| 3976 | Xrcc5 | X-ray repair cross complementing 5 | ENCODES a protein that exhibits double-stranded DNA binding; 5'-deoxyribose-5-phosphate lyase activity (ortholog); ATP hydrolysis activity (ortholog); INVOLVED IN cellular hyperosmotic salinity response; cellular response to fatty acid; cellular response to X-ray; PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH Animal Disease Models (ortholog); basal cell carcinoma (ortholog); chronic obstructive pulmonary disease (ortholog); FOUND IN protein-containing complex; chromosome, telomeric region (ortholog); cytoplasm (ortholog); INTERACTS WITH 2,6-dinitrotoluene; 3-chloropropane-1,2-diol; 4-amino-2,6-dinitrotoluene | 9 | 81404507 | 81493293 | Rat | 254 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 11495 | Xrcc5 | X-ray repair complementing 5 | Predicted to enable several functions, including ATP hydrolysis activity; U3 snoRNA binding activity; and sequence-specific DNA binding activity. Predicted to contribute to 5'-deoxyribose-5-phosphate lyase activity; DNA end binding activity; and double-stranded telomeric DNA binding activity. Acts u pstream of or within several processes, including cellular response to leukemia inhibitory factor; hemopoiesis; and positive regulation of neurogenesis. Located in cytoplasm and nucleus. Is expressed in central nervous system; nasal epithelium; and thymus primordium. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; multiple myeloma; and rectum cancer. Orthologous to human XRCC5 (X-ray repair cross complementing 5). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 72346576 | 72434112 | Mouse | 422 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 733855 | XRCC5 | X-ray repair cross complementing 5 | The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions to gether with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008] | 2 | 216109348 | 216206293 | Human | 315 | symbol , old_gene_name , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8729907 | Xrcc5 | X-ray repair cross complementing 5 | ENCODES a protein that exhibits 5'-deoxyribose-5-phosphate lyase activity (ortholog); ATP hydrolysis activity (ortholog); ATP-dependent activity, acting on DNA (ortholog); INVOLVED IN activation of innate immune response (ortholog); cell population proliferation (ortholog); cellular hyperosmotic sal inity response (ortholog); PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH Animal Disease Models (ortholog); basal cell carcinoma (ortholog); chronic obstructive pulmonary disease (ortholog); FOUND IN chromosome, telomeric region (ortholog); cytoplasm (ortholog); DNA-dependent protein kinase-DNA ligase 4 complex (ortholog) | NW_004955453 | 16967453 | 17054634 | Chinchilla | 94 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12045166 | XRCC5 | X-ray repair cross complementing 5 | ENCODES a protein that exhibits DNA end binding (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN cell population proliferation (ortholog); cellular hyperosmotic salinity response (ortholog); cellular response to fatty acid (ortholog); PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH Animal Disease Models (ortholog); basal cell carcinoma (ortholog); chronic obstructive pulmonary disease (ortholog); FOUND IN protein-containing complex (ortholog) | 2B | 103371459 | 103468419 | Bonobo | 122 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12336490 | XRCC5 | X-ray repair cross complementing 5 | ENCODES a protein that exhibits DNA end binding (ortholog); INVOLVED IN cell population proliferation (ortholog); cellular hyperosmotic salinity response (ortholog); cellular response to fatty acid (ortholog); PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; ASSOCIAT ED WITH Animal Disease Models (ortholog); basal cell carcinoma (ortholog); chronic obstructive pulmonary disease (ortholog); FOUND IN protein-containing complex (ortholog) | 37 | 23095769 | 23185680 | Dog | 121 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12709613 | Xrcc5 | X-ray repair cross complementing 5 | ENCODES a protein that exhibits DNA end binding (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN cell population proliferation (ortholog); cellular hyperosmotic salinity response (ortholog); cellular response to fatty acid (ortholog); PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH Animal Disease Models (ortholog); basal cell carcinoma (ortholog); chronic obstructive pulmonary disease (ortholog); FOUND IN protein-containing complex (ortholog) | NW_004936586 | 1055478 | 1137924 | Squirrel | 119 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13993953 | XRCC5 | X-ray repair cross complementing 5 | ENCODES a protein that exhibits DNA end binding (ortholog); INVOLVED IN cell population proliferation (ortholog); cellular hyperosmotic salinity response (ortholog); cellular response to fatty acid (ortholog); PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; ASSOCIAT ED WITH Animal Disease Models (ortholog); basal cell carcinoma (ortholog); chronic obstructive pulmonary disease (ortholog); FOUND IN protein-containing complex (ortholog) | | | | Pig | 121 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247623 | xrcc5 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626082111 | Xrcc5 | X-ray repair cross complementing 5 | ENCODES a protein that exhibits 5'-deoxyribose-5-phosphate lyase activity (ortholog); ATP hydrolysis activity (ortholog); ATP-dependent activity, acting on DNA (ortholog); INVOLVED IN activation of innate immune response (ortholog); cell population proliferation (ortholog); cellular hyperosmotic sal inity response (ortholog); PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH Animal Disease Models (ortholog); basal cell carcinoma (ortholog); chronic obstructive pulmonary disease (ortholog); FOUND IN chromosome, telomeric region (ortholog); cytoplasm (ortholog); DNA-dependent protein kinase-DNA ligase 4 complex (ortholog) | | | | Black Rat | 94 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18449242 | XRCC5 | X-ray repair cross complementing 5 | ENCODES a protein that exhibits DNA end binding (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN cell population proliferation (ortholog); cellular hyperosmotic salinity response (ortholog); cellular response to fatty acid (ortholog); PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH Animal Disease Models (ortholog); basal cell carcinoma (ortholog); chronic obstructive pulmonary disease (ortholog); FOUND IN protein-containing complex (ortholog) | | | | Green Monkey | 122 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247624 | xrcc5.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 18908098 | LOC101719341 | X-ray repair cross-complementing protein 5 | ENCODES a protein that exhibits ATP binding (inferred); damaged DNA binding (inferred); DNA binding (inferred); INVOLVED IN DNA damage response (inferred); DNA recombination (inferred); DNA repair (inferred); FOUND IN chromosome (inferred); cytoplasm (inferred); Ku70:Ku80 complex (inferred) | | | | Naked Mole-Rat | 30 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1605104 | CEP170 | centrosomal protein 170 | The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] | 1 | 243124428 | 243255785 | Human | 94 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 14157527 | TMEM169 | transmembrane protein 169 | ENCODES a protein that exhibits 5'-deoxyribose-5-phosphate lyase activity (inferred); ATP binding (inferred); ATP hydrolysis activity (inferred); INVOLVED IN activation of innate immune response (inferred); cellular response to gamma radiation (inferred); DNA damage response (inferred); FOUND IN chr omosome (inferred); chromosome, telomeric region (inferred); cytoplasm (inferred) | | | | Pig | 65 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
