| 1622283 | Dram1 | DNA-damage regulated autophagy modulator 1 | Predicted to be involved in regulation of autophagy. Predicted to be located in cytoplasm. Predicted to be active in lysosome. Is expressed in several structures, including adipose tissue; genitourinary system; gut; integumental system; and respiratory system. Human ortholog(s) of this gene implicat ed in acute myocardial infarction. Orthologous to human DRAM1 (DNA damage regulated autophagy modulator 1). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 88158663 | 88200218 | Mouse | 148 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1617548 | Dram2 | DNA-damage regulated autophagy modulator 2 | Involved in photoreceptor cell maintenance. Acts upstream of or within cell population proliferation; phloem or xylem histogenesis; and retina development in camera-type eye. Located in apical plasma membrane and photoreceptor inner segment. Is expressed in several structures, including alimentary s ystem; eye; genitourinary system; hemolymphoid system gland; and nervous system. Used to study cone-rod dystrophy. Human ortholog(s) of this gene implicated in cone-rod dystrophy 21. Orthologous to human DRAM2 (DNA damage regulated autophagy modulator 2). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 106455114 | 106482657 | Mouse | 111 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 732911 | Cdkn1a | cyclin dependent kinase inhibitor 1A | This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at the G1 pahse. The expression of this gene is t ightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] | 17 | 29309953 | 29319696 | Mouse | 2388 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 10940 | Myc | Myc proto-oncogene, bHLH transcription factor | The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010] | 15 | 61857190 | 61862210 | Mouse | 1643 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 11170 | Prh1 | proline rich protein HaeIII subfamily 1 | This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The expression of this gene is dramatically induced in the parotid and submandibular glands of mice by beta-adrenergic stimulation. The encoded protein serves an impor tant dental function by protecting mice against toxic dietary polyphenols such as tannins and influence the visco-elastic properties of the mucus. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 6. [provided by RefSeq, Nov 2015] | 6 | 132546805 | 132549364 | Mouse | 26 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1312903 | Prp2 | proline rich protein 2 | This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The expression of this gene is dramatically induced in the parotid and submandibular glands of mice by beta-adrenergic stimulation. The encoded protein serves an impor tant dental function by protecting mice against toxic dietary polyphenols such as tannins and influence the visco-elastic properties of the mucus. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 6. [provided by RefSeq, Nov 2015] | 6 | 132572874 | 132577665 | Mouse | 15 | description | gene, protein-coding, REVIEWED [RefSeq] |
