Il18 Gene Search Result

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4 records found for search term Il18

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
730895	Il18	interleukin 18	Enables cytokine activity. Involved in several processes, including cholesterol homeostasis; establishment of skin barrier; and positive regulation of cell differentiation. Acts upstream of or within several processes, including natural killer cell mediated cytotoxicity; negative regulation of myobl ... (more) ast differentiation; and positive regulation of type II interferon production. Is active in extracellular space. Is expressed in extraembryonic component; gut; lymphatic system; reproductive system; and trunk. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18). [provided by Alliance of Genome Resources, Apr 2025]	9	50466000	50493141	Mouse	1196	symbol , PhenoGen , description	gene, protein-coding, VALIDATED [RefSeq]
1551696	Il18bp	interleukin 18 binding protein	Predicted to enable interleukin-18 binding activity. Predicted to be involved in T-helper 1 type immune response. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in gut; liver; and male reproductive gland or organ. Human ortholog(s) of thi ... (more) s gene implicated in allergic contact dermatitis and myocardial infarction. Orthologous to human IL18BP (interleukin 18 binding protein). [provided by Alliance of Genome Resources, Jul 2025]	7	101664281	101669699	Mouse	124	symbol , PhenoGen , description	gene, protein-coding, VALIDATED [RefSeq]
1318450	Il18r1	interleukin 18 receptor 1	Enables interleukin-18 receptor activity. Involved in negative regulation of cold-induced thermogenesis and positive regulation of non-canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including T-helper 1 cell differentiation; interleukin-18-mediated signaling p ... (more) athway; and positive regulation of type II interferon production. Predicted to be part of interleukin-18 receptor complex. Predicted to be active in cell surface and plasma membrane. Is expressed in aorta-gonad-mesonephros and thymus primordium. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL18R1 (interleukin 18 receptor 1). [provided by Alliance of Genome Resources, Apr 2025]	1	40504712	40540014	Mouse	157	symbol , PhenoGen , description , old_gene_symbol	gene, protein-coding, VALIDATED [RefSeq]
1315692	Il18rap	interleukin 18 receptor accessory protein	Interleukin-18 (or interferon-gamma inducing factor) is a proinflammatory cytokine that induces cell-mediated immunity following microbial infection. This gene encodes a member of the interleukin-1 receptor family. The encoded protein is an accessory subunit of the receptor for interleukin-18 and me ... (more) diates signaling through this cytokine. Mice lacking this gene exhibit a defective cell-mediated immune response. [provided by RefSeq, Jan 2014]	1	40554548	40590867	Mouse	116	symbol , PhenoGen	gene, protein-coding, VALIDATED [RefSeq]