betacellulin, epidermal growth factor family member
This gene encodes a member of the epidermal growth factor (EGF) family. These growth factors are ligands for the EGFR/ErbB receptor tyrosine kinases, and play roles in cell growth and differentiation. The encoded protein is synthesized as a transmembrane precursor that is proteolytically cleaved to
generate a mature peptide, and plays a role in the differentiation of pancreatic beta cells. This gene may also play a protective role in acute pancreatitis, whereas increased expression of this gene may contribute to diabetic macular edema. Gene therapy using combinations of this gene and other pancreas-specific transcription factors may induce islet neogenesis and remediate hyperglycemia in type 1 diabetes. [provided by RefSeq, Apr 2011]
Enables ionotropic glutamate receptor binding activity. Involved in learning or memory; modulation of chemical synaptic transmission; and protein localization to synapse. Acts upstream of or within positive regulation of excitatory postsynaptic potential and receptor localization to synapse. Located
in excitatory synapse and postsynaptic density. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in central nervous system and retina inner nuclear layer. Orthologous to human NETO1 (neuropilin and tolloid like 1). [provided by Alliance of Genome Resources, Jul 2025]
Enables ionotropic glutamate receptor binding activity. Predicted to be involved in neurotransmitter receptor localization to postsynaptic specialization membrane and regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Located in postsynaptic density. Is act
ive in glutamatergic synapse and postsynaptic density membrane. Is expressed in central nervous system and retina. Orthologous to human NETO2 (neuropilin and tolloid like 2). [provided by Alliance of Genome Resources, Jul 2025]