| 731331 | MAF | MAF bZIP transcription factor | The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the reg ulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] | 16 | 79202622 | 79600737 | Human | 367 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 732545 | MAFB | MAF bZIP transcription factor B | The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns. [provided by RefSeq, Jul 2008] | 20 | 40685848 | 40689236 | Human | 470 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1319919 | MAFF | MAF bZIP transcription factor F | The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to en hance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2009] | 22 | 38201994 | 38216511 | Human | 380 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 736902 | GC | GC vitamin D binding protein | The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively splice d transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011] | 4 | 71741693 | 71805520 | Human | 254 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1313083 | NRL | neural retina leucine zipper | This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function. Mutations in this gene have been associate d with retinitis pigmentosa and retinal degenerative diseases. [provided by RefSeq, Jul 2008] | 14 | 24078662 | 24114949 | Human | 229 | old_gene_name , description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 9831044 | MAFTRR | MAF transcriptional regulator RNA | INTERACTS WITH 2-hydroxypropanoic acid; rac-lactic acid | 16 | 79721312 | 79770532 | Human | 2 | symbol , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 1603294 | CMIP | c-Maf inducing protein | This gene encodes a c-Maf inducing protein that plays a role in T-cell signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] | 16 | 81444808 | 81711762 | Human | 114 | old_gene_name , name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1604438 | MAFA | MAF bZIP transcription factor A | MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene (INS; MIM 176730) (Olbrot et al., 2002 [PubMed 12011435]).[supplied by OMIM, Mar 2008] | 8 | 143428064 | 143430732 | Human | 152 | symbol , old_gene_name , COSMIC , name , description , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1352039 | MAFG | MAF bZIP transcription factor G | Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010] | 17 | 81918270 | 81931244 | Human | 235 | symbol , old_gene_name , COSMIC , name , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1350091 | MAFK | MAF bZIP transcription factor K | The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are als o present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM, Nov 2008] | 7 | 1530702 | 1543043 | Human | 194 | symbol , old_gene_name , COSMIC , name , description , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1601952 | MAF1 | MAF1 negative regulator of RNA polymerase III | This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the c ellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression. [provided by RefSeq, Jul 2008] | 8 | 144104461 | 144107611 | Human | 107 | symbol , old_gene_name , COSMIC , name , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 2303835 | MAFIP | MAFF interacting protein | This gene was originally thought to be a protein coding gene. However, the encoded protein sequence is highly similar to the C-terminal sequence of the tektin-4 protein, and the transcript sequences of this gene are highly similar to the TEKT4 pseudogenes, which are found on chromosomes 4, 21 and Y, respectively. Therefore, this gene is thought to be another pseudogene of the TEKT4 gene (GeneID:150483). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2012] | | | | Human | 17 | symbol , GTEx , old_gene_name , COSMIC , name , Human Proteome Map | gene, pseudo, VALIDATED [RefSeq] |
| 38604190 | MAF1P1 | MAF1 pseudogene 1 | | 3 | 133490635 | 133491760 | Human | | symbol , GTEx , old_gene_name , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 407574770 | MAFA-AS1 | MAFA antisense RNA 1 | INTERACTS WITH 2-hydroxypropanoic acid; dimethylselenide; methylisothiazolinone | 8 | 143408193 | 143419150 | Human | 5 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 155882950 | MAFG-AS1 | MAFG antisense RNA 1 | | 17 | 81922899 | 81924511 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 16563968 | MAFG-AS1 | MAFG antisense RNA 1 | | | | | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, lncrna |
| 737284 | KLRG1 | killer cell lectin like receptor G1 | Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) fam ily, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. [provided by RefSeq, Jun 2016] | 12 | 8950044 | 9215570 | Human | 83 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 734419 | FBXO32 | F-box protein 32 | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependen t ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011] | 8 | 123497889 | 123541206 | Human | 267 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 5684558 | MILIP | MYC inducible lncRNA inactivating p53 | INTERACTS WITH (+)-catechin; 5-aza-2'-deoxycytidine; acrylamide | 17 | 81927829 | 81930753 | Human | 13 | old_gene_name , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 5132676 | TEKT4P2 | tektin 4 pseudogene 2 | INTERACTS WITH 2-hydroxypropanoic acid; aflatoxin B1; all-trans-retinoic acid | 21 | 9068356 | 9129761 | Human | 17 | old_gene_name | gene, pseudo, VALIDATED [RefSeq] |
| 1315744 | ASMTL | acetylserotonin O-methyltransferase like | The protein encoded by this gene has an N-terminus that is similar to the multicopy associated filamentation (maf) protein of Bacillus subtilis and to orfE of Escherichia coli, while the C-terminus is similar to N-acetylserotonin O-methyltransferase. This gene i s located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] | X | 1403139 | 1453756 | Human | 80 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1315744 | ASMTL | acetylserotonin O-methyltransferase like | The protein encoded by this gene has an N-terminus that is similar to the multicopy associated filamentation (maf) protein of Bacillus subtilis and to orfE of Escherichia coli, while the C-terminus is similar to N-acetylserotonin O-methyltransferase. This gene i s located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] | Y | 1403139 | 1453756 | Human | 80 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1315457 | BACH1 | BACH transcriptional regulator 1 | This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These B TB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009] | 21 | 29298922 | 29361894 | Human | 244 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 38636459 | LOC105379554 | maFF-interacting protein | INVOLVED IN cilium movement involved in cell motility (inferred); DNA-templated transcription (inferred); FOUND IN cilium (inferred); cytoplasm (inferred); nucleolus (inferred) | | | | Human | 6 | name | gene, protein-coding, MODEL [RefSeq] |
| 329832408 | LOC128966690 | maFF-interacting protein | | | | | Human | | name | gene, pseudo, MODEL [RefSeq] |
| 16552121 | AC022296.2 | pseudogene similar to part of MAF1 | | | | | Human | | name | gene, processed_pseudogene |
| 16568486 | AC134878.2 | MAFF interacting protein (pseudogene) | | | | | Human | | name | gene, transcribed_unprocessed_pseudogene |
| 1604510 | CEP112 | centrosomal protein 112 | This gene encodes a coiled-coil domain containing protein that belongs to the cell division control protein 42 effector protein family. In neurons, it localizes to the cytoplasm of dendrites and is also enriched in the nucleus where it interacts with the RNA polymerase III transcriptional repressor Maf1 to regulate gamma-aminobutyric acid A receptor surface expression. In addition, the protein has been identified as a component of the human centrosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] | 17 | 65635537 | 66192133 | Human | 88 | description | gene, protein-coding, REVIEWED [RefSeq] |
