| 1318206 | USP5 | ubiquitin specific peptidase 5 | Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquit in chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010] | 12 | 6852150 | 6866632 | Human | 155 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 16565930 | AL137190.1 | ubiquitin specific peptidase 5 (isopeptidase T) (USP5) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 1343119 | USP50 | ubiquitin specific peptidase 50 | Enables cysteine-type deubiquitinase activity. Involved in regulation of cell cycle G2/M phase transition. Acts upstream of or within several processes, including nuclear speck organization; positive regulation of NLRP3 inflammasome complex assembly; and positive regulation of interleukin-1 beta pro duction. Located in centrosome; cytoplasm; and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 15 | 50493025 | 50546666 | Human | 45 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1603172 | USP51 | ubiquitin specific peptidase 51 | Enables chromatin binding activity; deubiquitinase activity; and histone binding activity. Involved in DNA repair-dependent chromatin remodeling; regulation of cell cycle process; and regulation of double-strand break repair. Predicted to be located in chromosome. [provided by Alliance of Genome Res ources, Jul 2025] | X | 55484616 | 55489848 | Human | 67 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1315332 | USP53 | ubiquitin specific peptidase 53 | Enables K63-linked deubiquitinase activity. Predicted to be involved in response to auditory stimulus and sensory perception of sound. Predicted to act upstream of or within action potential; epithelial cell apoptotic process; and outer hair cell apoptotic process. Located in bicellular tight juncti on. Implicated in progressive familial intrahepatic cholestasis. [provided by Alliance of Genome Resources, Jul 2025] | 4 | 119212601 | 119295518 | Human | 161 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1343407 | USP54 | ubiquitin specific peptidase 54 | Enables K63-linked deubiquitinase activity and cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination and proteolysis. [provided by Alliance of Genome Resources, Jul 2025] | 10 | 73497538 | 73625981 | Human | 78 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 38616286 | USP53-DT | USP53 divergent transcript | | 4 | 119192773 | 119212644 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1348496 | PAN2 | poly(A) specific ribonuclease subunit PAN2 | This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] | 12 | 56316936 | 56334000 | Human | 121 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 8662489 | PPP3CB-AS1 | PPP3CB antisense RNA 1 | INTERACTS WITH sodium arsenite; thiram | 10 | 73495752 | 73507309 | Human | 2 | old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 16565003 | AC073389.1 | novel transcript, antisense to USP54 | | | | | Human | | name | gene, lncrna |