| 1322687 | PRPF4 | pre-mRNA splicing tri-snRNP complex factor PRPF4 | The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of chemoresistance in human ovarian cancer. Several transcript variants encodi ng different isoforms have been found for this gene. [provided by RefSeq, Apr 2016] | 9 | 113275658 | 113292905 | Human | 165 | symbol , COSMIC , name , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1322844 | PRPF40A | pre-mRNA processing factor 40A | Enables RNA binding activity. Involved in several processes, including cytoskeleton organization; regulation of cell shape; and regulation of cytokinesis. Located in nuclear matrix and nuclear speck. [provided by Alliance of Genome Resources, Jul 2025] | 2 | 152651732 | 152718019 | Human | 116 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1604375 | PRPF40B | pre-mRNA processing factor 40B | This gene encodes a WW-domain containing protein similar to yeast splicing factor PRP40. This protein has been shown to interact with Huntingtin and methyl CpG binding protein 2 (MeCP2). Alternative splicing results in different transcript variants. [provided by RefSeq, Aug 2014] | 12 | 49622646 | 49644665 | Human | 55 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 28912506 | PRPF4BP1 | PRPF4B pseudogene 1 | | X | 116748140 | 116748877 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16552818 | PRPF4BP1 | PRPF4B pseudogene 1 | | | | | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, processed_pseudogene |
| 1317633 | DHX15 | DEAH-box helicase 15 | The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing. [provided by RefSeq, Jul 2008] | 4 | 24527475 | 24584554 | Human | 149 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 733629 | PLRG1 | pleiotropic regulator 1 | This gene encodes a core component of the cell division cycle 5-like (CDC5L) complex. The CDC5L complex is part of the spliceosome and is required for pre-mRNA splicing. The encoded protein plays a critical role in alternative splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] | 4 | 154535005 | 154550400 | Human | 100 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1317177 | PRP4K | pre-mRNA processing factor kinase PRP4K | Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-depende nt kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008] | 6 | 4021300 | 4064983 | Human | 143 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1321977 | SNW1 | SNW domain containing 1 | This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-me diated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] | 14 | 77717599 | 77761156 | Human | 155 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1347300 | PPIH | peptidylprolyl isomerase H | The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that incl udes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008] | 1 | 42658423 | 42681654 | Human | 118 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 16561491 | AC020612.2 | novel transcript, antisense to PRPF40B | | | | | Human | | name | gene, lncrna |
| 16554527 | AL133412.1 | PRP4 pre-mRNA processing factor 4 homolog B (PRPF4B) pseudogene | | 9 | 114845490 | 114848788 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
