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Gene: MCOLN2 (mucolipin TRP cation channel 2) Canis lupus familiaris

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Symbol:

MCOLN2

Name:

mucolipin TRP cation channel 2

RGD ID:

12118432

Description:

ENCODES a protein that exhibits monoatomic anion channel activity (ortholog); potassium channel activity (ortholog); sodium channel activity (ortholog); INVOLVED IN inner ear auditory receptor cell differentiation (ortholog); locomotory behavior (ortholog); macrophage migration (ortholog); FOUND IN cytoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

mucolipin 2; mucolipin-2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	62,956,797 - 63,008,527 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	62,956,804 - 63,200,612 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	65,604,897 - 65,656,536 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	63,494,889 - 63,546,421 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	63,494,883 - 63,546,415 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	63,021,712 - 63,076,135 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	62,992,176 - 63,043,489 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	63,500,378 - 63,551,982 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium-mediated signaling (IEA)

inner ear auditory receptor cell differentiation (ISO)

iron ion transmembrane transport (IEA)

locomotory behavior (ISO)

macrophage migration (ISO)

monoatomic cation transmembrane transport (IEA)

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA)

neutrophil migration (ISO)

positive regulation of chemokine (C-C motif) ligand 5 production (ISO)

positive regulation of chemokine (C-X-C motif) ligand 2 production (ISO)

positive regulation of chemokine production (ISO)

positive regulation of macrophage inflammatory protein 1 alpha production (ISO)

positive regulation of monocyte chemotactic protein-1 production (ISO)

regulation of chemokine (C-X-C motif) ligand 2 production (ISO)

Cellular Component

cytoplasm (ISO)

endosome membrane (IEA)

lysosomal membrane (IBA)

membrane (IBA)

plasma membrane (IBA,IEA)

recycling endosome (IEA)

Molecular Function

identical protein binding (IEA)

iron ion transmembrane transporter activity (IEA)

monoatomic anion channel activity (ISO)

monoatomic cation channel activity (IEA)

monoatomic cation transmembrane transporter activity (IEA)

NAADP-sensitive calcium-release channel activity (IBA)

potassium channel activity (ISO)

protein binding (ISO)

sodium channel activity (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

MCOLN2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	62,956,797 - 63,008,527 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	62,956,804 - 63,200,612 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	65,604,897 - 65,656,536 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	63,494,889 - 63,546,421 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	63,494,883 - 63,546,415 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	63,021,712 - 63,076,135 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	62,992,176 - 63,043,489 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	63,500,378 - 63,551,982 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

MCOLN2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	84,925,583 - 84,997,113 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	84,925,583 - 84,997,115 (-)	Ensembl			hg38	GRCh38
GRCh37	1	85,391,266 - 85,462,796 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	85,163,854 - 85,235,384 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	85,103,287 - 85,174,817	NCBI
Celera	1	83,635,160 - 83,706,701 (-)	NCBI		Celera
Cytogenetic Map	1	p22.3	NCBI
HuRef	1	83,501,272 - 83,572,477 (-)	NCBI		HuRef
CHM1_1	1	85,506,121 - 85,577,633 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	84,766,210 - 84,837,786 (-)	NCBI		T2T-CHM13v2.0

Mcoln2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	145,855,552 - 145,901,269 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	145,855,588 - 145,901,268 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	3	146,149,796 - 146,195,514 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	146,149,833 - 146,195,513 (+)	Ensembl			mm10	GRCm38
MGSCv37	3	145,812,797 - 145,858,476 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	3	146,087,229 - 146,132,898 (+)	NCBI		MGSCv36	mm8
Celera	3	152,597,587 - 152,645,127 (+)	NCBI		Celera
Cytogenetic Map	3	H2	NCBI
cM Map	3	71.03	NCBI

Mcoln2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	237,714,100 - 237,762,979 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	237,714,084 - 237,762,978 (+)	Ensembl				GRCr8
mRatBN7.2	2	235,053,816 - 235,102,703 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	235,053,816 - 235,102,702 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	242,843,483 - 242,892,393 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	240,734,735 - 240,783,786 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	235,601,104 - 235,650,008 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	2	237,610,880 - 237,659,920 (+)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	2	237,733,440 - 237,783,324 (+)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	2	237,420,362 - 237,470,251 (+)	NCBI		Lyon_Hypertensive
F344_StmMcwi	2	237,482,925 - 237,532,718 (+)	NCBI		F344_StmMcwi
Rnor_6.0	2	252,018,594 - 252,068,209 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	252,018,597 - 252,068,271 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	270,540,814 - 270,589,451 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	244,323,411 - 244,385,583 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	227,034,241 - 227,082,591 (+)	NCBI		Celera
RGSC_v3.1	2	244,326,614 - 244,371,707 (+)	NCBI
Cytogenetic Map	2	q44	NCBI

Mcoln2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	8,978,226 - 9,037,174 (+)	Ensembl
ChiLan1.0	NW_004955423	8,977,210 - 9,037,110 (+)	NCBI	ChiLan1.0	ChiLan1.0

MCOLN2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	141,938,347 - 142,018,835 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	141,093,585 - 141,171,845 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	117,473,542 - 117,552,814 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	86,333,534 - 86,409,043 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	86,333,534 - 86,409,043 (-)	Ensembl			panPan2	panpan1.1

Mcoln2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	95,561,224 - 95,614,704 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936608	690,253 - 744,001 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936608	690,253 - 744,803 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MCOLN2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	128,776,430 - 128,836,951 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	128,772,904 - 128,836,958 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	119,212,679 - 119,272,344 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MCOLN2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	48,355,014 - 48,435,888 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	48,376,004 - 48,426,171 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666033	69,343,923 - 69,413,062 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mcoln2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624742	12,527,608 - 12,591,518 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624742	12,527,562 - 12,591,797 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Mcoln2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	14,705,809 - 14,752,963 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in MCOLN2
694 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005621992	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005621993	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038480190	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038480191	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038480192	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038480193	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038541520	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038541521	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038541522	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038541523	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038556350	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038556352	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038605660	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038605661	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038605662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038605663	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038670264	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038670265	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038670266	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038670267	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000078	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000090	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000065	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000032327 ⟹ ENSCAFP00000030104

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	6	62,956,804 - 63,008,033 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00000064729 ⟹ ENSCAFP00000053883

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	6	62,956,804 - 63,200,612 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845002367 ⟹ ENSCAFP00845001882

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	6	63,494,883 - 63,544,636 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845002397 ⟹ ENSCAFP00845001905

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	6	63,494,898 - 63,546,415 (+)	Ensembl

RefSeq Acc Id:

XM_005621992 ⟹ XP_005622049

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	6	62,956,797 - 63,008,527 (+)	NCBI
Dog10K_Boxer_Tasha	6	65,604,897 - 65,656,536 (+)	NCBI

Sequence:

show sequence

CCGAGGCCGCTTCTCCGCAGCCAGACCTCGCGGCAGACACCCGGCGCCCCAGCTCCCGGCGCCC
CCCAGAGCCGAGCGCAGGGGCCTGGGGCCGGCACGTCGGGGCCGAGGCGGGTGCAGCCGTCCAC
CCTCCGCGCCCCTCCTGGCGCTCGGGGCCCGCGGCATGCGCCCCGGCCTGGAGGCCCTGCACCT
GCCGGCGTGGAGCGGAGCCTCCGGCCCGTCCTGGGGGCCCCGCGGCAGAAATGCAATGGCTCAT
CTTGATTCTGACGTGAAAGAAGAATGTCTGAGGGAAGACCTGAAGTTTTACTTCATGAACCCTT
GTGAAAAATACCGAGCCAGACACCAGATTCCATGGAAGCTGGGATTGCAGATTTTGAAGATAGT
CATGGTTACCACACAGCTTGTTCGTTTTGGTTTAAGTAACCAGATGGTAGTTGCTTTCAAAGAA
GAGAACACTGTTGCTTTTAAGCACTTGTTTTTAAAAGGATACTCTGGCACGGATGAAGATGACT
ATAGTTGCAGTGTCTATACTCAAGAGGATGCCTATGAGAGCATCTTTTTTGCTATCAATCAGTA
TCATCATCTAAAGAACATATCCCTGGGGACACTCAGTTACGGAGAAAATGAAGACAATAGAACT
GGCTTGAAAGTCTGTAAGCAGCATTATAAGAAAGGGGCCATGTTTCCTTCTAATGACACGCTGA
ACATTGACAGCGACATTGAAGTAGATTGTGTTCACTTAGACCTCTCCAAGGACCCTCAGGACTG
GAAGAACTTGTCATTCTTCAGACTGGAATTTTACCGGCTCTTAGAAGTTGAAATTTCCTTTCGC
CTCAAAGGCATCGACCTACAGACAATTCATTCCCGAGAGTTACCAGACTGTTACGTCTTTCAGA
ATACGATTACCTTTGACAATAAAGCTCACAGTGGCAAGATCAAAATTTATTTTGACAGTGATGC
TAAAATTGAAGAATGTAAAGACTTGAACATATCTGGATCTATTCAGAAAAATACTCAGTATGTC
CTGGTGTTTGATGCATTTGTCATTGTGATTTGCTTGGCATCTCTTATTCTGTGCACAAGATCCA
TTGTTCTAGCTCTCAGGTTACGCAAGAGATTTCTAAATTTCTTCCTGGAGAAGTATAAGCGACG
TGTGTGTAACACCGACCAGTGGGAGTTCATCAATGGATGGTATGTCCTGGTGATTATCAGCGAC
CTAATGACCATAATTGGATCCATATTAAAAATGGAAATTAAAGCAAAGAATCTCACAAATTACG
ATCTGTGCAGCATTTTGCTCGGAACGTCTACGCTCTTTGTCTGGGTTGGCGTCATCAGATACCT
GGGGTACTTCCAAGCATATAATGTGCTCATTTTAACGATGCAAGCCTCACTGCCCAAGGTTCTG
CGCTTCTGCGCCTGTGCTGGTATGATCTATCTGGGCTACACGTTCTGTGGCTGGATTGTCTTAG
GACCATATCATGACAAGTTTGAAGATCTGAACACAGTTGCTGAATGTCTGTTCTCTCTGGTCAA
TGGCGACGACATGTTTGCGACCTTTGCTGAAATCCAGCAGAAGAGCGTCCTGGTGTGGCTGTTC
AGTCGCCTGTACTTATACTCCTTCATCAGTCTTTTTATATATATGATCCTCAGTCTGTTCATTG
CACTTATTACAGACTCTTATGACACCATTAAGAAATACCAACAGAATGGGTTTCCTGAAACGGA
TCTTCAGGAATTCCTGAAGGAATGTAGTAGCAAAGAGAAGTATCAGAAAGAGTCCTCAGGCTTC
TTGTCCTGTGTCTGCTGCCTAAGGAGGAAAGGAAGTGATGACCACTTGACACTTGTCAACTAAA
ATCCTTCTGCTAAAGATAATCGGGCGTCAGGCCTCTTTACCCAGTGACAATGCAGAGGGACCCC
AAACAACTTGGACCAGCAGTTCCAAAACTCCCAACTTATTTATTTGTGGAGAGGGAAAGAGGAC
TGTCACCTGGTTGAACACAACTGAAGTTCCAAAGTTCCTCTTATAAACTTGGATGATGAAGAAT
AGACCAGAGTCAACTACTGAGCATTGGTGCAATAGAGCAGTGACAATGAAATTCTGCATTGGAC
TTTAATTTATGACATCACAATGCTGGGATGGAAAAAAATGTCACATTTCAGAGTGTGCAAAAAC
AATGGCACCTAAAGTCATGCGTTGAAAGTTGTGTGTTTATCATCCAATAAGGATTTGTTTTAAA
AGTGGTTCTTGGACTAGAAGACATTTGTAAATTCATGGTATGCACAGAAATGAACTTGGTTGCA
ATAATAAATTAAAAATTCCAAGCTGGAGAACTATTAAGCCTTTTAAAGAATACACTTAAACCAA
CAAAAAGACCTCTTGTAGTGGACATTTCTGGGCCTGTGTGTGTGTTTGTTTGTTTCAGCATGAC
AGGAAGCAGCTGTTGGCATGTTCAGTGAGATAAATTGGAAGCAGAATCATTTGGACATGTTGTC
ATTTGTGCTAATTGTTGATTGTGCACACATGACATGTGGAAATGAACTGTAGCAGTGGTCACTC
CTTTTAACAGTTGAACTCCACTATGGTGGTGATTTACCCTTGTCAAGCAAGGAAAAATGGTATT
TTTTTCCTAAATAAATTTATTTTTTATCACAAAAAAAGGAGTTACTGCTATTTTTTTAGTATAA
TATTTCTTAATATTAACTTAGCGCGAAATTCAGATCACATCTCTTTTGACTATCTGGTCTCCAA
AAGGGGTATCTCACTTTCTTAAAGGCAGTGAAGGAGGGCTAATATGTAGAAGGTATTCAATAAA
TATTTATGATAATGTCTTAA

hide sequence

RefSeq Acc Id:

XM_005621993 ⟹ XP_005622050

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	6	62,961,917 - 63,008,527 (+)	NCBI
Dog10K_Boxer_Tasha	6	65,610,051 - 65,656,535 (+)	NCBI

Sequence:

show sequence

GAGATTTGCTGGAGTGGCAAATGTGAAAGTCCACATCATGTGGGTAGTATTTAAAGCCACAGGA
CTGGGCAAAGTCTTCTAGAAGGGAGGACTGAGGATGGAAGATCCCTCGGCTGTGTCCTGAGACA
CTCTGGCACCTGAAATTGGATGGAAGAGGAGCCAGCAAAGGAGACTGGGAAATGCCCAGTGAGA
AATGCAATGGCTCATCTTGATTCTGACGTGAAAGAAGAATGTCTGAGGGAAGACCTGAAGTTTT
ACTTCATGAACCCTTGTGAAAAATACCGAGCCAGACACCAGATTCCATGGAAGCTGGGATTGCA
GATTTTGAAGATAGTCATGGTTACCACACAGCTTGTTCGTTTTGGTTTAAGTAACCAGATGGTA
GTTGCTTTCAAAGAAGAGAACACTGTTGCTTTTAAGCACTTGTTTTTAAAAGGATACTCTGGCA
CGGATGAAGATGACTATAGTTGCAGTGTCTATACTCAAGAGGATGCCTATGAGAGCATCTTTTT
TGCTATCAATCAGTATCATCATCTAAAGAACATATCCCTGGGGACACTCAGTTACGGAGAAAAT
GAAGACAATAGAACTGGCTTGAAAGTCTGTAAGCAGCATTATAAGAAAGGGGCCATGTTTCCTT
CTAATGACACGCTGAACATTGACAGCGACATTGAAGTAGATTGTGTTCACTTAGACCTCTCCAA
GGACCCTCAGGACTGGAAGAACTTGTCATTCTTCAGACTGGAATTTTACCGGCTCTTAGAAGTT
GAAATTTCCTTTCGCCTCAAAGGCATCGACCTACAGACAATTCATTCCCGAGAGTTACCAGACT
GTTACGTCTTTCAGAATACGATTACCTTTGACAATAAAGCTCACAGTGGCAAGATCAAAATTTA
TTTTGACAGTGATGCTAAAATTGAAGAATGTAAAGACTTGAACATATCTGGATCTATTCAGAAA
AATACTCAGTATGTCCTGGTGTTTGATGCATTTGTCATTGTGATTTGCTTGGCATCTCTTATTC
TGTGCACAAGATCCATTGTTCTAGCTCTCAGGTTACGCAAGAGATTTCTAAATTTCTTCCTGGA
GAAGTATAAGCGACGTGTGTGTAACACCGACCAGTGGGAGTTCATCAATGGATGGTATGTCCTG
GTGATTATCAGCGACCTAATGACCATAATTGGATCCATATTAAAAATGGAAATTAAAGCAAAGA
ATCTCACAAATTACGATCTGTGCAGCATTTTGCTCGGAACGTCTACGCTCTTTGTCTGGGTTGG
CGTCATCAGATACCTGGGGTACTTCCAAGCATATAATGTGCTCATTTTAACGATGCAAGCCTCA
CTGCCCAAGGTTCTGCGCTTCTGCGCCTGTGCTGGTATGATCTATCTGGGCTACACGTTCTGTG
GCTGGATTGTCTTAGGACCATATCATGACAAGTTTGAAGATCTGAACACAGTTGCTGAATGTCT
GTTCTCTCTGGTCAATGGCGACGACATGTTTGCGACCTTTGCTGAAATCCAGCAGAAGAGCGTC
CTGGTGTGGCTGTTCAGTCGCCTGTACTTATACTCCTTCATCAGTCTTTTTATATATATGATCC
TCAGTCTGTTCATTGCACTTATTACAGACTCTTATGACACCATTAAGAAATACCAACAGAATGG
GTTTCCTGAAACGGATCTTCAGGAATTCCTGAAGGAATGTAGTAGCAAAGAGAAGTATCAGAAA
GAGTCCTCAGGCTTCTTGTCCTGTGTCTGCTGCCTAAGGAGGAAAGGAAGTGATGACCACTTGA
CACTTGTCAACTAAAATCCTTCTGCTAAAGATAATCGGGCGTCAGGCCTCTTTACCCAGTGACA
ATGCAGAGGGACCCCAAACAACTTGGACCAGCAGTTCCAAAACTCCCAACTTATTTATTTGTGG
AGAGGGAAAGAGGACTGTCACCTGGTTGAACACAACTGAAGTTCCAAAGTTCCTCTTATAAACT
TGGATGATGAAGAATAGACCAGAGTCAACTACTGAGCATTGGTGCAATAGAGCAGTGACAATGA
AATTCTGCATTGGACTTTAATTTATGACATCACAATGCTGGGATGGAAAAAAATGTCACATTTC
AGAGTGTGCAAAAACAATGGCACCTAAAGTCATGCGTTGAAAGTTGTGTGTTTATCATCCAATA
AGGATTTGTTTTAAAAGTGGTTCTTGGACTAGAAGACATTTGTAAATTCATGGTATGCACAGAA
ATGAACTTGGTTGCAATAATAAATTAAAAATTCCAAGCTGGAGAACTATTAAGCCTTTTAAAGA
ATACACTTAAACCAACAAAAAGACCTCTTGTAGTGGACATTTCTGGGCCTGTGTGTGTGTTTGT
TTGTTTCAGCATGACAGGAAGCAGCTGTTGGCATGTTCAGTGAGATAAATTGGAAGCAGAATCA
TTTGGACATGTTGTCATTTGTGCTAATTGTTGATTGTGCACACATGACATGTGGAAATGAACTG
TAGCAGTGGTCACTCCTTTTAACAGTTGAACTCCACTATGGTGGTGATTTACCCTTGTCAAGCA
AGGAAAAATGGTATTTTTTTCCTAAATAAATTTATTTTTTATCACAAAAAAAGGAGTTACTGCT
ATTTTTTTAGTATAATATTTCTTAATATTAACTTAGCGCGAAATTCAGATCACATCTCTTTTGA
CTATCTGGTCTCCAAAAGGGGTATCTCACTTTCTTAAAGGCAGTGAAGGAGGGCTAATATGTAG
AAGGTATTCAATAAATATTTATGATAATGTCTTAA

hide sequence

RefSeq Acc Id:

XM_038480190 ⟹ XP_038336118

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	6	63,021,712 - 63,076,135 (+)	NCBI

RefSeq Acc Id:

XM_038480191 ⟹ XP_038336119

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	6	63,029,932 - 63,076,135 (+)	NCBI

RefSeq Acc Id:

XM_038480192 ⟹ XP_038336120

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	6	63,025,454 - 63,076,135 (+)	NCBI

RefSeq Acc Id:

XM_038480193 ⟹ XP_038336121

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	6	63,025,380 - 63,076,135 (+)	NCBI

RefSeq Acc Id:

XM_038541520 ⟹ XP_038397448

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	6	63,500,378 - 63,551,982 (+)	NCBI

RefSeq Acc Id:

XM_038541521 ⟹ XP_038397449

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	6	63,505,534 - 63,551,982 (+)	NCBI

RefSeq Acc Id:

XM_038541522 ⟹ XP_038397450

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	6	63,501,057 - 63,551,982 (+)	NCBI

RefSeq Acc Id:

XM_038541523 ⟹ XP_038397451

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	6	63,501,004 - 63,551,982 (+)	NCBI

RefSeq Acc Id:

XM_038556350 ⟹ XP_038412278

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	6	65,605,577 - 65,656,536 (+)	NCBI

RefSeq Acc Id:

XM_038556352 ⟹ XP_038412280

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	6	65,605,527 - 65,656,536 (+)	NCBI

RefSeq Acc Id:

XM_038605660 ⟹ XP_038461588

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	6	62,992,176 - 63,043,489 (+)	NCBI

RefSeq Acc Id:

XM_038605661 ⟹ XP_038461589

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	6	62,997,344 - 63,043,489 (+)	NCBI

RefSeq Acc Id:

XM_038605662 ⟹ XP_038461590

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	6	62,992,866 - 63,043,489 (+)	NCBI

RefSeq Acc Id:

XM_038605663 ⟹ XP_038461591

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	6	62,992,792 - 63,043,489 (+)	NCBI

RefSeq Acc Id:

XM_038670264 ⟹ XP_038526192

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	6	63,494,889 - 63,546,421 (+)	NCBI

RefSeq Acc Id:

XM_038670265 ⟹ XP_038526193

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	6	63,500,012 - 63,546,421 (+)	NCBI

RefSeq Acc Id:

XM_038670266 ⟹ XP_038526194

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	6	63,495,550 - 63,546,421 (+)	NCBI

RefSeq Acc Id:

XM_038670267 ⟹ XP_038526195

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	6	63,495,493 - 63,546,421 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005622049	(Get FASTA)	NCBI Sequence Viewer
	XP_005622050	(Get FASTA)	NCBI Sequence Viewer
	XP_038336118	(Get FASTA)	NCBI Sequence Viewer
	XP_038336119	(Get FASTA)	NCBI Sequence Viewer
	XP_038336120	(Get FASTA)	NCBI Sequence Viewer
	XP_038336121	(Get FASTA)	NCBI Sequence Viewer
	XP_038397448	(Get FASTA)	NCBI Sequence Viewer
	XP_038397449	(Get FASTA)	NCBI Sequence Viewer
	XP_038397450	(Get FASTA)	NCBI Sequence Viewer
	XP_038397451	(Get FASTA)	NCBI Sequence Viewer
	XP_038412278	(Get FASTA)	NCBI Sequence Viewer
	XP_038412280	(Get FASTA)	NCBI Sequence Viewer
	XP_038461588	(Get FASTA)	NCBI Sequence Viewer
	XP_038461589	(Get FASTA)	NCBI Sequence Viewer
	XP_038461590	(Get FASTA)	NCBI Sequence Viewer
	XP_038461591	(Get FASTA)	NCBI Sequence Viewer
	XP_038526192	(Get FASTA)	NCBI Sequence Viewer
	XP_038526193	(Get FASTA)	NCBI Sequence Viewer
	XP_038526194	(Get FASTA)	NCBI Sequence Viewer
	XP_038526195	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000030104.4
	ENSCAFP00000053883.2
	ENSCAFP00030024677.1
	ENSCAFP00040018364.1
	ENSCAFP00845001882.1
	ENSCAFP00845001905
	ENSCAFP00845001905.1

RefSeq Acc Id:	XP_005622049 ⟸ XM_005621992
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0NCC2 (UniProtKB/TrEMBL), A0A8I3MYU1 (UniProtKB/TrEMBL), A0A8I3MII8 (UniProtKB/TrEMBL), A0A8P0P3D6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRPGLEALHLPAWSGASGPSWGPRGRNAMAHLDSDVKEECLREDLKFYFMNPCEKYRARHQIPW KLGLQILKIVMVTTQLVRFGLSNQMVVAFKEENTVAFKHLFLKGYSGTDEDDYSCSVYTQEDAY ESIFFAINQYHHLKNISLGTLSYGENEDNRTGLKVCKQHYKKGAMFPSNDTLNIDSDIEVDCVH LDLSKDPQDWKNLSFFRLEFYRLLEVEISFRLKGIDLQTIHSRELPDCYVFQNTITFDNKAHSG KIKIYFDSDAKIEECKDLNISGSIQKNTQYVLVFDAFVIVICLASLILCTRSIVLALRLRKRFL NFFLEKYKRRVCNTDQWEFINGWYVLVIISDLMTIIGSILKMEIKAKNLTNYDLCSILLGTSTL FVWVGVIRYLGYFQAYNVLILTMQASLPKVLRFCACAGMIYLGYTFCGWIVLGPYHDKFEDLNT VAECLFSLVNGDDMFATFAEIQQKSVLVWLFSRLYLYSFISLFIYMILSLFIALITDSYDTIKK YQQNGFPETDLQEFLKECSSKEKYQKESSGFLSCVCCLRRKGSDDHLTLVN hide sequence

RefSeq Acc Id:	XP_005622050 ⟸ XM_005621993
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I3MII8 (UniProtKB/TrEMBL), A0A8P0P3D6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEEEPAKETGKCPVRNAMAHLDSDVKEECLREDLKFYFMNPCEKYRARHQIPWKLGLQILKIVM VTTQLVRFGLSNQMVVAFKEENTVAFKHLFLKGYSGTDEDDYSCSVYTQEDAYESIFFAINQYH HLKNISLGTLSYGENEDNRTGLKVCKQHYKKGAMFPSNDTLNIDSDIEVDCVHLDLSKDPQDWK NLSFFRLEFYRLLEVEISFRLKGIDLQTIHSRELPDCYVFQNTITFDNKAHSGKIKIYFDSDAK IEECKDLNISGSIQKNTQYVLVFDAFVIVICLASLILCTRSIVLALRLRKRFLNFFLEKYKRRV CNTDQWEFINGWYVLVIISDLMTIIGSILKMEIKAKNLTNYDLCSILLGTSTLFVWVGVIRYLG YFQAYNVLILTMQASLPKVLRFCACAGMIYLGYTFCGWIVLGPYHDKFEDLNTVAECLFSLVNG DDMFATFAEIQQKSVLVWLFSRLYLYSFISLFIYMILSLFIALITDSYDTIKKYQQNGFPETDL QEFLKECSSKEKYQKESSGFLSCVCCLRRKGSDDHLTLVN hide sequence

Ensembl Acc Id:

ENSCAFP00000053883 ⟸ ENSCAFT00000064729

Ensembl Acc Id:

ENSCAFP00000030104 ⟸ ENSCAFT00000032327

RefSeq Acc Id:	XP_038336118 ⟸ XM_038480190
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038336121 ⟸ XM_038480193
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038336120 ⟸ XM_038480192
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038336119 ⟸ XM_038480191
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038461588 ⟸ XM_038605660
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038461591 ⟸ XM_038605663
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038461590 ⟸ XM_038605662
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038461589 ⟸ XM_038605661
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038526192 ⟸ XM_038670264
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0NCC2 (UniProtKB/TrEMBL), A0A8I3MYU1 (UniProtKB/TrEMBL), A0A8I3MII8 (UniProtKB/TrEMBL), A0A8P0P3D6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038526195 ⟸ XM_038670267
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I3MII8 (UniProtKB/TrEMBL), A0A8P0P3D6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038526194 ⟸ XM_038670266
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I3MII8 (UniProtKB/TrEMBL), A0A8P0P3D6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038526193 ⟸ XM_038670265
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I3MII8 (UniProtKB/TrEMBL), A0A8P0P3D6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038412280 ⟸ XM_038556352
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I3MII8 (UniProtKB/TrEMBL), A0A8P0P3D6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038412278 ⟸ XM_038556350
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I3MII8 (UniProtKB/TrEMBL), A0A8P0P3D6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038397448 ⟸ XM_038541520
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0NCC2 (UniProtKB/TrEMBL), A0A8I3MII8 (UniProtKB/TrEMBL), A0A8I3MYU1 (UniProtKB/TrEMBL), A0A8P0P3D6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038397451 ⟸ XM_038541523
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I3MII8 (UniProtKB/TrEMBL), A0A8P0P3D6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038397450 ⟸ XM_038541522
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I3MII8 (UniProtKB/TrEMBL), A0A8P0P3D6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038397449 ⟸ XM_038541521
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I3MII8 (UniProtKB/TrEMBL), A0A8P0P3D6 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845001882 ⟸ ENSCAFT00845002367

Ensembl Acc Id:

ENSCAFP00845001905 ⟸ ENSCAFT00845002397

Protein Domains

Mucolipin extracytosolic Polycystin cation channel PKD1/PKD2

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000020297	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030015344	UniProtKB/TrEMBL
	ENSCAFG00040011464	UniProtKB/TrEMBL
	ENSCAFG00845001382	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000032327.5	UniProtKB/TrEMBL
	ENSCAFT00000064729.2	UniProtKB/TrEMBL
	ENSCAFT00030028283.1	UniProtKB/TrEMBL
	ENSCAFT00040021159.1	UniProtKB/TrEMBL
	ENSCAFT00845002367.1	UniProtKB/TrEMBL
	ENSCAFT00845002397	ENTREZGENE
	ENSCAFT00845002397.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.287.70	UniProtKB/TrEMBL
InterPro	MCLN_ECD	UniProtKB/TrEMBL
	Mucolipin	UniProtKB/TrEMBL
	PKD1_2_channel	UniProtKB/TrEMBL
KEGG Report	cfa:490186	UniProtKB/TrEMBL
NCBI Gene	MCOLN2	ENTREZGENE
PANTHER	MUCOLIPIN-2	UniProtKB/TrEMBL
	PTHR12127	UniProtKB/TrEMBL
Pfam	MCLN_ECD	UniProtKB/TrEMBL
	PKD_channel	UniProtKB/TrEMBL
UniProt	A0A8C0NCC2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3MII8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3MYU1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0P3D6	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:111566	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-11-03	MCOLN2	mucolipin TRP cation channel 2	MCOLN2	mucolipin 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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