Enables glutamine synthetase activity. Involved in several processes, including intracellular ammonium homeostasis; positive regulation of erythrocyte differentiation; and regulation of sprouting angiogenesis. Acts upstream of or within cellular response to starvation and response to glucose. Locate
d in cell body; cytoplasm; and glial cell projection. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; sensory organ; and urinary system. Used to study temporal lobe epilepsy. Human ortholog(s) of this gene implicated in congenital glutamine deficiency; epilepsy (multiple); heart disease; and neurodegenerative disease (multiple). Orthologous to human GLUL (glutamate-ammonia ligase). [provided by Alliance of Genome Resources, Jul 2025]
lengsin, lens protein with glutamine synthetase domain
Predicted to enable glutamine synthetase activity. Predicted to be involved in glutamine biosynthetic process. Located in plasma membrane. Orthologous to human LGSN (lengsin, lens protein with glutamine synthetase domain). [provided by Alliance of Genome Resources, Apr 2025]