PRG2 (proteoglycan 2, pro eosinophil major basic protein) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: PRG2 (proteoglycan 2, pro eosinophil major basic protein) Homo sapiens
Analyze
Symbol: PRG2
Name: proteoglycan 2, pro eosinophil major basic protein
RGD ID: 737332
HGNC Page HGNC:9362
Description: An extracellular matrix structural constituent conferring compression resistance. Predicted to be involved in defense response to bacterium and immune response. Predicted to act upstream of or within defense response to nematode and regulation of cytokine production. Located in collagen-containing extracellular matrix and extracellular exosome. Biomarker of Chagas disease; asthma; and peritoneum cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: BMPG; bone marrow proteoglycan; bone-marrow proteoglycan; eosinophil granule major basic protein; eosinophil major basic protein; MBP; MBP1; MGC14537; natural killer cell activator; proMBP; proteoglycan 2 preproprotein; proteoglycan 2, bone marrow; proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: MBP is an alias on both PRG2 (Gene ID: 5553, "major basic protein") and MBL2 (Gene ID: 4153, "mannose-binding protein C"). MBP is also the official symbol on GeneID: 4155 (myelin basic protein). [01 Jun 2018]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381157,386,780 - 57,390,650 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1157,386,780 - 57,390,650 (-)EnsemblGRCh38hg38GRCh38
GRCh371157,154,253 - 57,158,123 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361156,911,410 - 56,914,706 (-)NCBINCBI36Build 36hg18NCBI36
Build 341156,911,410 - 56,914,706NCBI
Celera1154,511,420 - 54,514,715 (-)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1153,504,113 - 53,507,408 (-)NCBIHuRef
CHM1_11157,020,853 - 57,024,149 (-)NCBICHM1_1
T2T-CHM13v2.01157,336,805 - 57,340,674 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Maternal Pre-Pregnancy Obesity Is Associated with Altered Placental Transcriptome. Altmäe S, etal., PLoS One. 2017 Jan 26;12(1):e0169223. doi: 10.1371/journal.pone.0169223. eCollection 2017.
2. Eosinophils are important for protection, immunoregulation and pathology during infection with nematode microfilariae. Cadman ET, etal., PLoS Pathog. 2014 Mar 13;10(3):e1003988. doi: 10.1371/journal.ppat.1003988. eCollection 2014 Mar.
3. Eosinophil major basic protein-1 does not contribute to allergen-induced airway pathologies in mouse models of asthma. Denzler KL, etal., J Immunol. 2000 Nov 15;165(10):5509-17.
4. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
5. Alterations in Placental Gene Expression of Pregnant Women with Chronic Chagas Disease. Juiz NA, etal., Am J Pathol. 2018 Jun;188(6):1345-1353. doi: 10.1016/j.ajpath.2018.02.011. Epub 2018 Mar 12.
6. Eosinophil degranulation is more important than eosinophilia in identifying asthma in chronic cough. Kim CK, etal., J Asthma. 2011 Dec;48(10):994-1000. doi: 10.3109/02770903.2011.623335. Epub 2011 Oct 24.
7. [Expression of eosinophil major basic protein mRNA in bronchial asthma]. Li SH, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2006 Sep;26(9):1330-3.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Interferon gene expression in sputum cells correlates with the Asthma Index Score during virus-induced exacerbations. Schwantes EA, etal., Clin Exp Allergy. 2014 Jun;44(6):813-21. doi: 10.1111/cea.12269.
11. Peritoneal carcinomatosis of colorectal cancer is characterized by structural and functional reorganization of the tumor microenvironment inducing senescence and proliferation arrest in cancer cells. Seebauer CT, etal., Oncoimmunology. 2016 Oct 14;5(12):e1242543. doi: 10.1080/2162402X.2016.1242543. eCollection 2016.
Additional References at PubMed
PMID:319906   PMID:1565101   PMID:2323577   PMID:2501794   PMID:2584934   PMID:3171483   PMID:3199069   PMID:3410852   PMID:3422083   PMID:7508748   PMID:7524900   PMID:7526035  
PMID:7531438   PMID:7539791   PMID:7685339   PMID:7727786   PMID:8137941   PMID:8507662   PMID:8547309   PMID:9736715   PMID:9748166   PMID:10357815   PMID:10491647   PMID:10698680  
PMID:10913121   PMID:11170744   PMID:11222751   PMID:11278835   PMID:11319227   PMID:11445557   PMID:11546794   PMID:12149249   PMID:12176337   PMID:12202480   PMID:12370176   PMID:12393403  
PMID:12421832   PMID:12477932   PMID:12534990   PMID:14500673   PMID:14988014   PMID:15489334   PMID:15647258   PMID:16169070   PMID:16344560   PMID:16940047   PMID:17082653   PMID:17136616  
PMID:17223728   PMID:17308074   PMID:18029348   PMID:18476621   PMID:18720885   PMID:18852884   PMID:19014520   PMID:19039208   PMID:19398958   PMID:19626619   PMID:20237496   PMID:20849415  
PMID:20977431   PMID:22412388   PMID:23033876   PMID:23376485   PMID:23533145   PMID:24112102   PMID:24814827   PMID:25037231   PMID:25266917   PMID:25728769   PMID:26186194   PMID:28344315  
PMID:28514442   PMID:29936783   PMID:30021884   PMID:30463901   PMID:31595373   PMID:33689807   PMID:33961781   PMID:33982062   PMID:36607699   PMID:37278449  


Genomics

Comparative Map Data
PRG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381157,386,780 - 57,390,650 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1157,386,780 - 57,390,650 (-)EnsemblGRCh38hg38GRCh38
GRCh371157,154,253 - 57,158,123 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361156,911,410 - 56,914,706 (-)NCBINCBI36Build 36hg18NCBI36
Build 341156,911,410 - 56,914,706NCBI
Celera1154,511,420 - 54,514,715 (-)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1153,504,113 - 53,507,408 (-)NCBIHuRef
CHM1_11157,020,853 - 57,024,149 (-)NCBICHM1_1
T2T-CHM13v2.01157,336,805 - 57,340,674 (-)NCBIT2T-CHM13v2.0
Prg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39284,810,805 - 84,813,977 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl284,810,805 - 84,813,976 (+)EnsemblGRCm39 Ensembl
GRCm38284,980,461 - 84,983,632 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl284,980,461 - 84,983,632 (+)EnsemblGRCm38mm10GRCm38
MGSCv37284,820,618 - 84,823,789 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36284,781,300 - 84,784,471 (+)NCBIMGSCv36mm8
Celera286,579,143 - 86,582,324 (+)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.45NCBI
Prg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8390,469,192 - 90,472,759 (+)NCBIGRCr8
mRatBN7.2370,062,535 - 70,066,102 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl370,062,535 - 70,066,101 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx373,444,448 - 73,448,007 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0382,043,123 - 82,046,682 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0379,801,564 - 79,805,137 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0372,385,678 - 72,389,245 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl372,385,666 - 72,389,276 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0378,895,715 - 78,899,282 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4368,209,731 - 68,213,293 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1368,106,102 - 68,109,669 (+)NCBI
Celera369,413,529 - 69,417,096 (+)NCBICelera
Cytogenetic Map3q24NCBI
PRG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2958,543,286 - 58,547,177 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11159,560,838 - 59,564,163 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01152,628,289 - 52,631,634 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13160,118,686 - 160,122,041 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3160,118,111 - 160,122,002 (-)Ensemblpanpan1.1panPan2
LOC102156778
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11838,753,269 - 38,760,730 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1838,303,196 - 38,306,317 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01839,438,926 - 39,442,046 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11839,021,552 - 39,024,671 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01838,595,057 - 38,598,175 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01839,225,795 - 39,228,916 (+)NCBIUU_Cfam_GSD_1.0
Prg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494714,987,025 - 14,989,758 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365815,100,623 - 5,102,857 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365815,101,041 - 5,103,175 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1115,850,181 - 15,854,511 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl115,850,913 - 15,854,517 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038113,195,782 - 113,199,106 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in PRG2
12 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q12.1(chr11:57372226-57936167)x3 copy number gain See cases [RCV000051908] Chr11:57372226..57936167 [GRCh38]
Chr11:57139699..57703639 [GRCh37]
Chr11:56896275..57460215 [NCBI36]
Chr11:11q12.1
uncertain significance
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3
pathogenic
GRCh38/hg38 11q11-12.1(chr11:55316535-57539457)x3 copy number gain See cases [RCV000141200] Chr11:55316535..57539457 [GRCh38]
Chr11:55084011..57306930 [GRCh37]
Chr11:54840587..57063506 [NCBI36]
Chr11:11q11-12.1
uncertain significance
GRCh38/hg38 11q11-12.1(chr11:55319519-58998777)x3 copy number gain See cases [RCV000142757] Chr11:55319519..58998777 [GRCh38]
Chr11:55086995..58766250 [GRCh37]
Chr11:54843571..58522826 [NCBI36]
Chr11:11q11-12.1
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p11.12-q12.1(chr11:49313405-59008426)x3 copy number gain not provided [RCV000683370] Chr11:49313405..59008426 [GRCh37]
Chr11:11p11.12-q12.1
uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q12.1(chr11:57147016-57667222)x3 copy number gain not provided [RCV000750056] Chr11:57147016..57667222 [GRCh37]
Chr11:11q12.1
benign
NM_002728.6(PRG2):c.168A>G (p.Glu56=) single nucleotide variant not provided [RCV000972286] Chr11:57389208 [GRCh38]
Chr11:57156681 [GRCh37]
Chr11:11q12.1
benign
Single allele duplication not provided [RCV000844966] Chr11:55033164..57518726 [GRCh37]
Chr11:11q11-12.1
not provided
GRCh37/hg19 11q12.1(chr11:56637024-57361915)x3 copy number gain not provided [RCV002473570] Chr11:56637024..57361915 [GRCh37]
Chr11:11q12.1
uncertain significance
GRCh37/hg19 11q12.1(chr11:57037091-57453575)x3 copy number gain not provided [RCV001829225] Chr11:57037091..57453575 [GRCh37]
Chr11:11q12.1
uncertain significance
GRCh37/hg19 11q12.1(chr11:57112299-57871866)x3 copy number gain not provided [RCV001825196] Chr11:57112299..57871866 [GRCh37]
Chr11:11q12.1
not provided
GRCh37/hg19 11p11.2-q12.2(chr11:51581311-54891247)x3 copy number gain See cases [RCV002286338] Chr11:51581311..54891247 [GRCh37]
Chr11:11p11.2-q12.2
pathogenic
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25
pathogenic
NM_002728.6(PRG2):c.191G>A (p.Ser64Asn) single nucleotide variant Inborn genetic diseases [RCV002773028] Chr11:57389185 [GRCh38]
Chr11:57156658 [GRCh37]
Chr11:11q12.1
uncertain significance
NM_002728.6(PRG2):c.626G>C (p.Arg209Pro) single nucleotide variant Inborn genetic diseases [RCV002993252] Chr11:57387518 [GRCh38]
Chr11:57154991 [GRCh37]
Chr11:11q12.1
uncertain significance
NM_002728.6(PRG2):c.487A>T (p.Ile163Phe) single nucleotide variant Inborn genetic diseases [RCV002689231] Chr11:57388588 [GRCh38]
Chr11:57156061 [GRCh37]
Chr11:11q12.1
uncertain significance
NM_002728.6(PRG2):c.412A>T (p.Asn138Tyr) single nucleotide variant Inborn genetic diseases [RCV002821387] Chr11:57388663 [GRCh38]
Chr11:57156136 [GRCh37]
Chr11:11q12.1
uncertain significance
NM_002728.6(PRG2):c.104T>A (p.Leu35Gln) single nucleotide variant Inborn genetic diseases [RCV002662183] Chr11:57389272 [GRCh38]
Chr11:57156745 [GRCh37]
Chr11:11q12.1
uncertain significance
NM_002728.6(PRG2):c.118G>A (p.Glu40Lys) single nucleotide variant Inborn genetic diseases [RCV002666060] Chr11:57389258 [GRCh38]
Chr11:57156731 [GRCh37]
Chr11:11q12.1
uncertain significance
NM_002728.6(PRG2):c.323G>A (p.Arg108His) single nucleotide variant Inborn genetic diseases [RCV002941503] Chr11:57389053 [GRCh38]
Chr11:57156526 [GRCh37]
Chr11:11q12.1
uncertain significance
NM_002728.6(PRG2):c.283A>C (p.Thr95Pro) single nucleotide variant Inborn genetic diseases [RCV002714191] Chr11:57389093 [GRCh38]
Chr11:57156566 [GRCh37]
Chr11:11q12.1
uncertain significance
NM_002728.6(PRG2):c.148C>A (p.Pro50Thr) single nucleotide variant Inborn genetic diseases [RCV002831033] Chr11:57389228 [GRCh38]
Chr11:57156701 [GRCh37]
Chr11:11q12.1
uncertain significance
NM_002728.6(PRG2):c.559G>T (p.Ala187Ser) single nucleotide variant Inborn genetic diseases [RCV002679820] Chr11:57387805 [GRCh38]
Chr11:57155278 [GRCh37]
Chr11:11q12.1
uncertain significance
NM_002728.6(PRG2):c.515T>A (p.Phe172Tyr) single nucleotide variant Inborn genetic diseases [RCV003263671] Chr11:57387849 [GRCh38]
Chr11:57155322 [GRCh37]
Chr11:11q12.1
uncertain significance
NM_002728.6(PRG2):c.645A>T (p.Arg215Ser) single nucleotide variant Inborn genetic diseases [RCV003381149] Chr11:57387499 [GRCh38]
Chr11:57154972 [GRCh37]
Chr11:11q12.1
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1343
Count of miRNA genes:455
Interacting mature miRNAs:476
Transcripts:ENST00000311862, ENST00000525955, ENST00000530105, ENST00000533605
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D11S4608  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371157,154,854 - 57,154,962UniSTSGRCh37
Build 361156,911,430 - 56,911,538RGDNCBI36
Celera1154,511,440 - 54,511,548RGD
Cytogenetic Map11q12UniSTS
HuRef1153,504,133 - 53,504,241UniSTS
GeneMap99-G3 RH Map112423.0UniSTS
D11S3454  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371157,154,332 - 57,154,565UniSTSGRCh37
Build 361156,910,908 - 56,911,141RGDNCBI36
Celera1154,510,918 - 54,511,151RGD
Cytogenetic Map11q12UniSTS
HuRef1153,503,611 - 53,503,844UniSTS
A005W41  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371157,154,842 - 57,154,981UniSTSGRCh37
Build 361156,911,418 - 56,911,557RGDNCBI36
Celera1154,511,428 - 54,511,567RGD
Cytogenetic Map11q12UniSTS
HuRef1153,504,121 - 53,504,260UniSTS
GeneMap99-GB4 RH Map11214.67UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High 14 16 1 1
Medium 22 336 74 29 403 25 654 20 38 1 5 141 4 273 345 2
Low 1411 1751 1146 445 871 305 2873 1139 904 45 818 1083 142 914 1917
Below cutoff 830 854 419 107 508 91 659 987 2236 183 442 200 24 1 17 520

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001243245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001302926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001302927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK312195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP000781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU135652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ445845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX395670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX397850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX454677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB997424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR450311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA841825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ846874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC007226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M34462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M35670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M36805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X65787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y00809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z26248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000311862   ⟹   ENSP00000312134
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1157,386,780 - 57,390,650 (-)Ensembl
RefSeq Acc Id: ENST00000525955   ⟹   ENSP00000433016
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1157,386,943 - 57,390,636 (-)Ensembl
RefSeq Acc Id: ENST00000530105
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1157,387,443 - 57,390,629 (-)Ensembl
RefSeq Acc Id: ENST00000533605   ⟹   ENSP00000433231
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1157,386,815 - 57,390,637 (-)Ensembl
RefSeq Acc Id: NM_001243245   ⟹   NP_001230174
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381157,386,780 - 57,390,650 (-)NCBI
GRCh371157,154,834 - 57,171,420 (-)NCBI
HuRef1153,504,113 - 53,507,408 (-)NCBI
CHM1_11157,020,279 - 57,024,149 (-)NCBI
T2T-CHM13v2.01157,336,805 - 57,340,674 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001302926   ⟹   NP_001289855
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381157,386,780 - 57,390,650 (-)NCBI
CHM1_11157,020,279 - 57,024,149 (-)NCBI
T2T-CHM13v2.01157,336,805 - 57,340,674 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001302927   ⟹   NP_001289856
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381157,386,780 - 57,390,650 (-)NCBI
CHM1_11157,020,279 - 57,024,149 (-)NCBI
T2T-CHM13v2.01157,336,805 - 57,340,674 (-)NCBI
Sequence:
RefSeq Acc Id: NM_002728   ⟹   NP_002719
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381157,386,780 - 57,390,650 (-)NCBI
GRCh371157,154,834 - 57,171,420 (-)NCBI
Build 361156,911,410 - 56,914,706 (-)NCBI Archive
HuRef1153,504,113 - 53,507,408 (-)ENTREZGENE
CHM1_11157,020,279 - 57,024,149 (-)NCBI
T2T-CHM13v2.01157,336,805 - 57,340,674 (-)NCBI
Sequence:
RefSeq Acc Id: NP_002719   ⟸   NM_002728
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q14227 (UniProtKB/Swiss-Prot),   P81448 (UniProtKB/Swiss-Prot),   B2R5I1 (UniProtKB/Swiss-Prot),   A6XMW0 (UniProtKB/Swiss-Prot),   Q6ICT2 (UniProtKB/Swiss-Prot),   P13727 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001230174   ⟸   NM_001243245
- Peptide Label: isoform 2 preproprotein
- UniProtKB: P13727 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001289855   ⟸   NM_001302926
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q14227 (UniProtKB/Swiss-Prot),   P81448 (UniProtKB/Swiss-Prot),   B2R5I1 (UniProtKB/Swiss-Prot),   A6XMW0 (UniProtKB/Swiss-Prot),   Q6ICT2 (UniProtKB/Swiss-Prot),   P13727 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001289856   ⟸   NM_001302927
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q14227 (UniProtKB/Swiss-Prot),   P81448 (UniProtKB/Swiss-Prot),   B2R5I1 (UniProtKB/Swiss-Prot),   A6XMW0 (UniProtKB/Swiss-Prot),   Q6ICT2 (UniProtKB/Swiss-Prot),   P13727 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000433231   ⟸   ENST00000533605
RefSeq Acc Id: ENSP00000312134   ⟸   ENST00000311862
RefSeq Acc Id: ENSP00000433016   ⟸   ENST00000525955
Protein Domains
C-type lectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13727-F1-model_v2 AlphaFold P13727 1-222 view protein structure

Promoters
RGD ID:6789410
Promoter ID:HG_KWN:12919
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:NB4
Transcripts:ENST00000311862,   UC001NJW.1,   UC001NJX.1,   UC001NJY.1,   UC001NKA.1,   UC001NKB.1,   UC001NKD.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361156,914,411 - 56,914,911 (-)MPROMDB
RGD ID:7220319
Promoter ID:EPDNEW_H15905
Type:multiple initiation site
Name:PRG2_1
Description:proteoglycan 2, pro eosinophil major basic protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381157,390,650 - 57,390,710EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9362 AgrOrtholog
COSMIC PRG2 COSMIC
Ensembl Genes ENSG00000186652 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000311862 ENTREZGENE
  ENST00000311862.10 UniProtKB/Swiss-Prot
  ENST00000525955 ENTREZGENE
  ENST00000525955.1 UniProtKB/Swiss-Prot
  ENST00000533605 ENTREZGENE
  ENST00000533605.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot
GTEx ENSG00000186652 GTEx
HGNC ID HGNC:9362 ENTREZGENE
Human Proteome Map PRG2 Human Proteome Map
InterPro C-type_lectin-like UniProtKB/Swiss-Prot
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot
  C-type_lectin_CS UniProtKB/Swiss-Prot
  CTDL_fold UniProtKB/Swiss-Prot
  EMBP_CTLD UniProtKB/Swiss-Prot
  Eosinophil_major_basic UniProtKB/Swiss-Prot
KEGG Report hsa:5553 UniProtKB/Swiss-Prot
NCBI Gene 5553 ENTREZGENE
OMIM 605601 OMIM
PANTHER ACCESSORY GLAND PROTEIN ACP29AB-RELATED UniProtKB/Swiss-Prot
  MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED UniProtKB/Swiss-Prot
Pfam Lectin_C UniProtKB/Swiss-Prot
PharmGKB PA33734 PharmGKB
PRINTS EMAJORBASICP UniProtKB/Swiss-Prot
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot
SMART CLECT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot
UniProt A6XMW0 ENTREZGENE
  B2R5I1 ENTREZGENE
  P13727 ENTREZGENE
  P81448 ENTREZGENE
  PRG2_HUMAN UniProtKB/Swiss-Prot
  Q14227 ENTREZGENE
  Q6ICT2 ENTREZGENE
UniProt Secondary A6XMW0 UniProtKB/Swiss-Prot
  B2R5I1 UniProtKB/Swiss-Prot
  P81448 UniProtKB/Swiss-Prot
  Q14227 UniProtKB/Swiss-Prot
  Q6ICT2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-21 PRG2  proteoglycan 2, pro eosinophil major basic protein    proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)  Symbol and/or name change 5135510 APPROVED