Oaz2 Gene Search Result

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4 records found for search term Oaz2

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1344023	OAZ2	ornithine decarboxylase antizyme 2	The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamines. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes ... (more) in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]	15	64687574	64703281	Human	96	symbol , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
16562321	AC100830.1	novel transcript, antisense OAZ2					Human		name	gene, lncrna
16563996	AC100830.2	novel transcript, antisense to ornithine decarboxylase antizyme 2 OAZ2					Human		name	gene, lncrna
16564163	AC100830.3	novel transcript, antisense to ornithine decarboxylase antizyme 2 OAZ2					Human		name	gene, lncrna