| 12139666 | EPO | erythropoietin | ENCODES a protein that exhibits erythropoietin receptor binding (ortholog); INVOLVED IN acute-phase response (ortholog); apoptotic process (ortholog); embryo implantation (ortholog); PARTICIPATES IN erythropoietin signaling pathway; hypoxia inducible factor pathway; ASSOCIATED WITH acute kidney fail ure (ortholog); Acute Subdural Hematoma (ortholog); Acute-Phase Reaction (ortholog); FOUND IN cell body (ortholog); extracellular space (ortholog) | 6 | 8994211 | 8995954 | Dog | 195 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12184197 | EPOR | erythropoietin receptor | ENCODES a protein that exhibits erythropoietin receptor activity (ortholog); INVOLVED IN brain development (ortholog); cellular response to kainic acid (ortholog); decidualization (ortholog); PARTICIPATES IN erythropoietin signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); anemia (or tholog); Brain Hypoxia (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog) | 20 | 49945777 | 49950856 | Dog | 84 | symbol , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12333992 | EPOP | elongin BC and polycomb repressive complex 2 associated protein | ENCODES a protein that exhibits chromatin binding (inferred); protein-containing complex binding (inferred); INVOLVED IN neuron fate commitment (ortholog); FOUND IN elongin complex (ortholog); ESC/E(Z) complex (ortholog) | 9 | 23549088 | 23552433 | Dog | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12239792 | CYP2B6 | cytochrome P450 2B11 | ENCODES a protein that exhibits anandamide 11,12 epoxidase activity (ortholog); anandamide 14,15 epoxidase activity (ortholog); anandamide 8,9 epoxidase activity (ortholog); INVOLVED IN ketone metabolic process (ortholog); response to Aroclor 1254 (ortholog); response to bacterium (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH Acute Lymphoblastic Leukemia, with Lymphomatous Features (ortholog); acute myeloid leukemia (ortholog); autism spectrum disorder (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); INTERACTS WITH clofibrate; cyclophosphamide; dextromethorphan | 1 | 112817561 | 112833294 | Dog | 113 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12178746 | EPHX3 | epoxide hydrolase 3 | ENCODES a protein that exhibits catalytic activity (inferred); epoxide hydrolase activity (inferred); hydrolase activity (inferred); INVOLVED IN epoxide metabolic process (inferred); ASSOCIATED WITH melanoma (ortholog); Stom ach Neoplasms (ortholog); FOUND IN membrane (inferred) | 20 | 46932984 | 46935635 | Dog | 9 | name , description | gene, protein-coding, MODEL [RefSeq] |
| 12357026 | VKORC1 | vitamin K epoxide reductase complex subunit 1 | ENCODES a protein that exhibits vitamin-K-epoxide reductase (warfarin-insensitive) activity (ortholog); vitamin-K-epoxide reductase (warfarin-sensitive) activity (ortholog); INVOLVED IN peptidyl-glutamic acid carboxylation ( ortholog); positive regulation of coagulation (ortholog); regulation of blood coagulation (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH Aortic Calcification (ortholog); Aortic Rupture (ortholog); blood coagulation disease (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum lumen (inferred); endoplasmic reticulum membrane (inferred) | 6 | 17140565 | 17142621 | Dog | 62 | name , description | gene, protein-coding, MODEL [RefSeq] |
| 12361972 | SQLE | squalene epoxidase | ENCODES a protein that exhibits squalene monooxygenase activity (ortholog); INVOLVED IN cholesterol metabolic process (ortholog); response to biphenyl (ortholog); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCI ATED WITH cholelithiasis (ortholog); Experimental Liver Neoplasms (ortholog); Hypercholesterolemia (ortholog); FOUND IN cytoplasmic side of endoplasmic reticulum membrane (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred) | 13 | 22994010 | 23018134 | Dog | 55 | name | gene, protein-coding, MODEL [RefSeq] |
| 12279429 | EPHX1 | epoxide hydrolase 1 | ENCODES a protein that exhibits enzyme binding (ortholog); epoxide hydrolase activity (ortholog); oxysterol binding (ortholog); INVOLVED IN cellular response to glucocorticoid stimulus (ortholog); diol biosynthetic process (ortholog); hydrocarbon catabolic proce ss (ortholog); PARTICIPATES IN carbamazepine pharmacokinetics pathway; phenytoin pharmacodynamics pathway; ASSOCIATED WITH Abnormalities, Drug-Induced (ortholog); Acute Lung Injury (ortholog); aflatoxins-related hepatocellular carcinoma (ortholog); FOUND IN membrane (ortholog); INTERACTS WITH styrene oxide | 7 | 38964319 | 39004902 | Dog | 99 | name , description | gene, protein-coding, MODEL [RefSeq] |
| 12231483 | EPHX2 | epoxide hydrolase 2 | ENCODES a protein that exhibits epoxide hydrolase activity (ortholog); magnesium ion binding (ortholog); phosphatase activity (ortholog); INVOLVED IN dephosphorylation (ortholog); linoleic acid metabolic process (ortholog); positive regulation of blood pressure (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); atherosclerosis (ortholog); FOUND IN peroxisome (ortholog); INTERACTS WITH bisphenol A | 25 | 30045040 | 30107110 | Dog | 106 | old_gene_name , name , description | gene, protein-coding, MODEL [RefSeq] |
| 12320761 | EPHX4 | epoxide hydrolase 4 | ENCODES a protein that exhibits catalytic activity (inferred); epoxide hydrolase activity (inferred); hydrolase activity (inferred) | 6 | 56863779 | 56900312 | Dog | 5 | name , description | gene, protein-coding, MODEL [RefSeq] |
| 12406933 | VKORC1L1 | vitamin K epoxide reductase complex subunit 1 like 1 | ENCODES a protein that exhibits oxidoreductase activity (inferred); oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor (inferred); quinone binding (inferred); INVOLVED IN cellular response to oxidative stress (ortholog); peptidyl-glutamic acid carboxylation (ortholog); ASSOCI ATED WITH prostate cancer (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog) | 6 | 661690 | 728813 | Dog | 18 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12101786 | AKR7A2 | aldo-keto reductase family 7 member A2 | ENCODES a protein that exhibits alcohol dehydrogenase (NADP+) activity (ortholog); phenanthrene-9,10-epoxide hydrolase activity (ortholog); INVOLVED IN daunorubicin metabolic process (ortholog); doxorubicin metabolic process (ortholog); ASSOCIATED WITH Alzheimer 's disease (ortholog); autism spectrum disorder (ortholog); pancreatic ductal adenocarcinoma (ortholog); FOUND IN cytosol (ortholog); Golgi apparatus (ortholog); mitochondrion (ortholog) | 2 | 79334179 | 79343880 | Dog | 20 | description | gene, protein-coding, MODEL [RefSeq] |
| 12062036 | ALOX15 | arachidonate 15-lipoxygenase | ENCODES a protein that exhibits arachidonate 12(S)-lipoxygenase activity (ortholog); arachidonate 15-lipoxygenase activity (ortholog); hepoxilin-epoxide hydrolase activity (ortholog); INVOLVED IN arachidonate metabolic proce ss (ortholog); bone mineralization (ortholog); cellular response to calcium ion (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); Alzheimer's disease (ortholog); asthma (ortholog); FOUND IN cytoplasmic side of plasma membrane (ortholog) | 5 | 31883544 | 31891357 | Dog | 131 | description | gene, protein-coding, MODEL [RefSeq] |
| 12184043 | CYP2C41 | cytochrome P450 2C41 | ENCODES a protein that exhibits arachidonate 11,12-epoxygenase activity (ortholog); arachidonate 14,15-epoxygenase activity (ortholog); arachidonate epoxygenase activity (ortholog); INVO LVED IN estrogen metabolic process (ortholog); icosanoid biosynthetic process (ortholog); monocarboxylic acid metabolic process (ortholog); PARTICIPATES IN caffeine pharmacokinetics pathway; celecoxib pharmacodynamics pathway; celecoxib pharmacokinetics pathway; ASSOCIATED WITH acute kidney failure (ortholog); alcohol dependence (ortholog); autism spectrum disorder (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); INTERACTS WITH benzyl alcohol; diclofenac; p-cresol | | | | Dog | 95 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12253071 | CYP4X1 | cytochrome P450 family 4 subfamily X member 1 | ENCODES a protein that exhibits anandamide 14,15 epoxidase activity (inferred); heme binding (inferred); iron ion binding (inferred); ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); membrane (inferred) | 15 | 13509032 | 13546803 | Dog | 12 | description | gene, protein-coding, INFERRED [RefSeq] |