Pawr Gene Search Result

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5 records found for search term Pawr

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
69120	PAWR	pro-apoptotic WT1 regulator	This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mecha ... (more) nism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017]	12	79584879	79690964	Human	229	symbol , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
16566047	AC138894.3	PRKC, apoptosis, WT1, regulator (PAWR) pseudogene					Human		name	gene, processed_pseudogene
7250955	PAWRP2	pro-apoptotic WT1 regulator pseudogene 2		16	28749962	28750595	Human		symbol , old_gene_name , COSMIC , Human Proteome Map	gene, pseudo, INFERRED [RefSeq]
7255810	PAWRP1	pro-apoptotic WT1 regulator pseudogene 1		10	95183648	95184219	Human		symbol , COSMIC , Human Proteome Map	gene, pseudo, INFERRED [RefSeq]
1316870	THAP1	THAP domain containing 1	The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links ... (more) an style='font-weight:700;'>PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]	8	42836674	42843325	Human	181	description	gene, protein-coding, REVIEWED [RefSeq]