| 1313300 | Mdm2 | MDM2 proto-oncogene | Enables p53 binding activity and ubiquitin protein ligase activity. Involved in apoptotic process and positive regulation of muscle cell differentiation. Acts upstream of or within several processes, including blood vessel remodeling; circulatory system development; and traversing start control poin t of mitotic cell cycle. Located in cytoplasm and nucleolus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; endocrine gland cancer (multiple); glioblastoma; ichthyosis; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 117524780 | 117546663 | Mouse | 1033 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1619910 | Mtbp | MDM2 binding protein | Acts upstream of or within negative regulation of cell population proliferation; negative regulation of mitotic nuclear division; and traversing start control point of mitotic cell cycle. Located in kinetochore. Is expressed in cerebellum; cerebral cortex subventricular zone; midbrain ventricular la yer; olfactory cortex ventricular layer; and telencephalon ventricular layer. Orthologous to human MTBP (MDM2 binding protein). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 55420800 | 55489819 | Mouse | 86 | old_gene_name , name , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1319585 | Mdm4 | MDM4 regulator of p53 | This gene encodes a protein that has been shown to negatively regulate the activity of the tumor suppressor protein p53. Homozygous knockout mice exhibit embryonic lethality as a result of p53-dependent apoptosis and cell cycle arrest. Amplification of this gene or overexpression of the encoded prot ein has been linked to a range of human cancers. A pseudogene has been identified on the X chromosome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014] | 1 | 132913843 | 132958325 | Mouse | 274 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1312970 | Tbrg1 | transforming growth factor beta regulated gene 1 | Predicted to be involved in several processes, including DNA replication; protein localization to nucleoplasm; and protein stabilization. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including cranium; genitourinary system; jaw; liver ; and spleen. Orthologous to human TBRG1 (transforming growth factor beta regulator 1). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 37560478 | 37568608 | Mouse | 111 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1313860 | Naa25 | N(alpha)-acetyltransferase 25, NatB auxiliary subunit | Predicted to enable acetyltransferase activator activity. Predicted to be involved in cytoskeleton organization. Predicted to be located in Golgi apparatus and cytosol. Predicted to be part of NatB complex. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; hai r; heart; spinal cord; and stomach. Orthologous to human NAA25 (N-alpha-acetyltransferase 25, NatB auxiliary subunit). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 121535977 | 121580612 | Mouse | 79 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 10322 | Cdkn2a | cyclin dependent kinase inhibitor 2A | Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; MDM2/MDM4 family protein binding activity; and enzyme inhibitor activity. Involved in several processes, including cellular response to gamma radiation ; negative regulation of lymphocyte proliferation; and positive regulation of apoptotic process. Acts upstream of or within several processes, including keratinocyte proliferation; negative regulation of mammary gland epithelial cell proliferation; and negative regulation of protein metabolic process. Located in cytoplasm and granular component. Part of protein-containing complex. Is expressed in several structures, including central nervous system; eye; genitourinary system; immune system; and umbilical artery. Used to study high grade glioma; malignant peripheral nerve sheath tumor; melanoma (multiple); and pancreatic carcinoma (multiple). Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); high grade glioma (multiple); and melanoma (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A). [provided by Alliance of Genome Resources, Apr 2025] | 4 | 89192710 | 89212856 | Mouse | 1223 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1315928 | Psme3 | proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) | Predicted to enable several functions, including MDM2/MDM4 family protein binding activity; endopeptidase activator activity; and p53 binding activity. Predicted to be involved in negative regulation of extrinsic apoptotic signaling pathway; regulation of G1/S t ransition of mitotic cell cycle; and regulation of proteasomal protein catabolic process. Predicted to be located in cytosol. Predicted to be part of proteasome activator complex. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in genitourinary system and ventricular layer. Orthologous to human PSME3 (proteasome activator subunit 3). [provided by Alliance of Genome Resources, Apr 2025] | 11 | 101206090 | 101214363 | Mouse | 167 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1618142 | Rfwd3 | ring finger and WD repeat domain 3 | Predicted to enable MDM2/MDM4 family protein binding activity; p53 binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including DNA metabolic process; regulation of cell cycle phase transition; and response to ionizing radiation. Predicted to be located in nucleoplasm and site of DNA damage. Predicted to colocalize with site of double-strand break. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group W. Orthologous to human RFWD3 (ring finger and WD repeat domain 3). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 111997576 | 112026854 | Mouse | 147 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 5146665 | Rpl37rt | ribosomal protein L37, retrotransposed | Predicted to enable MDM2/MDM4 family protein binding activity; growth factor binding activity; and ubiquitin ligase inhibitor activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in positive regulation of signal transduction b y p53 class mediator. Predicted to be located in cytosolic ribosome. Predicted to be part of cytosolic large ribosomal subunit. Orthologous to human RPL37 (ribosomal protein L37). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 115240981 | 115248327 | Mouse | 12 | description | gene, protein-coding, VALIDATED [RefSeq] |
