| 1310218 | Xrn2 | 5'-3' exoribonuclease 2 | ENCODES a protein that exhibits 5'-3' exonuclease activity (ortholog); 5'-3' RNA exonuclease activity (ortholog); identical protein binding (ortholog); INVOLVED IN hippocampus development; neuron differentiation; retina development in camera-type eye; PARTICIPATES IN 3'-end pre-mRNA processing pathw ay; ribosome biogenesis pathway; RNA polymerase II transcription termination pathway; ASSOCIATED WITH status epilepticus; adenoid cystic carcinoma (ortholog); leiomyosarcoma (ortholog); FOUND IN nucleolus (ortholog); nucleoplasm (ortholog); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; bisphenol A | 3 | 154888558 | 154962519 | Rat | 125 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1320991 | XRN2 | 5'-3' exoribonuclease 2 | This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015] | 20 | 21303331 | 21389825 | Human | 138 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1320992 | Xrn2 | 5'-3' exoribonuclease 2 | Predicted to enable several functions, including RNA exonuclease activity, producing 5'-phosphomonoesters; identical protein binding activity; and transcription termination site sequence-specific DNA binding activity. Involved in RNA metabolic process and spermatogenesis. Predicted to be located in aggresome; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma and lung cancer. Orthologous to human XRN2 (5'-3' exoribonuclease 2). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 146854672 | 146919922 | Mouse | 133 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8959545 | Xrn2 | 5'-3' exoribonuclease 2 | ENCODES a protein that exhibits 5'-3' exonuclease activity (ortholog); 5'-3' RNA exonuclease activity (ortholog); identical protein binding (ortholog); INVOLVED IN hippocampus development (ortholog); neuron differentiation (ortholog); retina development in camera-type eye (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; ribosome biogenesis pathway; RNA polymerase II transcription termination pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); leiomyosarcoma (ortholog); lung cancer (ortholog); FOUND IN nucleolus (ortholog); nucleoplasm (ortholog) | NW_004955415 | 29107060 | 29175374 | Chinchilla | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11980794 | XRN2 | 5'-3' exoribonuclease 2 | ENCODES a protein that exhibits 5'-3' exonuclease activity (inferred); 5'-3' RNA exonuclease activity (inferred); exonuclease activity (inferred); INVOLVED IN hippocampus development (ortholog); neuron differentiation (ortholog); retina development in camera-type eye (ortholog); PARTICIPATES IN 3'-e nd pre-mRNA processing pathway; ribosome biogenesis pathway; RNA polymerase II transcription termination pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); leiomyosarcoma (ortholog); lung cancer (ortholog); FOUND IN nucleolus (inferred); nucleoplasm (inferred); nucleus (inferred) | 20 | 21260871 | 21347430 | Bonobo | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12301324 | XRN2 | 5'-3' exoribonuclease 2 | ENCODES a protein that exhibits 5'-3' exonuclease activity (inferred); 5'-3' RNA exonuclease activity (inferred); exonuclease activity (inferred); INVOLVED IN hippocampus development (ortholog); neuron differentiation (ortholog); retina development in camera-type eye (ortholog); PARTICIPATES IN 3'-e nd pre-mRNA processing pathway; ribosome biogenesis pathway; RNA polymerase II transcription termination pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); leiomyosarcoma (ortholog); lung cancer (ortholog); FOUND IN nucleolus (inferred); nucleoplasm (inferred); nucleus (inferred) | 24 | 2042521 | 2128942 | Dog | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12517425 | Xrn2 | 5'-3' exoribonuclease 2 | ENCODES a protein that exhibits 5'-3' exonuclease activity (inferred); 5'-3' RNA exonuclease activity (inferred); exonuclease activity (inferred); INVOLVED IN hippocampus development (ortholog); neuron differentiation (ortholog); retina development in camera-type eye (ortholog); PARTICIPATES IN 3'-e nd pre-mRNA processing pathway; ribosome biogenesis pathway; RNA polymerase II transcription termination pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); leiomyosarcoma (ortholog); lung cancer (ortholog); FOUND IN nucleolus (inferred); nucleoplasm (inferred); nucleus (inferred) | NW_004936620 | 4069956 | 4145212 | Squirrel | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18930847 | Xrn2 | 5'-3' exoribonuclease 2 | ENCODES a protein that exhibits 5'-3' exonuclease activity (ortholog); identical protein binding (ortholog); transcription termination site sequence-specific DNA binding (ortholog); INVOLVED IN hippocampus development (ortholog); neuron differentiation (ortholog); retina development in camera-type e ye (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; ribosome biogenesis pathway; RNA polymerase II transcription termination pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); leiomyosarcoma (ortholog); lung cancer (ortholog); FOUND IN nucleolus (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155234344 | xrn2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18732290 | XRN2 | 5'-3' exoribonuclease 2 | ENCODES a protein that exhibits 5'-3' exonuclease activity (inferred); 5'-3' RNA exonuclease activity (inferred); exonuclease activity (inferred); INVOLVED IN hippocampus development (ortholog); neuron differentiation (ortholog); retina development in camera-type eye (ortholog); PARTICIPATES IN 3'-e nd pre-mRNA processing pathway; ribosome biogenesis pathway; RNA polymerase II transcription termination pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); leiomyosarcoma (ortholog); lung cancer (ortholog); FOUND IN nucleolus (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14004874 | XRN2 | 5'-3' exoribonuclease 2 | ENCODES a protein that exhibits 5'-3' exonuclease activity (inferred); 5'-3' RNA exonuclease activity (inferred); exonuclease activity (inferred); INVOLVED IN hippocampus development (ortholog); neuron differentiation (ortholog); retina development in camera-type eye (ortholog); PARTICIPATES IN 3'-e nd pre-mRNA processing pathway; ribosome biogenesis pathway; RNA polymerase II transcription termination pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); leiomyosarcoma (ortholog); lung cancer (ortholog); FOUND IN nucleolus (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Pig | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625834434 | Xrn2 | 5'-3' exoribonuclease 2 | ENCODES a protein that exhibits 5'-3' exonuclease activity (ortholog); 5'-3' RNA exonuclease activity (ortholog); identical protein binding (ortholog); INVOLVED IN hippocampus development (ortholog); neuron differentiation (ortholog); retina development in camera-type eye (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; ribosome biogenesis pathway; RNA polymerase II transcription termination pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); leiomyosarcoma (ortholog); lung cancer (ortholog); FOUND IN nucleolus (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155234343 | xrn2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155256464 | xrn2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16567565 | AL117332.1 | novel transcript, antisense to XRN2 | | | | | Human | | name | gene, lncrna |