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Gene: Xrcc5 (X-ray repair complementing defective repair in Chinese hamster cells 5) Mus musculus
Symbol: Xrcc5
Name: X-ray repair complementing defective repair in Chinese hamster cells 5
Description: Predicted to contribute to 5'-deoxyribose-5-phosphate lyase activity and double-stranded telomeric DNA binding activity. Involved in several processes, including cellular response to leukemia inhibitory factor; double-strand break repair; and hematopoietic stem cell differentiation. Localizes to the cytoplasm and nucleus. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease and multiple myeloma. Is expressed in thymus primordium. Orthologous to human XRCC5 (X-ray repair cross complementing 5); PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; INTERACTS WITH 17alpha-ethynylestradiol; 4,4'-diaminodiphenylmethane; 4-amino-1,8-naphthalimide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI314015; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; ku autoantigen protein p86 homolog; Ku p80; Ku80; Ku86; nuclear factor IV; X-ray repair cross-complementing protein 5
Homo sapiens (human) : XRCC5 (X-ray repair cross complementing 5)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Xrcc5 (X-ray repair cross complementing 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Xrcc5 (X-ray repair cross complementing 5)
Pan paniscus (bonobo/pygmy chimpanzee) : XRCC5 (X-ray repair cross complementing 5)
Canis lupus familiaris (dog) : XRCC5 (X-ray repair cross complementing 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Xrcc5 (X-ray repair cross complementing 5)
Sus scrofa (pig) : XRCC5 (X-ray repair cross complementing 5)
Chlorocebus sabaeus (African green monkey) : XRCC5 (X-ray repair cross complementing 5)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl172,307,427 - 72,394,952 (+)Ensembl
GRCm38172,307,417 - 72,394,953 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37172,353,995 - 72,441,527 (+)NCBIGRCm37mm9NCBIm37
MGSCv36172,240,728 - 72,328,156 (+)NCBImm8
Celera172,875,673 - 72,963,703 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map136.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Xrcc5
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11495
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-02-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.