTTGAGATTC
CTGCGTTCCCTCCTGGGGCCCAGGCCGATGATGGCAGGGACCCTGAGAGCCGACGGGAGAGAGA
GCATCAGTCTCGGCATCGGTATGGGGCCCGGCAGCCCCGTGCCCGCCTCACTGCCCGGCGGGCC
ACTGGCCGGCATGAAGGCGTCCCCACGCTGGAAGGGATCATCCAGCAGCTCGTGAATGGCATCA
TCTCTCCAGCTGCCGTACCCAGCCTGGGCCTTGGTCCCTGGGGCGTCCTGCACTCGAACCCAAT
GGACTACGCCTGGGGGGCCAACGGCCTGGACGCCATCATCACGCAGCTCCTCAATCAGTTTGAG
AACACCGGCCCCCCACCTGCAGACAAGGAGAAGATTCAGGCTCTCCCCACGGTCCCAGTCACAG
AGGAGCACGTGGGCTCAGGGCTGGAGTGCCCAGTGTGCAAAGAAGACTACGCGCTGGGTGAGAG
AGTGCGGCAGTTACCCTGCAACCACCTGTTCCACGACAGCTGCATCGTGCCCTGGCTGGAGCAG
CATGACAGCTGCCCGGTCTGCCGCAAGAGCCTCACTGGACAGAACACAGCCACCAATCCTCCAG
GCCTGACCGGTGTTGGCTTCTCCTCGTCCTCGTCCTCATCCTCGTCCAGCTCACCCAGCAACGA
GAACGCCACAAGCAACTCCTGAGTCCCACCTGGCCATCCCCCCGGGGCTTGGTCATCCCACCCA
CCCCAGGTGCCCCAGCACCGCCTGCCATGGCCGTGGACTAGAGGTGCTGCCCATGGCGGCCGGC
AGCACCTGGCGGGCCCCAGGCTGCGGGCGGCTCGGACTTGGCCATGGCCGCTCCTGTTTGGAGG
TGTGCACGTGGGTCCCATGTCCCCAGCAGGCAGGCGCCTTCAGTCCGTCTTTAACCTCACCCTC
CAAATGTTCAACGGCAGAAGGGTTTTTATGATTTTAAATTATTACTGCTTTGAAATAAATGGAC
GTTTGAGCCACGTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006240899 ⟹ XP_006240961

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	10,590,026 - 10,597,585 (+)	NCBI
mRatBN7.2	7	9,939,389 - 9,946,963 (+)	NCBI
Rnor_6.0	7	12,820,796 - 12,828,325 (+)	NCBI
Rnor_5.0	7	12,991,016 - 12,998,529 (+)	NCBI

Sequence:

show sequence

GGCCGGCGAGGGAGCAGCAAACGGCCGGCGGCAGGCGCCGCGCGGGGGGCGGGCGGCGCGGAGG
CGGCGGTGGCCATGGCTGAGGCGTCGCCGCAGCCCGGACGGTACTTCTGCCACTGCTGTTCGGT
GGAGATCGTGCCGCGCCTGCCGGATTACATCTGCCCACGGTGCGAGTCTGGCTTCATCGAGGAG
CTTCCAGAAGAGACCAGGAACACAGAAAACGGCTCAGCCCCCTCCACAGCCCCTACTGACCAGA
ACCGGCAGCCATTTGAGAATGTGGACCAGCACCTGTTCACGCTGCCACAGGGATACAGCCAGTT
TGCTTTTGGCATCTTCGACGACAGCTTTGAGATTCCCGCGTTCCCTCCTGGGGCCCAGGCCGAT
GATGGCAGGGACCCTGAGAGCCGACGGGAGAGAGAGCACCAGTCTCGGCATCGGTATGGGGCCC
GGCAGCCCCGTGCCCGCCTCACTGCCCGGCGGGCCACTGGCCGGCATGAAGGCGTCCCCACGCT
GGAAGGGATCATCCAGCAGCTCGTGAATGGCATCATCTCTCCAGCTGCCGTACCCAGCCTGGGC
CTTGGTCCCTGGGGCGTCCTGCACTCGAACCCAATGGACTACGCCTGGGGGGCCAACGGCCTGG
ACGCCATCATCACGCAGCTCCTCAATCAGTTTGAGAACACCGGCCCCCCACCTGCAGACAAGGA
GAAGATTCAGGCTCTCCCCACGGTCCCAGTCACAGAGGAGCACGTGGGCTCAGGGCTGGAGTGC
CCAGTGTGCAAAGAAGACTACGCGCTGGGTGAGAGAGTGCGGCAGTTACCCTGCAACCACCTGT
TCCACGACAGCTGCATCGTGCCCTGGCTGGAGCAGCATGACAGCTGCCCGGTCTGCCGCAAGAG
CCTCACTGGACAGAACACAGCCACCAATCCTCCAGGCCTGACCGGTGTTGGCTTCTCCTCGTCC
TCGTCCTCATCCTCGTCCAGCTCACCCAGCAACGAGAACGCCACAAGCAACTCCTGAGTCCCAC
CTGGCCATCCCCCCGGGGCTTGGTCATCCCACCCACCCCAGGTGCCCCAGCACCGCCTGCCATG
GCCGTGGACTAGAGGTGCTGCCCATGGCGGCCGGCAGCACCTGGCGGGCCCCAGGCTGCGGGCG
GCTCGGACTTGGCCATGGCCGCTCCTGTTTGGAGGTGTGCACGTGGGTCCCATGTCCCCAGCAG
GCAGGCGCCTTCAGTCCGTCTTTAACCTCACCCTCCAAATGTTCAACGGCAGAAGGGTTTTTAT
GATTTTAAATTATTACTGCTTTGAAATAAATGGACGTTTGAGCCACGTGCGGCCATGCATGATC
TGTGGAGAGTCAGCAGAACTGTCGCCAGGCCCAGCCCGCCACATGCCCTGGGAGGCCGGGCCAG
CACCCAGTCAGCGCCGGCCTCGGGACCACGAGGGTGACCAGCAGACCCAGGAACAAACTGCTCC
AGCAGACATTTTTTTTTTTTTTTTTAAGGGAAATGTGTGTTATCTGGAAAGCTATTTAAAATAC
ACCTACTCAAAAAGCAGA

hide sequence

RefSeq Acc Id:

XM_017594811 ⟹ XP_017450300

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	10,590,013 - 10,597,585 (+)	NCBI
mRatBN7.2	7	9,939,359 - 9,946,963 (+)	NCBI
Rnor_6.0	7	12,820,796 - 12,828,325 (+)	NCBI

Sequence:

show sequence

GGCCGGCGAGGGAGCAGCAAACGGCCGGCGGCAGGCGCCGCGCGGGGGGCGGGCGGCGCGGAGG
CGGCGGTGGCCATGGCTGAGGCGTCGCCGCAGCCCGGACGGTACTTCTGCCACTGCTGTTCGGT
GGAGATCGTGCCGCGCCTGCCGGATTACATCTGCCCACGGTGCGAGTCTGGCTTCATCGAGGAG
CTTCCAGAAGAGACCAGGAACACAGAAAACGGCTCAGCCCCCTCCACAGCCCCTACTGACCAGA
ACCGGCAGCCATTTGAGGTGCGTCAGGGTCCCTGGGCCCAGGCCCGCCCTCCTGTCCTGCAGAA
TGTGGACCAGCACCTGTTCACGCTGCCACAGGGATACAGCCAGTTTGCTTTTGGCATCTTCGAC
GACAGCTTTGAGATTCCCGCGTTCCCTCCTGGGGCCCAGGCCGATGATGGCAGGGACCCTGAGA
GCCGACGGGAGAGAGAGCACCAGTCTCGGCATCGGTATGGGGCCCGGCAGCCCCGTGCCCGCCT
CACTGCCCGGCGGGCCACTGGCCGGCATGAAGGCGTCCCCACGCTGGAAGGGATCATCCAGCAG
CTCGTGAATGGCATCATCTCTCCAGCTGCCGTACCCAGCCTGGGCCTTGGTCCCTGCTCCTCAA
TCAGTTTGAGAACACCGGCCCCCCACCTGCAGACAAGGAGAAGATTCAGGCTCTCCCCACGGTC
CCAGTCACAGAGGAGCACGTGGGCTCAGGGCTGGAGTGCCCAGTGTGCAAAGAAGACTACGCGC
TGGGTGAGAGAGTGCGGCAGTTACCCTGCAACCACCTGTTCCACGACAGCTGCATCGTGCCCTG
GCTGGAGCAGCATGACAGCTGCCCGGTCTGCCGCAAGAGCCTCACTGGACAGAACACAGCCACC
AATCCTCCAGGCCTGACCGGTGTTGGCTTCTCCTCGTCCTCGTCCTCATCCTCGTCCAGCTCAC
CCAGCAACGAGAACGCCACAAGCAACTCCTGAGTCCCACCTGGCCATCCCCCCGGGGCTTGGTC
ATCCCACCCACCCCAGGTGCCCCAGCACCGCCTGCCATGGCCGTGGACTAGAGGTGCTGCCCAT
GGCGGCCGGCAGCACCTGGCGGGCCCCAGGCTGCGGGCGGCTCGGACTTGGCCATGGCCGCTCC
TGTTTGGAGGTGTGCACGTGGGTCCCATGTCCCCAGCAGGCAGGCGCCTTCAGTCCGTCTTTAA
CCTCACCCTCCAAATGTTCAACGGCAGAAGGGTTTTTATGATTTTAAATTATTACTGCTTTGAA
ATAAATGGACGTTTGAGCCACGTGCGGCCATGCATGATCTGTGGAGAGTCAGCAGAACTGTCGC
CAGGCCCAGCCCGCCACATGCCCTGGGAGGCCGGGCCAGCACCCAGTCAGCGCCGGCCTCGGGA
CCACGAGGGTGACCAGCAGACCCAGGAACAAACTGCTCCAGCAGACATTTTTTTTTTTTTTTTT
AAGGGAAATGTGTGTTATCTGGAAAGCTATTTAAAATACACCTACTCAAAAAGCAGA

hide sequence

RefSeq Acc Id:

XM_063263409 ⟹ XP_063119479

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	10,590,023 - 10,597,585 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001028874	(Get FASTA)	NCBI Sequence Viewer
	XP_006240961	(Get FASTA)	NCBI Sequence Viewer
	XP_017450300	(Get FASTA)	NCBI Sequence Viewer
	XP_063119479	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH99810	(Get FASTA)	NCBI Sequence Viewer
	EDL89396	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000012317.6
	ENSRNOP00000096321.1

RefSeq Acc Id:

NP_001028874 ⟸ NM_001033702

- UniProtKB:

Q499Q1 (UniProtKB/TrEMBL), F7ESD4 (UniProtKB/TrEMBL), A0A8I6GM09 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAEASPQPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEETRNTENGSAPSTAPTDQNRQP
FEVRQGPWAQARPPVLQNVDQHLFTLPQGYSQFAFGIFDDSFEIPAFPPGAQADDGRDPESRRE
REHQSRHRYGARQPRARLTARRATGRHEGVPTLEGIIQQLVNGIISPAAVPSLGLGPWGVLHSN
PMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKEDYALG
ERVRQLPCNHLFHDSCIVPWLEQHDSCPVCRKSLTGQNTATNPPGLTGVGFSSSSSSSSSSSPS
NENATSNS

hide sequence

RefSeq Acc Id:	XP_006240961 ⟸ XM_006240899
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6GM09 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAEASPQPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEETRNTENGSAPSTAPTDQNRQP FENVDQHLFTLPQGYSQFAFGIFDDSFEIPAFPPGAQADDGRDPESRREREHQSRHRYGARQPR ARLTARRATGRHEGVPTLEGIIQQLVNGIISPAAVPSLGLGPWGVLHSNPMDYAWGANGLDAII TQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKEDYALGERVRQLPCNHLFHDS CIVPWLEQHDSCPVCRKSLTGQNTATNPPGLTGVGFSSSSSSSSSSSPSNENATSNS hide sequence

RefSeq Acc Id:

XP_017450300 ⟸ XM_017594811

- Peptide Label:

isoform X2

- Sequence:

show sequence

MAEASPQPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEETRNTENGSAPSTAPTDQNRQP
FEVRQGPWAQARPPVLQNVDQHLFTLPQGYSQFAFGIFDDSFEIPAFPPGAQADDGRDPESRRE
REHQSRHRYGARQPRARLTARRATGRHEGVPTLEGIIQQLVNGIISPAAVPSLGLGPCSSISLR
TPAPHLQTRRRFRLSPRSQSQRSTWAQGWSAQCAKKTTRWVRECGSYPATTCSTTAASCPGWSS
MTAARSAARASLDRTQPPILQA

hide sequence

Ensembl Acc Id:

ENSRNOP00000012317 ⟸ ENSRNOT00000012317

Ensembl Acc Id:

ENSRNOP00000096321 ⟸ ENSRNOT00000114773

RefSeq Acc Id:	XP_063119479 ⟸ XM_063263409
- Peptide Label:	isoform X3

Protein Domains

E3 ubiquitin-protein ligase RNF126-like zinc-ribbon RING-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F7ESD4-F1-model_v2	AlphaFold	F7ESD4	1-313	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695053

Promoter ID:

EPDNEW_R5577

Type:

initiation region

Name:

Rnf126_1

Description:

ring finger protein 126

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	12,820,811 - 12,820,871	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306011	AgrOrtholog
BioCyc Gene	G2FUF-34887	BioCyc
Ensembl Genes	ENSRNOG00000009028	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000012317.7	UniProtKB/TrEMBL
	ENSRNOT00000114773.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.40.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:5621533	IMAGE-MGC_LOAD
InterPro	RNF126-like_zinc-ribbon	UniProtKB/TrEMBL
	RNF126_RING-H2	UniProtKB/TrEMBL
	Znf_RING	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
KEGG Report	rno:314613	UniProtKB/TrEMBL
MGC_CLONE	MGC:124770	IMAGE-MGC_LOAD
NCBI Gene	314613	ENTREZGENE
PANTHER	E3 UBIQUITIN-PROTEIN LIGASE PRAJA	UniProtKB/TrEMBL
	PTHR15710:SF21	UniProtKB/TrEMBL
Pfam	zf-RING_2	UniProtKB/TrEMBL
	zinc_ribbon_9	UniProtKB/TrEMBL
PhenoGen	Rnf126	PhenoGen
PROSITE	ZF_RING_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000009028	RatGTEx
SMART	RING	UniProtKB/TrEMBL
Superfamily-SCOP	RING/U-box	UniProtKB/TrEMBL
UniProt	A0A8I6GM09	ENTREZGENE, UniProtKB/TrEMBL
	A6K8X6_RAT	UniProtKB/TrEMBL
	F7ESD4	ENTREZGENE
	Q499Q1	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	F7ESD4	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Rnf126	ring finger protein 126	Rnf126_predicted	ring finger protein 126 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Rnf126_predicted	ring finger protein 126 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar