| 731930 | Fyn | Fyn proto-oncogene, Src family tyrosine kinase | Enables several functions, including cytoskeletal protein binding activity; protein tyrosine kinase activity; and transmembrane transporter binding activity. Involved in several processes, including negative regulation of dendritic spine maintenance; positive regulation of tyrosine phosphorylation o f STAT protein; and reelin-mediated signaling pathway. Acts upstream of or within several processes, including activated T cell proliferation; negative regulation of protein metabolic process; and nervous system development. Located in several cellular components, including actin filament; membrane raft; and postsynaptic density. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study skin disease and skin squamous cell carcinoma. Human ortholog(s) of this gene implicated in Alzheimer's disease; alcohol dependence; and schizophrenia. Orthologous to human FYN (FYN proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 39245735 | 39441377 | Mouse | 660 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1624094 | Frk | fyn-related kinase | Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in cell differentiation; cell surface receptor protein tyrosine kinase signaling pathway; and negative regulation of transcription by RNA polymerase II. Predic ted to be located in cytosol and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Orthologous to human FRK (fyn related Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2025] | 10 | 34359396 | 34487530 | Mouse | 121 | name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1316290 | Fyb1 | FYN binding protein 1 | The protein encoded by this gene is an adapter molecule that affects T cell receptor signaling and contains multiple protein-protein interaction domains. It is thought to couple T cell receptor stimulation with activation of integrin function. Alternative splicing results in multiple transcript vari ants encoding different isoforms. [provided by RefSeq, May 2013] | 15 | 6552280 | 6695089 | Mouse | 131 | old_gene_name , name | gene, protein-coding, REVIEWED [RefSeq] |
| 1618117 | Fyb2 | FYN binding protein 2 | Predicted to be involved in cell adhesion mediated by integrin; cell surface receptor signaling pathway; and protein localization to plasma membrane. Predicted to be located in immunological synapse and membrane raft. Predicted to be active in plasma membrane. Orthologous to human FYB2 (FYN 'font-weight:700;'>FYN binding protein 2). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 104692431 | 104874061 | Mouse | 68 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1319048 | Efs | embryonal Fyn-associated substrate | Enables SH3 domain binding activity. Predicted to be involved in cell migration and cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be active in cytoplasm and focal adhesion. Predicted to colocalize with plasma membrane. Is expressed in several structures, including ali mentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Used to study Crohn's disease. Orthologous to human EFS (embryonal Fyn-associated substrate). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 55154087 | 55164222 | Mouse | 94 | name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1623765 | Gpatch8 | G patch domain containing 8 | Enables mRNA binding activity. Acts upstream of or within hemopoiesis and mRNA splicing, via spliceosome. Predicted to be active in nucleus. Is expressed in brain; cerebellum; and forebrain. Orthologous to human GPATCH8 (G-patch domain containing 8). [provided by Alliance of Genome Resources, Jul 20 25] | 11 | 102366737 | 102447217 | Mouse | 67 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1323506 | Rbfox2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | Enables mRNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome and regulation of definitive erythrocyte differentiation. Acts upstream of or within dendrite morphogenesis; neuromuscular process controlling balance; and radial glia guided migration of Purkinje cel l. Located in nucleus. Is expressed in several structures, including blastocyst; brain; dorsal root ganglion; early embryo; and limb. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human RBFOX2 (RNA binding fox-1 homolog 2). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 76963190 | 77193058 | Mouse | 246 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
