| 731060 | Rhoa | ras homolog family member A | This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015] | 9 | 108183359 | 108215142 | Mouse | 741 | symbol , old_gene_name , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 1622333 | Lamtor1 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 | Enables protein-membrane adaptor activity. Involved in several processes, including lysosome localization; positive regulation of intracellular signal transduction; and regulation of receptor recycling. Is active in lysosomal membrane. Is expressed in several structures, including adipose tissue; al imentary system; early conceptus; nervous system; and reproductive system. Orthologous to human LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1). [provided by Alliance of Genome Resources, Apr 2025] | 7 | 101555044 | 101561110 | Mouse | 173 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 734041 | Mcf2l | mcf.2 transforming sequence-like | Enables 1-phosphatidylinositol binding activity and guanyl-nucleotide exchange factor activity. Acts upstream of or within Rho protein signal transduction and positive regulation of transcription by RNA polymerase II. Located in lamellipodium and membrane. Is expressed in several structures, includi ng brain; liver; retina; right atrium; and testis. Orthologous to human MCF2L (MCF.2 cell line derived transforming sequence like). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 12923806 | 13070502 | Mouse | 167 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1550862 | Plekhg5 | pleckstrin homology domain containing, family G (with RhoGef domain) member 5 | This gene encodes a protein belonging to the Rho guanine exchange factor (GEF) family of proteins, which activate GTPases by replacing GDP with GTP. This family member is a RhoA GEF that plays a role in endothelial cell migration and tube formation. It is required for angiogenesis and may function i n neuronal cell differentiation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Oct 2013] | 4 | 152156890 | 152199855 | Mouse | 137 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1619220 | Arhgef25 | Rho guanine nucleotide exchange factor 25 | Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in axon guidance. Located in myofibril and plasma membrane. Is expressed in several structures, including brain; eye; gut; metanephros; and otocyst. Orthologous to human ARHGEF25 (Rho guanine nucleotide exchange factor 25). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 127018390 | 127025952 | Mouse | 80 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1614050 | Kctd10 | potassium channel tetramerisation domain containing 10 | Predicted to enable Notch binding activity and identical protein binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Acts upstream of or within angiogenesis; heart development; and negative regulation of Notch signaling pathway. Part of MKS complex. Is expressed in c lavicle; mandible; maxilla; midgut; and rib. Orthologous to human KCTD10 (potassium channel tetramerization domain containing 10). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 114501633 | 114518566 | Mouse | 111 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1332528 | Kctd13 | potassium channel tetramerisation domain containing 13 | Enables identical protein binding activity. Involved in negative regulation of Rho protein signal transduction and positive regulation of synaptic transmission. Predicted to be located in nuclear body. Predicted to be part of Cul3-RING ubiquitin ligase complex. Is expressed in several structures, in cluding central nervous system; genitourinary system; and retina. Orthologous to human KCTD13 (potassium channel tetramerization domain containing 13). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 126528051 | 126544781 | Mouse | 141 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1550978 | Tnfaip1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | Predicted to enable cyclin binding activity; identical protein binding activity; and small GTPase binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including negative regulation of Rho protein signal transduction; posi tive regulation of DNA replication; and stress fiber assembly. Predicted to be located in endosome. Predicted to be part of Cul3-RING ubiquitin ligase complex. Is expressed in brain; heart valve; peripheral nerve; sensory organ; and skeleton. Orthologous to human TNFAIP1 (TNF alpha induced protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 78413676 | 78427122 | Mouse | 139 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1623323 | Rhoay-ps1 | ras homolog A translocated to the Y, pseudogene 1 | | Y | 2095313 | 2096205 | Mouse | | symbol , PhenoGen , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1623322 | Rhoay-ps2 | ras homolog A translocated to the Y, pseudogene 2 | | Y | 3747034 | 3747810 | Mouse | | symbol , PhenoGen , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1623321 | Rhoay-ps3 | ras homolog A translocated to the Y, pseudogene 3 | | Y | 873536 | 874468 | Mouse | | symbol , PhenoGen , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
