| 1346837 | TRAP1 | TNF receptor associated protein 1 | This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in mu ltiple transcript variants. [provided by RefSeq, Jan 2013] | 16 | 3658037 | 3717524 | Human | 213 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1347885 | HSP90B2P | heat shock protein 90 beta family member 2, pseudogene | Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be active in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025] | 15 | 99257525 | 99260276 | Human | 21 | old_gene_symbol | gene, pseudo, VALIDATED [RefSeq] |
| 1321869 | TGFBRAP1 | transforming growth factor beta receptor associated protein 1 | This gene encodes a protein that binds to transforming growth factor-beta (TGF-beta) receptors and plays a role in TGF-beta signaling. The encoded protein acts as a chaprone in signaling downstream of TGF-beta. It is involved in signal-dependent association with SMAD4. The protein is also a componen t of mammalian CORVET, a multisubunit tethering protein complex that is involved in fusion of early endosomes. [provided by RefSeq, Jun 2016] | 2 | 105249404 | 105329735 | Human | 85 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 16567988 | AC006111.3 | novel transcript, antisense to TRAP1 | | | | | Human | | name | gene, lncrna |
| 16563698 | AC006111.2 | novel transcript, sense overlapping TRAP1 | | | | | Human | | name | gene, lncrna |
| 1312537 | VPS39 | VPS39 subunit of HOPS complex | This gene encodes a protein that may promote clustering and fusion of late endosomes and lysosomes. The protein may also act as an adaptor protein that modulates the transforming growth factor-beta response by coupling the transforming growth factor-beta receptor complex to the Smad pathway. Alterna tive splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] | 15 | 42158701 | 42208304 | Human | 105 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1343127 | MED14 | mediator complex subunit 14 | The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. [provided by RefSeq, Jul 2008] | X | 40648305 | 40736159 | Human | 106 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1348876 | MED24 | mediator complex subunit 24 | This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene exp ression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 17 | 40019104 | 40054408 | Human | 91 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1314565 | THRAP3 | thyroid hormone receptor associated protein 3 | Enables nuclear thyroid hormone receptor binding activity; phosphoprotein binding activity; and transcription coactivator activity. Involved in positive regulation of circadian rhythm and regulation of gene expression. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in exon-exon junction complex and nuclear speck. Part of mediator complex. [provided by Alliance of Genome Resources, Jul 2025] | 1 | 36207637 | 36305357 | Human | 124 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1316342 | HSP90AA2P | heat shock protein 90 alpha family class A member 2, pseudogene | HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizin g and refolding denatured proteins after stress. HSP90AA2 is a cytosolic HSP90 protein. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]). See HSP90AA1 (MIM 140571) for further information on HSP90 proteins.[supplied by OMIM, Aug 2008] | 11 | 27888171 | 27891092 | Human | 36 | description | gene, pseudo, INFERRED [RefSeq] |
