Il18 Gene Search Result

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6 records found for search term Il18

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
730894	IL18	interleukin 18	The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable ... (more) of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm. In humans, IL-18 gene is located on chromosome 11. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2020]	11	112143260	112164094	Human	1129	symbol , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
1348622	IL18BP	interleukin 18 binding protein	The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18 ... (more) le='font-weight:700;'>IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]	11	71998909	72008200	Human	117	symbol , COSMIC , description , Human Proteome Map , old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]
1318449	IL18R1	interleukin 18 receptor 1	The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-a ... (more) lpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]	2	102355796	102398776	Human	155	symbol , old_gene_name , COSMIC , description , Human Proteome Map , old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]
1315691	IL18RAP	interleukin 18 receptor accessory protein	The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding ... (more) activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]	2	102418621	102452565	Human	111	symbol , COSMIC , description , Human Proteome Map , old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]
1346334	IL37	interleukin 37	The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18 ... (more) 00;'>IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]	2	112911165	112918882	Human	96	description	gene, protein-coding, REVIEWED [RefSeq]
1353187	IL1RL2	interleukin 1 receptor like 2	The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor f ... (more) amily genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008]	2	102186973	102243086	Human	83	description	gene, protein-coding, REVIEWED [RefSeq]