| 1351195 | RHOB | ras homolog family member B | Predicted to enable GTP binding activity and GTPase activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to ionizing radiation; and regulation of cell migration. Located in cleavage furrow and endosome membrane. Biomarker of breast cancer. [pro vided by Alliance of Genome Resources, Jul 2025] | 2 | 20447074 | 20449440 | Human | 355 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 16560730 | AP000857.1 | ras homolog gene family, member B (RHOB) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 1318093 | RHPN2 | rhophilin Rho GTPase binding protein 2 | This gene encodes a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins. The encoded protein binds both GTP- and GDP-bound RhoA and GTP-bound RhoB and may be involved in the organization of the actin cytoskeleton. [provided by RefSeq, Apr 2009] | 19 | 32978592 | 33064888 | Human | 106 | old_gene_name , description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1315735 | RHOBTB1 | Rho related BTB domain containing 1 | The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008] | 10 | 60860860 | 61001967 | Human | 156 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1320529 | RHOBTB2 | Rho related BTB domain containing 2 | The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript va riants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] | 8 | 22950813 | 23020199 | Human | 252 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1323267 | RHOBTB3 | Rho related BTB domain containing 3 | Enables ATP binding activity; ATP hydrolysis activity; and small GTPase binding activity. Involved in retrograde transport, endosome to Golgi. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025] | 5 | 95717624 | 95796361 | Human | 153 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 38620675 | RHOBTB2-AS1 | RHOBTB2 antisense RNA 1 | | 8 | 22953619 | 22999805 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1321712 | ARHGEF3 | Rho guanine nucleotide exchange factor 3 | Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 3 | 56727420 | 57079268 | Human | 136 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 16557946 | AC107959.1 | novel transcript, antisense to RHOBTB2 | | | | | Human | | name | gene, lncrna |