| 1344972 | BTBD2 | BTB domain containing 2 | The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. [provided by RefSeq, Jul 2008] | 19 | 1985448 | 2015714 | Human | 71 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 16564554 | AC005306.1 | novel transcript, antisense to BTBD2 | | | | | Human | | name | gene, lncrna |
| 1349137 | ABTB1 | ankyrin repeat and BTB domain containing 1 | This gene encodes a protein with an ankyrin repeat region and two BTB/POZ domains, which are thought to be involved in protein-protein interactions. Expression of this gene is activated by the phosphatase and tensin homolog, a tumor suppressor. Alternate splicing results in three transcript variants . [provided by RefSeq, Mar 2010] | 3 | 127672952 | 127680926 | Human | 77 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 733617 | ABTB2 | ankyrin repeat and BTB domain containing 2 | Predicted to enable protein heterodimerization activity. Predicted to act upstream of or within cellular response to toxic substance. [provided by Alliance of Genome Resources, Jul 2025] | 11 | 34150987 | 34358010 | Human | 117 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1320021 | ANKFY1 | ankyrin repeat and FYVE domain containing 1 | This gene encodes a cytoplasmic protein that contains a coiled-coil structure and a BTB/POZ domain at its N-terminus, ankyrin repeats in the middle portion, and a FYVE-finger motif at its C-terminus. This protein belongs to a subgroup of double zinc finger proteins which may be involved in vesicle o r protein transport. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Apr 2012] | 17 | 4163821 | 4263979 | Human | 126 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1315457 | BACH1 | BACH transcriptional regulator 1 | This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These B TB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009] | 21 | 29298922 | 29361894 | Human | 246 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1319503 | BACH2 | BACH transcriptional regulator 2 | Enables sequence-specific double-stranded DNA binding activity. Involved in primary adaptive immune response involving T cells and B cells. Located in cytosol and nucleoplasm. Part of RNA polymerase II transcription regulator complex. Implicated in immunodeficiency 60. [provided by Alliance of Genom e Resources, Jul 2025] | 6 | 89926528 | 90296843 | Human | 166 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1343153 | CCIN | calicin | The protein encoded by this gene is a basic protein of the sperm head cytoskeleton. This protein contains kelch repeats and a BTB/POZ domain and is necessary for normal morphology during sperm differentiation. This gene is intronless. [provided by RefSeq, Jul 2008] | 9 | 36169388 | 36171334 | Human | 46 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1323289 | IBTK | inhibitor of Bruton tyrosine kinase | Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regu lates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014] | 6 | 82169987 | 82247744 | Human | 94 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1347079 | KCTD10 | potassium channel tetramerization domain containing 10 | The protein encoded by this gene binds proliferating cell nuclear antigen (PCNA) and may be involved in DNA synthesis and cell proliferation. In addition, the encoded protein may be a tumor suppressor. Several protein-coding and non-protein coding transcript variants have been found for this gene. [ provided by RefSeq, Dec 2015] | 12 | 109448655 | 109477300 | Human | 100 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1323768 | KCTD9 | potassium channel tetramerization domain containing 9 | Enables cullin family protein binding activity and identical protein binding activity. Predicted to be involved in intracellular signal transduction; protein homooligomerization; and protein ubiquitination. Predicted to act upstream of or within several processes, including NK T cell lineage commitm ent; natural killer cell activation; and response to virus. [provided by Alliance of Genome Resources, Jul 2025] | 8 | 25427847 | 25458433 | Human | 87 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1319250 | LZTR1 | leucine zipper like post translational regulator 1 | This gene encodes a member of the BTB-kelch superfamily. Initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may he lp stabilize the Gogli complex. Deletion of this gene may be associated with DiGeorge syndrome. [provided by RefSeq, Jul 2008] | 22 | 20982297 | 20999032 | Human | 861 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
