| 736262 | MBP | myelin basic protein | The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and th e immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008] | 18 | 76978833 | 77133708 | Human | 342 | symbol , COSMIC , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 38605935 | MBP-AS1 | MBP antisense RNA 1 | | 18 | 76980429 | 76984152 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna, MODEL [RefSeq] |
| 616940551 | MBP-AS2 | MBP antisense RNA 2 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna |
| 735547 | MBL2 | mannose binding lectin 2 | This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes and binds to mannose and N-acetylglucosamine on many microorganisms, inc luding bacteria, yeast, and viruses including influenza virus, HIV and SARS-CoV. This binding activates the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jun 2020] | 10 | 52765380 | 52772784 | Human | 386 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 737332 | PRG2 | proteoglycan 2, pro eosinophil major basic protein | The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plas ma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014] | 11 | 57386780 | 57390650 | Human | 102 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 735808 | ENO1 | enolase 1 | This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011] | 1 | 8861000 | 8878686 | Human | 456 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 736425 | HIVEP1 | HIVEP zinc finger 1 | This gene encodes a transcription factor belonging to the ZAS family, members of which are large proteins that contain a ZAS domain - a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specificall y to the DNA sequence motif, GGGACTTTCC, found in the enhancer elements of several viral promoters, including human immunodeficiency virus (HIV), and to related sequences found in the enhancer elements of a number of cellular promoters. This protein binds to this sequence motif, suggesting a role in the transcriptional regulation of both viral and cellular genes. [provided by RefSeq, Oct 2011] | 6 | 12007693 | 12212048 | Human | 150 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 734342 | HIVEP2 | HIVEP zinc finger 2 | This gene encodes a member of a family of closely related, large, zinc finger-containing transcription factors. The encoded protein regulates transcription by binding to regulatory regions of various cellular and viral genes that maybe involved in growth, development and metastasis. The protein cont ains the ZAS domain comprised of two widely separated regions of zinc finger motifs, a stretch of highly acidic amino acids and a serine/threonine-rich sequence. [provided by RefSeq, Nov 2012] | 6 | 142751469 | 142945733 | Human | 247 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 16567467 | AC018529.1 | novel transcript, antisense to MBP | | | | | Human | | name | gene, lncrna |
| 16568514 | AC018529.2 | novel transcript, antisense to MBP | | | | | Human | | name | gene, lncrna |
| 16564315 | AC093330.1 | novel transcript, antisense to MBP | | | | | Human | | name | gene, lncrna |
| 16572757 | AC093330.3 | novel transcript, antisense to MBP | | | | | Human | | name | gene, lncrna |
| 1350228 | TRAPPC2 | trafficking protein particle complex subunit 2 | The protein encoded by this gene is thought to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind c-myc promoter-binding protein 1 and block its transcriptional repression capability. Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseudogenes are found on chromosomes 8 and Y. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010] | X | 13712245 | 13734620 | Human | 208 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1351912 | TRAPPC2B | trafficking protein particle complex subunit 2B | Enables transcription corepressor binding activity; transcription regulator inhibitor activity; and transmembrane transporter binding activity. Involved in positive regulation of gene expression and skeletal system development. Located in endoplasmic reticulum; nucleus; and perinuclear region of cyt oplasm. Part of TRAPP complex. [provided by Alliance of Genome Resources, Jul 2025] | 19 | 57363551 | 57365405 | Human | 52 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1350845 | ZNF547 | zinc finger protein 547 | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 19 | 57363551 | 57379565 | Human | 36 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1349728 | EFEMP2 | EGF-like fibulin extracellular matrix protein 2 | A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. The protein encoded by this gene contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is necessary for elastic fiber formation and connective tissue development. Defects in this gene are cause of an autosomal recessive cutis laxa syndrome. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jan 2011] | 11 | 65866441 | 65872800 | Human | 413 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1320501 | PRG3 | proteoglycan 3, pro eosinophil major basic protein 2 | An extracellular matrix structural constituent conferring compression resistance. Involved in several processes, including granulocyte activation; histamine biosynthetic process; and regulation of gene expression. Located in collagen-containing extracellular matrix. [provided by Alliance of Genome R esources, Apr 2025] | 11 | 57376769 | 57381150 | Human | 39 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1605408 | CKAP5 | cytoskeleton associated protein 5 | This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; i t protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] | 11 | 46743048 | 46846280 | Human | 158 | description | gene, protein-coding, REVIEWED [RefSeq] |
