Slf1 (SMC5-SMC6 complex localization factor 1)

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Gene: Slf1 (SMC5-SMC6 complex localization factor 1) Rattus norvegicus

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Symbol:

Slf1

Name:

SMC5-SMC6 complex localization factor 1

RGD ID:

1304857

Description:

Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including positive regulation of cellular component organization; positive regulation of double-strand break repair; and protein localization to site of double-strand break. Predicted to be located in centrosome; cytoplasm; and nucleus. Predicted to be part of nucleosome. Predicted to be active in nucleus and site of double-strand break. Orthologous to human SLF1 (SMC5-SMC6 complex localization factor 1); INTERACTS WITH bisphenol A; cadmium dichloride; Cuprizon.

Type:

protein-coding (Ensembl: pseudogene)

RefSeq Status:

PROVISIONAL

Previously known as:

Ankrd32; ankyrin repeat domain 32; ankyrin repeat domain-containing protein 32; LOC294601; SMC5-SMC6 complex localization factor protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	8,498,776 - 8,606,251 (-)	NCBI		GRCr8
mRatBN7.2	2	6,767,015 - 6,874,428 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	6,767,015 - 6,867,149 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	13,879,067 - 13,986,283 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	11,978,347 - 12,085,564 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	6,613,410 - 6,719,621 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	4,095,126 - 4,195,819 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	4,095,129 - 4,195,810 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	4,092,109 - 4,193,740 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	4,361,776 - 4,469,805 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	4,436,397 - 4,492,122 (-)	NCBI
Celera	2	3,225,433 - 3,326,221 (-)	NCBI		Celera
Cytogenetic Map	2	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

familial adenomatous polyposis 1 (ISO)

Hereditary Neoplastic Syndromes (ISO)

Neurodevelopmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-methylcholine (ISO)

4-hydroxyphenyl retinamide (ISO)

aflatoxin B1 (ISO)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

azathioprine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP)

CGP 52608 (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

Enterolactone (ISO)

ethyl methanesulfonate (ISO)

maneb (ISO)

methyl methanesulfonate (ISO)

N-methyl-4-phenylpyridinium (ISO)

nickel atom (ISO)

ozone (ISO)

paracetamol (ISO)

paraquat (ISO)

phenylmercury acetate (ISO)

potassium chromate (ISO)

quinolin-8-ol (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

succimer (ISO)

sulforaphane (ISO)

sunitinib (ISO)

temozolomide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA damage response (ISO)

positive regulation of double-strand break repair (ISO)

positive regulation of maintenance of mitotic sister chromatid cohesion (ISO)

positive regulation of protein-containing complex assembly (ISO)

protein localization to site of double-strand break (ISO)

Cellular Component

centrosome (ISO)

cytoplasm (ISO)

nuclear inclusion body (ISO)

nucleoplasm (ISO)

nucleosome (ISO)

nucleus (ISO)

site of double-strand break (ISO)

Molecular Function

protein binding (ISO)

protein-containing complex binding (ISO)

ubiquitin protein ligase binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15632077	PMID:21873635	PMID:22036607	PMID:25931565

Genomics

Comparative Map Data

Slf1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	8,498,776 - 8,606,251 (-)	NCBI		GRCr8
mRatBN7.2	2	6,767,015 - 6,874,428 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	6,767,015 - 6,867,149 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	13,879,067 - 13,986,283 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	11,978,347 - 12,085,564 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	6,613,410 - 6,719,621 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	4,095,126 - 4,195,819 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	4,095,129 - 4,195,810 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	4,092,109 - 4,193,740 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	4,361,776 - 4,469,805 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	4,436,397 - 4,492,122 (-)	NCBI
Celera	2	3,225,433 - 3,326,221 (-)	NCBI		Celera
Cytogenetic Map	2	q11	NCBI

SLF1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	94,618,231 - 94,697,621 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	94,618,669 - 94,739,436 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	93,954,374 - 94,033,326 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	94,040,330 - 94,057,338 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	94,040,329 - 94,057,110	NCBI
Celera	5	89,816,284 - 89,893,469 (+)	NCBI		Celera
Cytogenetic Map	5	q15	NCBI
HuRef	5	89,127,664 - 89,204,854 (+)	NCBI		HuRef
CHM1_1	5	93,387,020 - 93,464,202 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	95,098,399 - 95,182,005 (+)	NCBI		T2T-CHM13v2.0

Slf1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	77,191,207 - 77,283,632 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	77,191,207 - 77,283,592 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	77,043,088 - 77,135,513 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	77,043,088 - 77,135,473 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	77,182,349 - 77,274,729 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	77,506,638 - 77,554,806 (-)	NCBI		MGSCv36	mm8
Celera	13	79,368,270 - 79,463,257 (-)	NCBI		Celera
Cytogenetic Map	13	C1	NCBI
cM Map	13	40.98	NCBI

Slf1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955418	17,756,861 - 17,810,663 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955418	17,756,610 - 17,818,552 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLF1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	20,684,529 - 20,782,033 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	18,838,281 - 18,935,816 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	20,660,101 - 20,757,072 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	20,817,614 - 20,894,427 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	20,817,614 - 20,884,453 (-)	Ensembl	panpan1.1		panPan2

SLF1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	14,792,851 - 14,877,024 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	14,793,363 - 14,869,755 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	16,131,131 - 16,215,470 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	14,672,489 - 14,756,866 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	14,670,381 - 14,744,679 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	14,635,334 - 14,719,686 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	14,633,850 - 14,718,174 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	14,837,537 - 14,921,894 (-)	NCBI		UU_Cfam_GSD_1.0

Slf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	170,378,075 - 170,449,166 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936523	8,563,410 - 8,634,585 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936523	8,563,662 - 8,634,576 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLF1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	101,313,091 - 101,375,607 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	101,286,744 - 101,375,612 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	104,867,972 - 104,919,338 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLF1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	88,497,787 - 88,573,966 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	88,499,373 - 88,576,983 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666049	37,141,458 - 37,236,741 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slf1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624743	13,337,785 - 13,395,618 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624743	13,327,544 - 13,394,434 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Slf1
266 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	259
Count of miRNA genes:	166
Interacting mature miRNAs:	188
Transcripts:	ENSRNOT00000018457
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
738010	Lnnr3	Liver neoplastic nodule remodeling QTL 3	2.94		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	2	1	41244106	Rat
631682	Bp115	Blood pressure QTL 115	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	1	37410502	Rat
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	5873687	102844969	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106400	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008760599	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063281458	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063281459	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010063587	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC097940	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473955	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230728	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000018457 ⟹ ENSRNOP00000018457

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	6,767,015 - 6,867,149 (-)	Ensembl
Rnor_6.0 Ensembl	2	4,095,129 - 4,195,810 (-)	Ensembl

RefSeq Acc Id:

NM_001106400 ⟹ NP_001099870

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	8,498,778 - 8,606,223 (-)	NCBI
mRatBN7.2	2	6,767,015 - 6,874,428 (-)	NCBI
Rnor_6.0	2	4,095,131 - 4,195,819 (-)	NCBI
Rnor_5.0	2	4,092,109 - 4,193,740 (-)	NCBI
RGSC_v3.4	2	4,361,776 - 4,469,805 (-)	RGD
Celera	2	3,225,433 - 3,326,221 (-)	RGD

Sequence:

show sequence

AGAACCCAGATTATTGGAGCTGTGAGTACTACCGTGGTAGTCTTCGCCCTACCGCCGCCACCGG
CAGCGCCACACGAAGAAAACAGCCCTGAAGTTTCTTTCAGCCGGGAAGATGGAAGGTGGTGCCA
CCAAACATGTCATCCAGATGACAGGGTTTAAGATGGAGGAGAAGGAAGCTCTAGTCAAGTTGCT
TTTAAAGCTAGATTGCACTTTTATAAAGAGTGAGAAATATAAAAACTGTACACATCTTATAGCT
GAACGCCTGTGCAAGAGTGAGAAGTTTTTAGCAGCTTGTGCTGCAGGAAAATGGGTATTAACAA
AGGATTACATAATTCATAGTGCCAAAAGTGGCAGATGGCTTGATGAAACAACTTATGAATGGGG
ATATAAAATTGAAAAAGATTCCCATTATTCACCTCAAATGCAATCTGCACCGAAAAGATGGCGT
GAAGAGCTGAAACGGACTGGTGCTCCTGGAGCCTTCCACAGATGGAAAGTTGTTCTCCTTGTTA
GGGCAGATAAGCGGAGTGACTCTCTTGTAAGAGTTTTGGAAGCTGGAAAGGCAAATGTCATTTT
ACCAAGAAGTTCTCCTAGTGGTATAACCCATGTGATTGCCAGTAATGCAAGAATCAGTGCTGAG
AGAGAACAAGAAAACTTTAAGGCTCCGTTTTATCCAATTCAGTATTTAGGGGATTTTCTCTTAG
AGAAAGAAATTCAGAATGATGAAGATTCCCAAATCAGTTCTGGTCGGACCAAATATAACAGTCA
AGAAAAAAGCAAAGATTTTAAGAGAGACATGGGATTTCTTGAAATGAAAGGTGCTGGAGAAAAC
ATGTACAGAACTCAGAATAAAATGGGAAATCATAATGAAAATGTTAATGATAAGTTTGTTCTGA
GTGAACATCACAAAAAGAAATTCAGAGACTTCAGAAAAGATATGAAATCTATTAAAAAAACAAA
TACATTCAGAAGACGTGCACATGAGAATCAGAAAGAAACTAAGAAAAAAGATAAAAATGTCCAA
AGGAGTTACATTTTAAGGAAAAAGAACATAAAAGAAGGTTATTGCAAAACTGACGATGCCCATG
ACACAACTAGAAGTACATTAAAAAAGCGCTGGAGCTACAGAGACCAGAAAGAAATGAAGAATTC
TCTTCTTACTGATTGTGCCAAAGAATCAGAGACCAAGGATGTCAAGGCAAATGTGGATCTCACG
GAAGTAAAAAATGCCTTAAAGAGGCAGATACACAGAGACATATATAGAGCTCAGGCAGTCCGAT
ACAACTGCATTAGAGTAGATAAACAGCCGGTATACAATGTAGAGGTTAAAAATGCAGAGTTCCC
CAGAGGAATATTAAATTTAATTGAAAGCCTCATAGAGGGACAGTTCTTTAAAGAAGCCATTGAA
GAGCTTTCCTCTTTGCAAGCCCATTATGTCCCTCCAGTGTGCCTTCTACATGCCCTACTAGAGA
ATGTTCTGCAGGATAATATAGATACATTTTCTGGTCGATACTTTCATATATTATCAGCTCTTCT
TCATCTGCATCCTCCTTGGAAGTCACCAGCCATGTCAAGATACTACTTAGAGCTATTTCAGTGT
CCAACTTGTATGAAAGGAGCCTGGCCTCTCGTGGAGATGCTCGTCAGGTCTTGTCTTTTCAATG
AAGGTTTCTGCCATCAAATATCAGAAAACATTGGTTCTAAAGTGGCCCATCTTACACTGCTCAA
GTTCTTCTTTAACCTACTTGAAAGTGAAGTGCGGCATTTGAGTCAAAAGTTATGTGACTGGTCA
GATTCTCAGAATCTAAAAGTAGCAGAAAAGGCAATTCTTCATGAAATTTTTTGGTCAGGAAGTG
AAACTTCAGGACTTTTGACAAAACCAGTAAATATGCTTTTGGAATGGACTATTTATTCTCACAA
GGAAAAATGCAAGTCTAATGATGTCTTCAAACATGAACTATCTTACTTACTGACTGGAATTCTT
GGCACAGCAGTAGACTATTGGATCTTCCTTGGTATTCAGATGGGTAGAAATGTGATCCGACACA
TGTCTGAGGACTTAGGAAGCTATATTTCCCTTTCCTGTGATGACTTTTCTTCAAAAGAACTAGA
GCTCTTCATTTGTTCCTTTTCATCTTCCTGGCTTCAAATGTTCGTTGCAGAAGCAATCTTTAAA
AAGCTGTGCTTACAGGGCCCCACTAGTACGTGCACTGAGCCACTCTCTCTTCAGAAAATAATAG
ATTCCTATTTACCAGTTTTGGGGAAAATGGACATACATGGGGCTGGAAAGATGCAGATGCCAAA
AAAACTCTGCCAGCGGCCTTGCCTAGAGTCTCAAAGAGCGTTACTAATGCTGAACGGTGCAAAA
CAGAAACAAGCAGACGGTCGGCCAGAGTTCCTTGAGTTAAACCATGCTAAATGTTCCTCATCGT
TGAAAAAGCTGAAGAAGAAGTCAGAAGGAGAATCGTCATGTTCGAAGGAGAATTGCCCCTCTTT
GGTTACAAAGATGAATTTTCATAAAACTAATCTGAAAGGGGAAACAGCTCTGCATAGAGTTTGC
ATAAAAAACCAAGTGGAGAAATTGATTATTCTTCTCTCTTTACCAGGAATAGACATCAATGTTA
AAGACAATGCTGGCTGGACGCCTTTGCATGAAGCCTGTAACTATGGCAACACAGTGTGTGTCCG
GGAAATTTTGCAACGTTGTCCAGAGGTAGATCTGCTCACTCAAGTGGACGGGGTGACTCCTTTG
CATGATGCACTGTCAAACGGACATGTAGAAATTGGCAAGCTGCTTCTACAGCATGGGGGCCCAG
AGCTTTTACAGCAGAGGAACTCTAAGGGGGAGTTGCCCTTGGATTATGTGCTGTCCCCTAAAGA
CAAGGAAGAACTATTTGCCATTACAAATATAGACGATACAGTGGACAACTTTCATGCTAAGACA
CAGAAACATTTTTATCACGAACAACTGGAATTTGGTTCATTTTTACTTAGTAGGATGTTGATTA
GTTTTTGTTCAATATTTGATTTATCCTCAGAATTCATCCTAGCTTTCAAAGGGTTAAGTCATCT
AAATGAGTTGCTTATGGCATGCAATACTGATACAGAACCCACCAGTGCACATTCTGACTGGCTA
CTAGATCTTTATACTAGGAATATAAAGACATTAAAGAAGCTCCCAAGTGTTCTTAAGGAACTGC
CTGAGAATCTAAATGTATGTCCTGGAGTTCATACTGAGGCCTTATTGGTGACCCTGGAAATGAT
GTGTCAGTCAATCACAGAGGTGTCATAATGCCAGAAAGTATGAGTCAGATTTCTAAACATGCAA
CATGCTTTGTCACCTAATATATCCATAGCGTATGGAAAAATAATTAATTTCAGTTATTCACTGA
TAGCAAATTTTCATAGCACTTAAAAAACATCTACAGATCTAAAATGCAGGCTCAGGATTTAACT
CAAAAAGAAACAATAATAAAATGAAGTAGTTTTGTTAGATATAAAATGCTTTCACTAATTTTTA
AAAAAAAAACCTTCAAATATTTATTTATATTGTATATGTAGAAAATAATTTAAATATTTTTTCA
AATAAAAATGCCCTTTCCTTTGAGTGCTATAGATCTTAAAATCATGGCAAGGATATTCATGGAA
ATGTGTATCTATATACTTGTAAAAGTTGTTTCTTCTTTTTAGGCTAGTGTTTAAGATGCATTTG
CTTTTATGTGTTTTTAAATAAACCTTTCTAGAACTTTA

hide sequence

RefSeq Acc Id:

XM_063281458 ⟹ XP_063137528

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	8,498,776 - 8,596,860 (-)	NCBI

RefSeq Acc Id:

XM_063281459 ⟹ XP_063137529

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	8,514,337 - 8,606,251 (-)	NCBI

RefSeq Acc Id:

XR_010063587

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	8,520,227 - 8,606,251 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099870	(Get FASTA)	NCBI Sequence Viewer
	XP_063137528	(Get FASTA)	NCBI Sequence Viewer
	XP_063137529	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM09927	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001099870 ⟸ NM_001106400

- UniProtKB:

A6I4G9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEGGATKHVIQMTGFKMEEKEALVKLLLKLDCTFIKSEKYKNCTHLIAERLCKSEKFLAACAAG
KWVLTKDYIIHSAKSGRWLDETTYEWGYKIEKDSHYSPQMQSAPKRWREELKRTGAPGAFHRWK
VVLLVRADKRSDSLVRVLEAGKANVILPRSSPSGITHVIASNARISAEREQENFKAPFYPIQYL
GDFLLEKEIQNDEDSQISSGRTKYNSQEKSKDFKRDMGFLEMKGAGENMYRTQNKMGNHNENVN
DKFVLSEHHKKKFRDFRKDMKSIKKTNTFRRRAHENQKETKKKDKNVQRSYILRKKNIKEGYCK
TDDAHDTTRSTLKKRWSYRDQKEMKNSLLTDCAKESETKDVKANVDLTEVKNALKRQIHRDIYR
AQAVRYNCIRVDKQPVYNVEVKNAEFPRGILNLIESLIEGQFFKEAIEELSSLQAHYVPPVCLL
HALLENVLQDNIDTFSGRYFHILSALLHLHPPWKSPAMSRYYLELFQCPTCMKGAWPLVEMLVR
SCLFNEGFCHQISENIGSKVAHLTLLKFFFNLLESEVRHLSQKLCDWSDSQNLKVAEKAILHEI
FWSGSETSGLLTKPVNMLLEWTIYSHKEKCKSNDVFKHELSYLLTGILGTAVDYWIFLGIQMGR
NVIRHMSEDLGSYISLSCDDFSSKELELFICSFSSSWLQMFVAEAIFKKLCLQGPTSTCTEPLS
LQKIIDSYLPVLGKMDIHGAGKMQMPKKLCQRPCLESQRALLMLNGAKQKQADGRPEFLELNHA
KCSSSLKKLKKKSEGESSCSKENCPSLVTKMNFHKTNLKGETALHRVCIKNQVEKLIILLSLPG
IDINVKDNAGWTPLHEACNYGNTVCVREILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLL
QHGGPELLQQRNSKGELPLDYVLSPKDKEELFAITNIDDTVDNFHAKTQKHFYHEQLEFGSFLL
SRMLISFCSIFDLSSEFILAFKGLSHLNELLMACNTDTEPTSAHSDWLLDLYTRNIKTLKKLPS
VLKELPENLNVCPGVHTEALLVTLEMMCQSITEVS

hide sequence

Ensembl Acc Id:

ENSRNOP00000018457 ⟸ ENSRNOT00000018457

RefSeq Acc Id:	XP_063137528 ⟸ XM_063281458
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063137529 ⟸ XM_063281459
- Peptide Label:	isoform X2

Protein Domains

BRCT

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZVR6-F1-model_v2	AlphaFold	D3ZVR6	1-1059	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691039

Promoter ID:

EPDNEW_R1564

Type:

multiple initiation site

Name:

Slf1_1

Description:

SMC5-SMC6 complex localization factor 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	4,195,812 - 4,195,872	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304857	AgrOrtholog
BioCyc Gene	G2FUF-55071	BioCyc
Ensembl Genes	ENSRNOG00000040279	Ensembl
Gene3D-CATH	Ankyrin repeat-containing domain	UniProtKB/TrEMBL
	BRCT domain	UniProtKB/TrEMBL
InterPro	Ankyrin_rpt	UniProtKB/TrEMBL
	Ankyrin_rpt-contain_sf	UniProtKB/TrEMBL
	BRCT_dom	UniProtKB/TrEMBL
	BRCT_dom_sf	UniProtKB/TrEMBL
	BRCT_SLF1	UniProtKB/TrEMBL
	Slf1	UniProtKB/TrEMBL
KEGG Report	rno:294601	UniProtKB/TrEMBL
NCBI Gene	294601	ENTREZGENE
PANTHER	SMC5-SMC6 COMPLEX LOCALIZATION FACTOR PROTEIN 1	UniProtKB/TrEMBL
	SMC5-SMC6 COMPLEX LOCALIZATION FACTOR PROTEIN 1	UniProtKB/TrEMBL
Pfam	Ank_2	UniProtKB/TrEMBL
	RTT107_BRCT_5	UniProtKB/TrEMBL
PhenoGen	Slf1	PhenoGen
PROSITE	ANK_REP_REGION	UniProtKB/TrEMBL
	ANK_REPEAT	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000040279	RatGTEx
SMART	ANK	UniProtKB/TrEMBL
	BRCT	UniProtKB/TrEMBL
Superfamily-SCOP	Ankyrin repeat	UniProtKB/TrEMBL
	BRCT domain	UniProtKB/TrEMBL
UniProt	A6I4G9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-07-15	Slf1	SMC5-SMC6 complex localization factor 1	Ankrd32	ankyrin repeat domain 32	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Ankrd32	ankyrin repeat domain 32	Ankrd32_predicted	ankyrin repeat domain 32 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Ankrd32_predicted	ankyrin repeat domain 32 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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