| 734203 | MIF | macrophage migration inhibitory factor | This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008] | 22 | 23894383 | 23895223 | Human | 498 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 9479125 | MIF-AS1 | MIF antisense RNA 1 | INTERACTS WITH acrylamide; aristolochic acid A; sodium arsenite | 22 | 23893710 | 23898930 | Human | 3 | symbol , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 736161 | AMH | anti-Mullerian hormone | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome. [provided by RefSeq, Jul 2016] | 19 | 2249323 | 2252073 | Human | 241 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1349531 | S100A8 | S100 calcium binding protein A8 | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progressi on and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] | 1 | 153390032 | 153422583 | Human | 428 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1352981 | S100A9 | S100 calcium binding protein A9 | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progressi on and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis. This antimicrobial protein exhibits antifungal and antibacterial activity. [provided by RefSeq, Nov 2014] | 1 | 153357854 | 153361023 | Human | 441 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1353002 | DDT | D-dopachrome tautomerase | D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely lin ked on chromosome 22. [provided by RefSeq, Jul 2008] | 22 | 23971370 | 23980504 | Human | 128 | description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 13801140 | ODC1-DT | ODC1 divergent transcript | INTERACTS WITH sodium arsenite | 2 | 10449728 | 10455552 | Human | 1 | old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 16555692 | AL451062.1 | SMT3 suppressor of mif two 3 (yeast) family pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16552765 | AL390728.3 | SMT3 suppressor of mif two 3 homolog 3 (yeast) (SUMO3) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16556153 | AL008629.1 | pseudogene similar to part of SMT3 suppressor of mif two 3 (yeast) | | | | | Human | | name | gene, processed_pseudogene |
| 16554250 | AL009048.1 | SMT3 suppressor of mif two 3 homolog 1 (yeast) (SMT3H1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16557791 | FO393419.3 | SMT3 suppressor of mif two 3 homolog 2 (yeast) (SMT3H2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16564852 | AC012254.4 | SUMO2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae), pseudogene | | 18 | 47136915 | 47137284 | Human | | name | gene, pseudo, MODEL [RefSeq] |
| 16553824 | AC002542.1 | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) (SUMO2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16561713 | AC006349.1 | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) (SUMO2) pseudogene | | | | | Human | | name | gene, transcribed_processed_pseudogene |
| 16552054 | AC010493.1 | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) (SUMO1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16555232 | AC011233.1 | SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae) (SUMO3) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16560180 | AC025755.1 | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) (SUMO2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16562456 | AC034105.2 | SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae) (SUMO3) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16562763 | AC074050.1 | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) (SUMO2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16552797 | AC079809.1 | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) (SUMO2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16562130 | AC084759.1 | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) (SUMO2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16561702 | AL121603.1 | SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae) (SUMO4) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16552450 | AL121834.1 | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) (SUMO2) pseudogene | | | | | Human | | name | gene, transcribed_processed_pseudogene |
| 16552405 | AL451046.2 | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) (SUMO1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16560494 | AP003168.1 | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) (SUMO1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 1315807 | SUMO1 | small ubiquitin like modifier 1 | This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degr adation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008] | 2 | 202206171 | 202238597 | Human | 300 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1346569 | SUMO2 | small ubiquitin like modifier 2 | This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degr adation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] | 17 | 75165586 | 75182959 | Human | 145 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1346388 | SUMO3 | small ubiquitin like modifier 3 | This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, inclu ding nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014] | 21 | 44805617 | 44818062 | Human | 108 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1349888 | SUMO4 | small ubiquitin like modifier 4 | This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifica lly modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008] | 6 | 149400262 | 149401278 | Human | 34 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 4144231 | SUMO2P7 | SUMO2 pseudogene 7 | | 17 | 50235749 | 50236350 | Human | | old_gene_name | gene, pseudo, INFERRED [RefSeq] |
| 1606529 | MIF4GD | MIF4G domain containing | This gene encodes a protein which interacts with the N-terminus of the stem-loop binding protein (SLBP) and the 3' end of histone mRNA. This interaction facilitates the activation of histone mRNA translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [ provided by RefSeq, Jun 2011] | 17 | 75266228 | 75271292 | Human | 100 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 16563810 | MIF4GD-DT | MIF4GD divergent transcript | | 17 | 75271299 | 75273895 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1354407 | CENPC | centromere protein C | Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008] | 4 | 67468762 | 67545503 | Human | 99 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 733943 | HERPUD1 | homocysteine inducible ER protein with ubiquitin like domain 1 | The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfol ded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq, Jan 2013] | 16 | 56932142 | 56944864 | Human | 294 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 736447 | HSPA5 | heat shock protein family A (Hsp70) member 5 | The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER ho meostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers. [provided by RefSeq, Jul 2020] | 9 | 125234853 | 125241343 | Human | 1403 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1602337 | MMP23A | matrix metallopeptidase 23A (pseudogene) | This locus represents the partially duplicated copy of the MMP23B gene, and therefore considered a pseudogene. This pseudogene is part of a duplicated region of chromosome 1p36.3. It belongs to the more centromeric copy of the duplicated region. [provided by RefSeq, Jul 2008] | 1 | 1699939 | 1701808 | Human | 6 | old_gene_symbol | gene, pseudo, PROVISIONAL [RefSeq] |
| 1344169 | MMP23B | matrix metallopeptidase 23B | This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryon ic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the more telomeric copy of the duplicated region. [provided by RefSeq, Jul 2008] | 1 | 1632173 | 1634654 | Human | 209 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1319839 | BNIPL | BCL2 interacting protein like | The protein encoded by this gene interacts with several other proteins, such as BCL2, ARHGAP1, MIF and GFER. It may function as a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] | 1 | 151036586 | 151047720 | Human | 50 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1350471 | CD74 | CD74 molecule | The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF eight:700;'>MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] | 5 | 150401639 | 150412910 | Human | 377 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1345070 | NOM1 | nucleolar protein with MIF4G domain 1 | Proteins that contain MIF4G (middle of eIF4G (MIM 600495)) and/or MA3 domains, such as NOM1, function in protein translation. These domains include binding sites for members of the EIF4A family of ATP-dependent DEAD box RNA helicases (see EIF4A1; MIM 602641) (Si mmons et al., 2005 [PubMed 15715967]).[supplied by OMIM, Mar 2008] | 7 | 156949712 | 156973176 | Human | 49 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
