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Gene: IBTK (inhibitor of Bruton tyrosine kinase) Homo sapiens
Symbol: IBTK
Name: inhibitor of Bruton tyrosine kinase
Description: Exhibits protein kinase binding activity and protein tyrosine kinase inhibitor activity. Involved in negative regulation of protein phosphorylation and release of sequestered calcium ion into cytosol. Localizes to cytoplasm and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Bruton agammaglobulinemia tyrosine kinase inhibitor; BTBD26; BTK-binding protein; BTKI; inhibitor of Bruton agammaglobulinemia tyrosine kinase; inhibitor of Bruton's tyrosine kinase; inhibitor of Bruton's tyrosine kinase-alpha; inhibitor of Bruton's tyrosine kinase-beta; inhibitor of Bruton's tyrosine kinase-gamma; KIAA1417; MGC142256; MGC142258; RP1-93K22.1
Mus musculus (house mouse) : Ibtk (inhibitor of Bruton agammaglobulinemia tyrosine kinase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ibtk (inhibitor of Bruton tyrosine kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ibtk (inhibitor of Bruton tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : IBTK (inhibitor of Bruton tyrosine kinase)
Canis lupus familiaris (dog) : IBTK (inhibitor of Bruton tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ibtk (inhibitor of Bruton tyrosine kinase)
Sus scrofa (pig) : IBTK (inhibitor of Bruton tyrosine kinase)
Chlorocebus sabaeus (African green monkey) : IBTK (inhibitor of Bruton tyrosine kinase)
Heterocephalus glaber (naked mole-rat) : Ibtk (inhibitor of Bruton tyrosine kinase)
more info ...
Related Pseudogenes: IBTKP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl682,169,986 - 82,247,754 (-)EnsemblGRCh38hg38GRCh38
GRCh38682,169,987 - 82,247,747 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37682,879,956 - 82,957,448 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36682,936,675 - 83,014,167 (-)NCBINCBI36hg18NCBI36
Build 34682,936,674 - 83,014,167NCBI
Celera683,302,847 - 83,380,340 (-)NCBI
Cytogenetic Map6q14.1NCBI
HuRef680,097,712 - 80,175,203 (-)NCBIHuRef
CHM1_1682,977,287 - 83,055,040 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on IBTK
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1323289
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.