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Gene: Acp1 (acid phosphatase 1) Ictidomys tridecemlineatus

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Symbol:

Acp1

Name:

acid phosphatase 1

RGD ID:

12519993

Description:

ENCODES a protein that exhibits acid phosphatase activity (ortholog); protein tyrosine phosphatase activity (ortholog); SH3 domain binding (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; riboflavin metabolic pathway; ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); conduct disorder (ortholog); coronary artery disease (ortholog); FOUND IN cytoplasm (inferred); cytoplasmic side of plasma membrane (inferred); cytosol (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

acid phosphatase 1, soluble; low molecular weight phosphotyrosine protein phosphatase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ACP1 (acid phosphatase 1)	NCBI	Ortholog
Mus musculus (house mouse):	Acp1 (acid phosphatase 1, soluble)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Acp1 (acid phosphatase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Acp1 (acid phosphatase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ACP1 (acid phosphatase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ACP1 (acid phosphatase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ACP1 (acid phosphatase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ACP1 (acid phosphatase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Acp1 (acid phosphatase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Acp1 (acid phosphatase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	45,375,753 - 45,390,385 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936532	132,350 - 145,285 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936532	130,799 - 145,285 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

attention deficit hyperactivity disorder (ISO)

conduct disorder (ISO)

coronary artery disease (ISO)

diabetes mellitus (ISO)

diabetic retinopathy (ISO)

Hypertriglyceridemia (ISO)

Insulin Resistance (ISO)

obesity (ISO)

type 1 diabetes mellitus (ISO)

type 2 diabetes mellitus (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chemical synaptic transmission (ISO)

Cellular Component

cytoplasm (IEA)

cytoplasmic side of plasma membrane (IEA)

cytosol (IEA)

sarcolemma (IEA)

Molecular Function

acid phosphatase activity (IEA,ISO)

hydrolase activity (IEA)

non-membrane spanning protein tyrosine phosphatase activity (IEA)

phosphatase activity (IEA)

phosphoprotein phosphatase activity (IEA)

protein binding (ISO)

protein tyrosine phosphatase activity (IEA,ISO)

SH3 domain binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

ephrin - ephrin receptor bidirectional signaling axis (ISO)

riboflavin metabolic pathway (ISO)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Acp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	45,375,753 - 45,390,385 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936532	132,350 - 145,285 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936532	130,799 - 145,285 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ACP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	264,947 - 278,283 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	264,140 - 279,100 (+)	Ensembl			hg38	GRCh38
GRCh37	2	264,947 - 278,283 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	254,872 - 268,283 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	254,895 - 268,280	NCBI
Celera	2	327,509 - 340,926 (+)	NCBI		Celera
Cytogenetic Map	2	p25.3	NCBI
HuRef	2	261,431 - 274,847 (+)	NCBI		HuRef
CHM1_1	2	264,806 - 278,220 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	265,202 - 278,542 (+)	NCBI		T2T-CHM13v2.0

Acp1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	30,943,325 - 30,961,616 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	30,943,325 - 30,961,588 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	12	30,893,326 - 30,911,619 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	30,893,326 - 30,911,589 (-)	Ensembl			mm10	GRCm38
MGSCv37	12	31,578,191 - 31,596,477 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	12	31,479,378 - 31,497,608 (-)	NCBI		MGSCv36	mm8
Celera	12	32,346,148 - 32,364,519 (-)	NCBI		Celera
Cytogenetic Map	12	A2	NCBI
cM Map	12	13.0	NCBI

Acp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	53,233,937 - 53,249,576 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	53,233,948 - 53,251,959 (-)	Ensembl				GRCr8
mRatBN7.2	6	47,506,380 - 47,522,021 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	47,506,380 - 47,522,021 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	47,812,337 - 47,827,906 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	48,127,247 - 48,142,816 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	47,572,321 - 47,587,872 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	6	54,675,339 - 54,690,909 (-)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	6	54,092,215 - 54,107,743 (-)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	6	51,887,503 - 51,903,031 (-)	NCBI		Lyon_Hypertensive
F344_StmMcwi	6	51,114,670 - 51,130,239 (-)	NCBI		F344_StmMcwi
Rnor_6.0	6	49,836,064 - 49,851,714 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	49,836,075 - 49,851,714 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	58,515,986 - 58,531,100 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	48,784,243 - 48,798,868 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	46,711,467 - 46,727,154 (-)	NCBI		Celera
RGSC_v3.1	6	48,785,927 - 48,801,957 (-)	NCBI
Cytogenetic Map	6	q16	NCBI

Acp1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955487	290,557 - 302,547 (+)	Ensembl
ChiLan1.0	NW_004955487	290,434 - 302,405 (+)	NCBI	ChiLan1.0	ChiLan1.0

ACP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	126,269,693 - 126,283,122 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	126,273,669 - 126,287,098 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	257,892 - 271,320 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	253,645 - 267,086 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	253,656 - 267,086 (+)	Ensembl			panPan2	panpan1.1

ACP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	243,757 - 251,151 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	243,713 - 250,758 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	230,458 - 243,370 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	298,408 - 311,318 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	298,504 - 312,878 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	225,421 - 238,323 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	243,384 - 256,562 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	248,297 - 261,206 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

ACP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	132,667,045 - 132,684,674 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	132,671,408 - 132,684,793 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	142,383,352 - 142,396,021 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ACP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	107,449,327 - 107,465,478 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666045	4,476,886 - 4,492,471 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Acp1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624846	1,736,038 - 1,747,009 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624846	1,735,944 - 1,748,495 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Acp1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	7	44,294,451 - 44,309,889 (-)	NCBI		Rrattus_CSIRO_v1

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021727734	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_078029772	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_078029773	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010001352	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JBPVTT010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000002511 ⟹ ENSSTOP00000002245

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936532	137,303 - 144,512 (+)	Ensembl

Ensembl Acc Id:

ENSSTOT00000040049 ⟹ ENSSTOP00000032145

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936532	132,350 - 145,285 (+)	Ensembl

RefSeq Acc Id:

XM_021727734 ⟹ XP_021583409

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024406292	45,375,753 - 45,390,385 (+)	NCBI
SpeTri2.0	NW_004936532	130,799 - 145,285 (+)	NCBI

Sequence:

show sequence

ATGGCGCGCCTGTTCCTGGTCCCAGGGCCAGGTAACATTTGCCGGTCACCTATCGCAGAAGCAG
TTTTCAGAAAACTTGTAACTGATCAAAACGATTTAGACAACTGGAGGATAGACAGTGCAGCCAC
ATCTACCTATGAAGTGGGGAACCCCCCTGACTACCGTGGGCAGAGTTGCATGAGGAAGCATGGC
ATCCCCATGAACCACGTTGCCCGGCAGGTGACCAAAGAAGATTTGGCCACATTCGACTATATAT
TGTGTATGGATGAAAGCAACCTGAGAGATTTGAATAGAAAAAGTAATCAAGTTAAAAACTGCAA
AGCTAAAATTGAACTGCTTGGAAGCTATGATCCACAGAAACAACTCATTATTGAAGATCCCTAT
TATGGGAACGATGCTGACTTTGAAGTGGTGTACCAGCAGTGTCTCAGGTGCTGCAAAGCCTTCC
TGGAGAAGGCCCACTAGGACCACCTGCCCACTACCAGCTGGGGACGCTCCCTATCCACGTTCTG
CATCCTCATCCTGTGCTCCGGTGTACTGCCACTCCTTTGACCCAGGCCCTGCCTGCCCCTTCAG
CTGACTGTTGTCTCTGACCTGACCTGACAGATCATCGTAGTGGAAACCAGCTGTGTCTACAGAA
GAATCAATAAAAATGTTGGACTCAAAGACAGTTTGTAGGGTGCAGTGAGAGTTCTTAGACTAGT
GGAGCCTTCTCTTTGCCCTGATTATGCTAGTGGAGTGAGCAGAGAGAAAAACAGCCCCAACCAC
TAAGTACGCACACCCGAAGGCCCAGGTTAGTCTCTGTGCCCAGTAAGGTTGGATGGCCTGGTCT
CCCTGCAGTGATTGTGTGTGGCTGGCCAGTGCCTACAGGGCACCTGTGCTCATCTGTGTATCCA
GAGTCACAGTGACCCTGTCCATAGCGGCTCTCCATGGCTGCAGCAAGTGTTTTAGCTCACCCAC
ACACAGTGCACATGATAGGAGACAGACCGATGGGATTGATCTTTAGCACCTTTAGTATTTGTTG
GTTTTTGTCTGATTTAAGTCAGCTTATTTGCTCTCATTTGAGCCACTTTGTATCCAAAAATTTA
ATTATATCTGGAAAGGACACTTGTATGCTATGTATCCTATGGTTGGTTGAGGGGTATGTTTGTT
TTATATGCACAGGTAACTCAAATGTAAATTGGCTTAGGTATGAAAAAATAATTTAAGCAGTCAG
TTATGTTGGTGTCCTTAAGTAT

hide sequence

Protein Sequences


Protein RefSeqs	XP_077885898	(Get FASTA)	NCBI Sequence Viewer
	XP_077885899	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000002245.3
	ENSSTOP00000032145.1
GenBank Protein	KAG3267482	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_021583409 ⟸ XM_021727734
- Sequence:	show sequence MARLFLVPGPGNICRSPIAEAVFRKLVTDQNDLDNWRIDSAATSTYEVGNPPDYRGQSCMRKHG IPMNHVARQVTKEDLATFDYILCMDESNLRDLNRKSNQVKNCKAKIELLGSYDPQKQLIIEDPY YGNDADFEVVYQQCLRCCKAFLEKAH hide sequence

Ensembl Acc Id:

ENSSTOP00000002245 ⟸ ENSSTOT00000002511

Ensembl Acc Id:

ENSSTOP00000032145 ⟸ ENSSTOT00000040049

Protein Domains

Phosphotyrosine protein phosphatase I

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000002520	Ensembl, UniProtKB/TrEMBL
	ENSSTOG00015006872	ENTREZGENE
Ensembl Transcript	ENSSTOT00000002511.3	UniProtKB/TrEMBL
	ENSSTOT00000040049.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.2300	UniProtKB/TrEMBL
InterPro	LMW_PTPase	UniProtKB/TrEMBL
	Ptyr_pPase	UniProtKB/TrEMBL
	Ptyr_pPase_sf	UniProtKB/TrEMBL
	Tyr_Pase_low_mol_wt_mml	UniProtKB/TrEMBL
	Tyr_phospatase_low_mol_wt	UniProtKB/TrEMBL
NCBI Gene	Acp1	ENTREZGENE
PANTHER	LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE	UniProtKB/TrEMBL
	LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE	UniProtKB/TrEMBL
	LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE	UniProtKB/TrEMBL
Pfam	LMWPc	UniProtKB/TrEMBL
PRINTS	LMWPTPASE	UniProtKB/TrEMBL
	MAMMALPTPASE	UniProtKB/TrEMBL
SMART	LMWPc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52788	UniProtKB/TrEMBL
UniProt	A0A287DF34_ICTTR	UniProtKB/TrEMBL
	I3M0K1_ICTTR	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-09-26	Acp1	acid phosphatase 1		acid phosphatase 1, soluble	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Annotations - SMPDB

Imported Annotations - PID (archival)

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Imported Annotations - SMPDB

Imported Annotations - PID (archival)