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Gene: PAWR (pro-apoptotic WT1 regulator) Homo sapiens
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Symbol: PAWR
Name: pro-apoptotic WT1 regulator
Description: Exhibits enzyme binding activity and leucine zipper domain binding activity. Predicted to be involved in actin filament bundle assembly; apoptotic process; and positive regulation of apoptotic process. Localizes to several cellular components, including the actin cytoskeleton; nucleus; and plasma membrane. Biomarker of Alzheimer's disease; cholangiocarcinoma; and major depressive disorder.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Par-4; PAR4; PRKC apoptosis WT1 regulator protein; PRKC, apoptosis, WT1, regulator; prostate apoptosis response 4 protein; prostate apoptosis response protein 4; prostate apoptosis response protein PAR-4; prostate apoptosis response-4; transcriptional repressor PAR4; WT1-interacting protein
Orthologs:
Mus musculus (house mouse) : Pawr (PRKC, apoptosis, WT1, regulator)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pawr (pro-apoptotic WT1 regulator)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pawr (pro-apoptotic WT1 regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : PAWR (pro-apoptotic WT1 regulator)
Canis lupus familiaris (dog) : PAWR (pro-apoptotic WT1 regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pawr (pro-apoptotic WT1 regulator)
Sus scrofa (pig) : PAWR (pro-apoptotic WT1 regulator)
Chlorocebus sabaeus (green monkey) : PAWR (pro-apoptotic WT1 regulator)
Heterocephalus glaber (naked mole-rat) : Pawr (pro-apoptotic WT1 regulator)
more info ...
Related Pseudogenes: PAWRP1   PAWRP2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1279,574,979 - 79,690,964 (-)Ensembl
GRCh381279,584,874 - 79,691,097 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371279,985,745 - 80,084,877 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361278,509,876 - 78,608,921 (-)NCBINCBI36hg18NCBI36
Build 341278,488,214 - 78,587,258NCBI
Celera1279,652,459 - 79,751,312 (-)NCBI
Cytogenetic Map12q21.2NCBI
HuRef1277,042,009 - 77,141,117 (-)NCBIHuRef
CHM1_11279,952,168 - 80,051,122 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PAWR
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69120
Created: 2001-11-08
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.