The protein encoded by this gene is multifunctional, affecting trafficking of transducin in rod photoreceptors, interacting with src-type tyrosine kinases through SH2 and SH3 interacting domains, and aiding the uptake of bacteria through endocytosis. In addition, the encoded protein acts as a lipid-
binding chaperone to help localize some myristoylated proteins correctly. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Acts upstream of or within negative regulation of cytokine production involved in inflammatory response; negative regulation of epithelial cell migration; and negative regulation of fibroblast migration. Predicted to be located in ciliary transition zone and cytoplasm. Is expressed in several struct
ures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system. Orthologous to human MACIR (macrophage immunometabolism regulator). [provided by Alliance of Genome Resources, Jul 2025]
Predicted to enable lipid binding activity. Predicted to be involved in cilium assembly; lipoprotein transport; and nervous system development. Predicted to be located in ciliary transition zone. Predicted to be active in cilium. Is expressed in several structures, including central nervous system;
genitourinary system; gut; respiratory system; and sensory organ. Orthologous to human UNC119B (unc-119 lipid binding chaperone B). [provided by Alliance of Genome Resources, Jul 2025]