Lgsn (lengsin, lens protein with glutamine synthetase domain) - Rat Genome Database

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Gene: Lgsn (lengsin, lens protein with glutamine synthetase domain) Mus musculus
Analyze
Symbol: Lgsn
Name: lengsin, lens protein with glutamine synthetase domain
RGD ID: 1332353
MGI Page MGI
Description: Predicted to enable glutamine synthetase activity. Predicted to be involved in glutamine biosynthetic process. Located in plasma membrane. Orthologous to human LGSN (lengsin, lens protein with glutamine synthetase domain).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Glul; Gluld1; glutamate-ammonia ligase (glutamine synthase) domain containing 1; glutamate-ammonia ligase (glutamine synthetase) domain containing 1; glutamate-ammonia ligase domain-containing protein 1; L; le; lengsin; lens glutamine synthase-like; Lgs
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39131,215,362 - 31,243,806 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl131,215,482 - 31,243,806 (+)EnsemblGRCm39 Ensembl
GRCm38131,176,281 - 31,204,725 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl131,176,401 - 31,204,725 (+)EnsemblGRCm38mm10GRCm38
MGSCv37131,233,280 - 31,261,570 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36131,120,981 - 31,149,271 (+)NCBIMGSCv36mm8
Celera130,973,296 - 31,001,446 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map111.53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14681479   PMID:17161372   PMID:18178558   PMID:20107048   PMID:21267068   PMID:21873635  


Genomics

Comparative Map Data
Lgsn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39131,215,362 - 31,243,806 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl131,215,482 - 31,243,806 (+)EnsemblGRCm39 Ensembl
GRCm38131,176,281 - 31,204,725 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl131,176,401 - 31,204,725 (+)EnsemblGRCm38mm10GRCm38
MGSCv37131,233,280 - 31,261,570 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36131,120,981 - 31,149,271 (+)NCBIMGSCv36mm8
Celera130,973,296 - 31,001,446 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map111.53NCBI
LGSN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38663,275,951 - 63,573,607 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl663,275,951 - 63,319,983 (-)EnsemblGRCh38hg38GRCh38
GRCh37663,985,856 - 64,029,888 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36664,047,515 - 64,087,841 (-)NCBINCBI36Build 36hg18NCBI36
Build 34664,047,520 - 64,087,841NCBI
Celera662,145,321 - 62,189,340 (-)NCBICelera
Cytogenetic Map6q12NCBI
HuRef661,165,803 - 61,209,830 (-)NCBIHuRef
CHM1_1664,152,120 - 64,196,163 (-)NCBICHM1_1
T2T-CHM13v2.0664,421,831 - 64,588,322 (-)NCBIT2T-CHM13v2.0
Lgsn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8940,912,398 - 40,943,955 (+)NCBIGRCr8
mRatBN7.2933,416,362 - 33,447,919 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl933,420,484 - 33,447,907 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx941,913,213 - 41,940,643 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0947,045,193 - 47,072,615 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0945,327,050 - 45,354,472 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0937,458,603 - 37,490,117 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl937,462,693 - 37,490,108 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0936,263,149 - 36,294,523 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4929,844,176 - 29,871,557 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1929,845,589 - 29,872,970 (+)NCBI
Celera931,238,716 - 31,265,934 (+)NCBICelera
Cytogenetic Map9q21NCBI
Lgsn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955502483,191 - 552,272 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955502522,492 - 551,842 (+)NCBIChiLan1.0ChiLan1.0
LGSN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2578,141,446 - 78,185,404 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1672,801,340 - 72,845,297 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0660,964,873 - 61,008,833 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1666,235,347 - 66,279,272 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl666,239,052 - 66,280,600 (-)Ensemblpanpan1.1panPan2
LGSN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11226,852,832 - 26,884,307 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1226,852,851 - 26,919,138 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1226,761,476 - 26,792,749 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01227,389,310 - 27,419,270 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1227,389,326 - 27,454,223 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11226,894,374 - 26,924,142 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01226,976,959 - 27,006,723 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01227,074,028 - 27,103,801 (-)NCBIUU_Cfam_GSD_1.0
Lgsn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494662,303,468 - 62,335,915 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364761,624,222 - 1,659,510 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364761,624,287 - 1,656,734 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LGSN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl182,360,774 - 82,387,717 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1182,360,058 - 82,388,479 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2192,641,343 - 92,671,894 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LGSN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11711,419,089 - 11,505,533 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605817,765,855 - 17,806,536 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lgsn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475321,650,655 - 21,679,764 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475321,645,389 - 21,694,557 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lgsn
1616 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:285
Count of miRNA genes:236
Interacting mature miRNAs:268
Transcripts:ENSMUST00000062560, ENSMUST00000161773
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1301011Cplaq4_mcircadian period of locomotor activity 4 (mouse)Not determined1967344243673601Mouse
1301073Orch5_mautoimmune orchitis resistance 5 (mouse)Not determined11906535153065454Mouse
1301275Sle10_msystematic lupus erythematosus susceptibility 10 (mouse)Not determined1288219436882352Mouse
15092046Wngrme1_mweek nine growth rate, maternal effect 1 (mouse)1328014237782236Mouse
11100001Col4a1m1_mcollagen, type IV, alpha 1 modifier 1 (mouse)12555019162946882Mouse
1301370Adip1_madiposity 1 (mouse)Not determined1288219436882352Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
15092044Wtgrme1_mweek ten growth rate, maternal effect 1 (mouse)1328014237782236Mouse
1301240Sluc15_msusceptibility to lung cancer 15 (mouse)Not determined11906535153065454Mouse
1301471Obq2_mobesity QTL 2 (mouse)Not determined1394162037941887Mouse
14700685Civq2_mcerebral infarct volume QTL 2 (mouse)11134048245340482Mouse
1301756Pgia1_mproteoglycan induced arthritis 1 (mouse)Not determined11906535153065454Mouse
15092055Lgrme1_mlate growth rate, maternal effect 1 (mouse)1328014237782236Mouse
12880407V125Dq2_mvitamin D active form serum level QTL 2 (mouse)11933908153339081Mouse
15092050Wsegrme1_mweek seven growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092051Wegrme1_mweek eight growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092048Wsigrme1_mweek six growth rate, maternal effect 1 (mouse)1328014237782236Mouse
1357475w3q13_mweight 3 weeks QTL 13 (mouse)Not determined12310959173976915Mouse
10043970Obq23_mobesity QTL 23 (mouse)Not determined1501266539012665Mouse
12880409V125Dq1_mvitamin D active form serum level QTL 1 (mouse)12603916060039160Mouse
4142433Hbnr1_mHeligmosomoides bakeri nematode resistance 1 (mouse)Not determined2555019158273271Mouse

Markers in Region
fb37c12.x1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38131,200,971 - 31,201,132UniSTSGRCm38
MGSCv37131,257,816 - 31,257,977UniSTSGRCm37
Celera130,997,698 - 30,997,859UniSTS
Cytogenetic Map1BUniSTS
Cytogenetic Map1A5-BUniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000062560   ⟹   ENSMUSP00000059871
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl131,215,482 - 31,243,806 (+)Ensembl
GRCm38.p6 Ensembl131,176,401 - 31,204,725 (+)Ensembl
Ensembl Acc Id: ENSMUST00000161773   ⟹   ENSMUSP00000140063
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl131,228,551 - 31,243,806 (+)Ensembl
GRCm38.p6 Ensembl131,189,470 - 31,204,725 (+)Ensembl
RefSeq Acc Id: NM_153601   ⟹   NP_705829
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39131,215,516 - 31,243,806 (+)NCBI
GRCm38131,176,435 - 31,204,725 (+)ENTREZGENE
MGSCv37131,233,280 - 31,261,570 (+)RGD
Celera130,973,296 - 31,001,446 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030254460   ⟹   XP_030110320
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39131,215,362 - 31,243,806 (+)NCBI
GRCm38131,176,281 - 31,204,725 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030254462   ⟹   XP_030110322
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39131,228,445 - 31,243,806 (+)NCBI
GRCm38131,189,364 - 31,204,725 (+)NCBI
Sequence:
RefSeq Acc Id: NP_705829   ⟸   NM_153601
- UniProtKB: Q149K1 (UniProtKB/Swiss-Prot),   Q8CIX8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030110320   ⟸   XM_030254460
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030110322   ⟸   XM_030254462
- Peptide Label: isoform X1
Ensembl Acc Id: ENSMUSP00000059871   ⟸   ENSMUST00000062560
Ensembl Acc Id: ENSMUSP00000140063   ⟸   ENSMUST00000161773
Protein Domains
GS beta-grasp   GS catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CIX8-F1-model_v2 AlphaFold Q8CIX8 1-563 view protein structure

Promoters
RGD ID:6873352
Promoter ID:EPDNEW_M127
Type:single initiation site
Name:Lgsn_1
Description:Mus musculus lengsin, lens protein with glutamine synthetasedomain , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38131,176,409 - 31,176,469EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2672844 AgrOrtholog
Ensembl Genes ENSMUSG00000050217 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000062560 ENTREZGENE
  ENSMUST00000062560.14 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.20.70 UniProtKB/Swiss-Prot
  Glutamine synthetase/guanido kinase, catalytic domain UniProtKB/Swiss-Prot
InterPro Gln_synt_N UniProtKB/Swiss-Prot
  Gln_synt_N UniProtKB/Swiss-Prot
  Gln_synth/guanido_kin_cat_dom UniProtKB/Swiss-Prot
  Gln_synth_cat_dom UniProtKB/Swiss-Prot
KEGG Report mmu:266744 UniProtKB/Swiss-Prot
MGD MGI:2672844 ENTREZGENE
NCBI Gene 266744 ENTREZGENE
PANTHER GLUTAMINE SYNTHETASE UniProtKB/Swiss-Prot
  LENGSIN UniProtKB/Swiss-Prot
Pfam Gln-synt_C UniProtKB/Swiss-Prot
PhenoGen Lgsn PhenoGen
PROSITE GS_BETA_GRASP UniProtKB/Swiss-Prot
  GS_CATALYTIC UniProtKB/Swiss-Prot
SMART Gln-synt_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54368 UniProtKB/Swiss-Prot
  SSF55931 UniProtKB/Swiss-Prot
UniProt A0A087WQ68_MOUSE UniProtKB/TrEMBL
  LGSN_MOUSE UniProtKB/Swiss-Prot
  Q149K1 ENTREZGENE
  Q8CIX8 ENTREZGENE
UniProt Secondary Q149K1 UniProtKB/Swiss-Prot