| 10626 | Gcg | glucagon | This gene encodes glucagon, a pancreatic hormone that counteracts the action of insulin in the bloodstream. The encoded protein is processed to generate glucagon and two other glucagon-like peptides, GLP1 and GLP2. Glucagon stimulates gluconeogenesis, glycogenolysis and lipolysis. GLP1 induces secre tion of insulin, suppresses glucagon secretion and inhibits feeding. GLP2 induces intestinal absorption of glucose by stimulating the growth of intestinal cells and preventing apoptosis. [provided by RefSeq, Apr 2015] | 2 | 62304874 | 62313997 | Mouse | 269 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 1316176 | Chac1 | ChaC, cation transport regulator 1 | Enables Notch binding activity. Involved in neurogenesis. Acts upstream of or within response to caloric restriction. Located in trans-Golgi network. Is expressed in several structures, including bone; brain; gonad; hemolymphoid system gland; and neural ectoderm. Orthologous to human CHAC1 (ChaC glu tathione specific gamma-glutamylcyclotransferase 1). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 119181723 | 119184807 | Mouse | 308 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1319283 | Chac2 | ChaC, cation transport regulator 2 | Predicted to enable glutathione specific gamma-glutamylcyclotransferase activity. Predicted to be involved in glutathione catabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human CHAC2 (ChaC glutathione specific gamma-glutamylcyclotransferase 2 ). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 30926707 | 30936365 | Mouse | 122 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1332263 | Gcgr | glucagon receptor | Enables glucagon receptor activity. Involved in several processes, including cellular response to glucagon stimulus; glucose homeostasis; and regulation of glycogen metabolic process. Acts upstream of or within cellular response to starvation and positive regulation of gene expression. Is active in plasma membrane. Is expressed in several structures, including brain; foot mesenchyme; gut; liver; and male reproductive gland or organ. Used to study Mahvash Disease. Human ortholog(s) of this gene implicated in Mahvash Disease and type 2 diabetes mellitus. Orthologous to human GCGR (glucagon receptor). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 120420011 | 120429815 | Mouse | 270 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |