| 1321368 | Traf2 | TNF receptor-associated factor 2 | Enables CD40 receptor binding activity; signaling adaptor activity; and ubiquitin protein ligase activity. Involved in several processes, including cytokine-mediated signaling pathway; positive regulation of signal transduction; and regulation of gene expression. Acts upstream of or within several p rocesses, including canonical NF-kappaB signal transduction; cellular response to nitric oxide; and regulation of intracellular signal transduction. Located in several cellular components, including cytoplasmic side of plasma membrane; membrane raft; and vesicle membrane. Part of CD40 receptor complex and IRE1-TRAF2-ASK1 complex. Is expressed in several structures, including genitourinary system; liver; lower jaw tooth; and mandibular process. Orthologous to human TRAF2 (TNF receptor associated factor 2). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 25407994 | 25436952 | Mouse | 418 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1558507 | Tnik | TRAF2 and NCK interacting kinase | Predicted to enable protein serine/threonine kinase activity. Involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental diso rder 54. Orthologous to human TNIK (TRAF2 and NCK interacting kinase). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 28317362 | 28724734 | Mouse | 209 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1556897 | Tifa | TRAF-interacting protein with forkhead-associated domain | Involved in positive regulation of canonical NF-kappaB signal transduction and tumor necrosis factor-mediated signaling pathway. Predicted to be active in cytoplasm. Is expressed in several structures, including brain ventricular layer; cerebral cortex subventricular zone; gut; liver; and trigeminal ganglion. Orthologous to human TIFA (TRAF interacting protein with forkhead associated domain). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 127582524 | 127592043 | Mouse | 125 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1318694 | Ern2 | endoplasmic reticulum to nucleus signalling 2 | Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and unfolded protein binding activity. Involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; positive regulation of JUN kinase activity; and regulation of D NA-templated transcription. Located in endoplasmic reticulum quality control compartment. Part of IRE1-TRAF2-ASK1 complex. Is expressed in central nervous system and retina. Orthologous to human ERN2 (endoplasmic reticulum to nucleus signaling 2). [provided by Alliance of Genome Resources, Apr 2025] | 7 | 121769116 | 121785454 | Mouse | 117 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 2308220 | Gstp-ps | glutathione S-transferase, pi, pseudogene | Predicted to enable several functions, including anion binding activity; dinitrosyl-iron complex binding activity; and glutathione peroxidase activity. Predicted to be involved in several processes, including fatty acid metabolic process; negative regulation of cytokine production; and negative regu lation of signal transduction. Predicted to be located in cytosol and mitochondrion. Predicted to be part of TRAF2-GSTP1 complex. [provided by Alliance of Genome Resources, Apr 2025] | 1 | 191758036 | 191762461 | Mouse | 3 | description | gene, protein-coding, MODEL [RefSeq] |
| 1316892 | Gstp3 | glutathione S-transferase pi 3 | Predicted to enable several functions, including anion binding activity; dinitrosyl-iron complex binding activity; and glutathione peroxidase activity. Predicted to be involved in several processes, including fatty acid metabolic process; negative regulation of cytokine production; and negative regu lation of signal transduction. Predicted to be located in mitochondrion. Predicted to be part of TRAF2-GSTP1 complex. Predicted to be active in cytosol. Is expressed in liver lobe. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); carcinoma (multiple); hematologic cancer (multiple); reproductive organ cancer (multiple); and respiratory system disease (multiple). Orthologous to human GSTP1 (glutathione S-transferase pi 1). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 4107470 | 4109587 | Mouse | 76 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1315044 | Map3k5 | mitogen-activated protein kinase kinase kinase 5 | Enables MAP kinase kinase kinase activity and protein kinase binding activity. Involved in several processes, including intracellular signal transduction; positive regulation of JNK cascade; and positive regulation of myoblast differentiation. Acts upstream of or within several processes, including cellular response to reactive nitrogen species; intrinsic apoptotic signaling pathway in response to oxidative stress; and positive regulation of MAPK cascade. Predicted to be located in cytoplasm and external side of plasma membrane. Predicted to be part of IRE1-TRAF2-ASK1 complex and protein kinase complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; heart; and sensory organ. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 19809847 | 20018496 | Mouse | 442 | description | gene, protein-coding, VALIDATED [RefSeq] |
