| 1323231 | PDCD1 | programmed cell death 1 | Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiatio n of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020] | 2 | 241849884 | 241858894 | Human | 256 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1605963 | VSIR | V-set immunoregulatory receptor | Enables endopeptidase activator activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of metabolic process; and regulation of T cell activation. Located in plasma membrane. [ provided by Alliance of Genome Resources, Jul 2025] | 10 | 71747556 | 71773520 | Human | 109 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1605684 | CD274 | CD274 molecule | This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] | 9 | 5450542 | 5470554 | Human | 325 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1314998 | PDCD1LG2 | programmed cell death 1 ligand 2 | Involved in negative regulation of activated T cell proliferation; negative regulation of interleukin-10 production; and negative regulation of type II interferon production. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of pulmonar y tuberculosis. [provided by Alliance of Genome Resources, Jul 2025] | 9 | 5510531 | 5571282 | Human | 87 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1351056 | PDCD10 | programmed cell death 10 | This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, an d is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] | 3 | 167683298 | 167734892 | Human | 250 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1354347 | PDCD11 | programmed cell death 11 | PDCD11 is a NF-kappa-B (NFKB1; 164011)-binding protein that colocalizes with U3 RNA (MIM 180710) in the nucleolus and is required for rRNA maturation and generation of 18S rRNA (Sweet et al., 2003 [PubMed 14624448]; Sweet et al., 2008 [PubMed 17654514]).[supplie d by OMIM, Oct 2008] | 10 | 103396626 | 103446294 | Human | 100 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1320536 | AVEN | apoptosis and caspase activation inhibitor | Involved in negative regulation of apoptotic process. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025] | 15 | 33851781 | 34075325 | Human | 94 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1602474 | PGCKA1 | PDCD10 and GCKIII kinases associated 1 | INVOLVED IN regulation of cell cycle; ASSOCIATED WITH cholestasis; FOUND IN cell periphery; INTERACTS WITH 17beta-estradiol; 3-methylcholanthrene; 4,4'-sulfonyldiphenol | 4 | 37453255 | 37593510 | Human | 52 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 16559702 | AC087272.1 | programmed cell death 10 (PDCD10) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
