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Gene: XRN2 (5'-3' exoribonuclease 2) Homo sapiens
Symbol: XRN2
Name: 5'-3' exoribonuclease 2
Description: Exhibits 3'-5'-exoribonuclease activity; 5'-3' exonuclease activity; and transcription termination site sequence-specific DNA binding activity. Involved in DNA catabolic process, exonucleolytic and spermatogenesis. Localizes to aggresome; nucleolus; and nucleoplasm. Implicated in adenoid cystic carcinoma and lung cancer. Biomarker of leiomyosarcoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Dhm1-like protein (mouse homolog); DHP protein
Mus musculus (house mouse) : Xrn2 (5'-3' exoribonuclease 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Xrn2 (5'-3' exoribonuclease 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Xrn2 (5'-3' exoribonuclease 2)
Pan paniscus (bonobo/pygmy chimpanzee) : XRN2 (5'-3' exoribonuclease 2)
Canis lupus familiaris (dog) : XRN2 (5'-3' exoribonuclease 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Xrn2 (5'-3' exoribonuclease 2)
Sus scrofa (pig) : XRN2 (5'-3' exoribonuclease 2)
Chlorocebus sabaeus (African green monkey) : XRN2 (5'-3' exoribonuclease 2)
Heterocephalus glaber (naked mole-rat) : Xrn2 (5'-3' exoribonuclease 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2021,303,331 - 21,389,825 (+)EnsemblGRCh38hg38GRCh38
GRCh382021,303,313 - 21,389,825 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372021,283,942 - 21,370,463 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362021,231,942 - 21,318,463 (+)NCBINCBI36hg18NCBI36
Build 342021,231,941 - 21,318,463NCBI
Celera2021,360,521 - 21,444,351 (+)NCBI
Cytogenetic Map20p11.22NCBI
HuRef2021,248,976 - 21,332,731 (+)NCBIHuRef
CHM1_12021,284,695 - 21,370,457 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on XRN2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1320991
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.