| 1307644 | Wnt8b | Wnt family member 8B | ENCODES a protein that exhibits receptor ligand activity (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); negative regulation of gene expression (ortholog); positive regulation of gene expression (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; basal cell carcinoma pathway; ASSOCIATED WITH Hirschsprung's disease (ortholog); FOUND IN extracellular region (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A | 1 | 253303369 | 253325224 | Rat | 60 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1316953 | WNT8B | Wnt family member 8B | The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy. [provided by RefSeq, Jul 2008] | 10 | 100463009 | 100483744 | Human | 67 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1316954 | Wnt8b | wingless-type MMTV integration site family, member 8B | Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within negative regulation of gene expression and positive regulation of gene expression. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several s tructures, including cochlea; eye; future brain; head mesenchyme; and nervous system. Human ortholog(s) of this gene implicated in Hirschsprung's disease. Orthologous to human WNT8B (Wnt family member 8B). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 44481912 | 44502712 | Mouse | 62 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8741504 | Wnt8b | Wnt family member 8B | ENCODES a protein that exhibits receptor ligand activity (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); negative regulation of gene expression (ortholog); positive regulation of gene expression (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Hirschsprung's disease (ortholog) | NW_004955485 | 9658432 | 9679371 | Chinchilla | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11732006 | WNT8B | Wnt family member 8B | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); receptor ligand activity (inferred); INVOLVED IN negative regulation of gene expression (ortholog); positive regulation of gene expression (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, cano nical pathway; ASSOCIATED WITH Hirschsprung's disease (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred) | 10 | 97079996 | 97083933 | Bonobo | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12386209 | WNT8B | Wnt family member 8B | ENCODES a protein that exhibits receptor ligand activity (inferred); signaling receptor binding (inferred); INVOLVED IN negative regulation of gene expression (ortholog); positive regulation of gene expression (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOC IATED WITH Hirschsprung's disease (ortholog); FOUND IN extracellular region (inferred) | 28 | 13187927 | 13210398 | Dog | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12533274 | Wnt8b | Wnt family member 8B | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); receptor ligand activity (inferred); INVOLVED IN negative regulation of gene expression (ortholog); positive regulation of gene expression (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, cano nical pathway; ASSOCIATED WITH Hirschsprung's disease (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred) | NW_004936600 | 5163940 | 5187098 | Squirrel | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14040265 | WNT8B | Wnt family member 8B | ENCODES a protein that exhibits receptor ligand activity (inferred); signaling receptor binding (inferred); INVOLVED IN negative regulation of gene expression (ortholog); positive regulation of gene expression (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOC IATED WITH Hirschsprung's disease (ortholog); FOUND IN extracellular region (inferred) | | | | Pig | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18902899 | Wnt8b | Wnt family member 8B | ENCODES a protein that exhibits receptor ligand activity (ortholog); INVOLVED IN negative regulation of gene expression (ortholog); positive regulation of gene expression (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Hirschsprung's disease (orth olog); FOUND IN extracellular region (inferred); extracellular space (inferred) | | | | Naked Mole-Rat | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155241562 | wnt8b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18549053 | WNT8B | Wnt family member 8B | ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); receptor ligand activity (inferred); INVOLVED IN negative regulation of gene expression (ortholog); positive regulation of gene expression (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, cano nical pathway; ASSOCIATED WITH Hirschsprung's disease (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred) | | | | Green Monkey | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625966762 | Wnt8b | Wnt family member 8B | ENCODES a protein that exhibits receptor ligand activity (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); negative regulation of gene expression (ortholog); positive regulation of gene expression (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Hirschsprung's disease (ortholog) | | | | Black Rat | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405855907 | wnt8b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858432 | wnt8b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862789 | wnt8b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626182181 | wnt8b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859875 | wnt8b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155256674 | wnt8b.S | | | | | | African Clawed Frog | | symbol | gene, null |