SAP18 (Sin3A associated protein 18) - Rat Genome Database

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Gene: SAP18 (Sin3A associated protein 18) Canis lupus familiaris
Analyze
Symbol: SAP18
Name: Sin3A associated protein 18
RGD ID: 12363054
Description: ENCODES a protein that exhibits transcription corepressor activity (inferred); INVOLVED IN negative regulation of mRNA splicing, via spliceosome (ortholog); positive regulation of apoptotic process (ortholog); regulation of alternative mRNA splicing, via spliceosome (ortholog); PARTICIPATES IN Hedgehog signaling pathway; FOUND IN ASAP complex (ortholog); cytosol (ortholog); exon-exon junction complex (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: histone deacetylase complex subunit SAP18
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: LOC475060  
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12517,006,025 - 17,014,948 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2517,008,110 - 17,014,544 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2517,104,759 - 17,111,055 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02517,144,308 - 17,151,179 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2517,142,400 - 17,150,735 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12517,019,023 - 17,025,322 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02517,030,495 - 17,036,791 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02517,086,581 - 17,092,879 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16723480   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SAP18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12517,006,025 - 17,014,948 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2517,008,110 - 17,014,544 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2517,104,759 - 17,111,055 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02517,144,308 - 17,151,179 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2517,142,400 - 17,150,735 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12517,019,023 - 17,025,322 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02517,030,495 - 17,036,791 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02517,086,581 - 17,092,879 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
SAP18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381321,140,119 - 21,149,097 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1321,140,119 - 21,149,097 (+)Ensemblhg38GRCh38
GRCh371321,714,258 - 21,723,236 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361320,612,685 - 20,620,977 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341320,612,684 - 20,620,974NCBI
Celera132,776,645 - 2,785,216 (+)NCBICelera
Cytogenetic Map13q12.11NCBI
HuRef132,516,765 - 2,524,676 (+)NCBIHuRef
CHM1_11321,682,666 - 21,691,235 (+)NCBICHM1_1
T2T-CHM13v2.01320,331,500 - 20,342,169 (+)NCBIT2T-CHM13v2.0
Sap18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391458,035,646 - 58,042,437 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1458,035,637 - 58,044,095 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381457,798,189 - 57,804,980 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1457,798,180 - 57,806,638 (+)Ensemblmm10GRCm38
MGSCv371458,417,026 - 58,423,817 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361456,752,364 - 56,759,087 (+)NCBIMGSCv36mm8
Celera1455,594,725 - 55,601,516 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1430.51NCBI
Sap18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81536,058,784 - 36,063,089 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1087,156,914 - 87,158,257 (+)EnsemblGRCr8
GRCr8 Ensembl1536,058,776 - 36,067,462 (+)EnsemblGRCr8
mRatBN7.21531,943,228 - 31,947,534 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,657,353 - 86,657,975 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl1531,943,230 - 31,950,038 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1533,934,558 - 33,938,863 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01535,085,228 - 35,089,533 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01533,343,312 - 33,347,617 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01538,069,320 - 38,073,625 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1538,069,320 - 38,073,622 (+)Ensemblrn6Rnor6.0
Rnor_5.01541,910,111 - 41,914,416 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41536,839,247 - 36,843,552 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1531,653,889 - 31,658,194 (+)NCBICelera
RGSC_v3.11536,854,946 - 36,859,259 (+)NCBI
Cytogenetic Map15p12NCBI
Sap18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554971,867,771 - 1,869,974 (+)Ensembl
ChiLan1.0NW_0049554971,862,026 - 1,869,974 (+)NCBIChiLan1.0ChiLan1.0
SAP18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21420,769,402 - 20,778,614 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11311,882,485 - 11,891,676 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0132,468,402 - 2,475,504 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11320,776,818 - 20,785,533 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1320,776,818 - 20,785,533 (+)EnsemblpanPan2panpan1.1
Sap18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945119,062,918 - 119,068,973 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936720610,478 - 616,546 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936720610,478 - 616,529 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SAP18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl111,291,202 - 1,298,983 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1111,290,195 - 1,298,990 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.211427,644 - 433,170 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SAP18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1363,736 - 72,521 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl361,957 - 72,524 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605744,543,593 - 44,553,130 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sap18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477616,451,980 - 16,457,276 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477616,451,980 - 16,457,323 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Sap18
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11267,027,757 - 67,032,199 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in SAP18
81 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000044246   ⟹   ENSCAFP00000037751
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2517,008,110 - 17,014,544 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845037481   ⟹   ENSCAFP00845029366
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2517,142,400 - 17,150,735 (-)Ensembl
RefSeq Acc Id: NM_001252161   ⟹   NP_001239090
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12517,008,110 - 17,014,405 (-)NCBI
Dog10K_Boxer_Tasha2517,104,759 - 17,111,055 (-)NCBI
ROS_Cfam_1.02517,144,494 - 17,150,790 (-)NCBI
UMICH_Zoey_3.12517,019,023 - 17,025,322 (-)NCBI
UNSW_CanFamBas_1.02517,030,495 - 17,036,791 (-)NCBI
UU_Cfam_GSD_1.02517,086,581 - 17,092,879 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038434581   ⟹   XP_038290509
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02517,144,308 - 17,151,179 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001239090 (Get FASTA)   NCBI Sequence Viewer  
  XP_038290509 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000067955.1
  ENSCAFP00030038532.1
  ENSCAFP00040039012.1
  ENSCAFP00845029366
  ENSCAFP00845029366.1
RefSeq Acc Id: NP_001239090   ⟸   NM_001252161
- UniProtKB: A0A8C0RSG0 (UniProtKB/TrEMBL),   A0A8C0LN28 (UniProtKB/TrEMBL),   A0A8C0JN23 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000037751   ⟸   ENSCAFT00000044246
RefSeq Acc Id: XP_038290509   ⟸   XM_038434581
- Peptide Label: isoform X1
Ensembl Acc Id: ENSCAFP00845029366   ⟸   ENSCAFT00845037481

Promoters
RGD ID:13687737
Promoter ID:EPDNEW_C5807
Type:initiation region
Name:SAP18_1
Description:Sin3A associated protein 18
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12517,014,330 - 17,014,390EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000032070 Ensembl
  ENSCAFG00000054742 UniProtKB/TrEMBL
  ENSCAFG00030024017 UniProtKB/TrEMBL
  ENSCAFG00040023970 UniProtKB/TrEMBL
  ENSCAFG00845021235 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000109966.1 UniProtKB/TrEMBL
  ENSCAFT00030044154.1 UniProtKB/TrEMBL
  ENSCAFT00040044662.1 UniProtKB/TrEMBL
  ENSCAFT00845037481 ENTREZGENE
  ENSCAFT00845037481.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.20.550 UniProtKB/TrEMBL
InterPro Hist_deAcase_cplx_SAP18 UniProtKB/TrEMBL
  SAP18 UniProtKB/TrEMBL
  SAP18_sf UniProtKB/TrEMBL
KEGG Report cfa:609404 UniProtKB/TrEMBL
NCBI Gene SAP18 ENTREZGENE
PANTHER HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18 UniProtKB/TrEMBL
  PTHR13082 UniProtKB/TrEMBL
Pfam SAP18 UniProtKB/TrEMBL
PIRSF HDAC_SAP18 UniProtKB/TrEMBL
UniProt A0A8C0JN23 ENTREZGENE
  A0A8C0LN28 ENTREZGENE
  A0A8C0RSG0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PAM9_CANLF UniProtKB/TrEMBL
  A0A8P0TJR9_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:45859 ENTREZGENE