| 1308038 | Vps11 | VPS11 core subunit of CORVET and HOPS complexes | ENCODES a protein that exhibits molecular adaptor activity (ortholog); protein domain specific binding (ortholog); syntaxin binding (ortholog); INVOLVED IN autophagosome-lysosome fusion (ortholog); endosomal vesicle fusion (ortholog); endosome to lysosome transport (ortholog); ASSOCIATED WITH dyston ia 32 (ortholog); genetic disease (ortholog); hypomyelinating leukodystrophy 12 (ortholog); FOUND IN actin filament (ortholog); AP-3 adaptor complex (ortholog); CORVET complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; bisphenol A | 8 | 53580939 | 53595378 | Rat | 122 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1317575 | VPS11 | VPS11 core subunit of CORVET and HOPS complexes | Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of ye ast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] | 11 | 119067818 | 119081972 | Human | 189 | symbol , old_gene_name , COSMIC , name , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1317576 | Vps11 | VPS11, CORVET/HOPS core subunit | Predicted to enable several functions, including protein domain specific binding activity; syntaxin binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of intracellular estrogen receptor signaling pathway; positive reg ulation of early endosome to late endosome transport; and vesicle organization. Located in actin filament and early endosome. Part of AP-3 adaptor complex and CORVET complex. Is active in presynaptic active zone. Human ortholog(s) of this gene implicated in dystonia 32 and hypomyelinating leukodystrophy 12. Orthologous to human VPS11 (VPS11 core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Apr 2025] | 9 | 44259046 | 44272970 | Mouse | 111 | symbol , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8791457 | Vps11 | VPS11 core subunit of CORVET and HOPS complexes | ENCODES a protein that exhibits molecular adaptor activity (ortholog); protein domain specific binding (ortholog); syntaxin binding (ortholog); INVOLVED IN autophagosome-lysosome fusion (ortholog); endosomal vesicle fusion (ortholog); endosome to lysosome transport (ortholog); ASSOCIATED WITH dyston ia 32 (ortholog); genetic disease (ortholog); hypomyelinating leukodystrophy 12 (ortholog); FOUND IN actin filament (ortholog); AP-3 adaptor complex (ortholog); CORVET complex (ortholog) | NW_004955412 | 20161520 | 20190141 | Chinchilla | 50 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11901528 | VPS11 | VPS11 core subunit of CORVET and HOPS complexes | ENCODES a protein that exhibits molecular adaptor activity (ortholog); protein domain specific binding (ortholog); syntaxin binding (ortholog); INVOLVED IN autophagosome-lysosome fusion (ortholog); endosomal vesicle fusion (ortholog); endosome to lysosome transport (ortholog); ASSOCIATED WITH dyston ia 32 (ortholog); genetic disease (ortholog); hypomyelinating leukodystrophy 12 (ortholog); FOUND IN AP-3 adaptor complex (ortholog); endocytic vesicle (ortholog); late endosome (ortholog) | 11 | 113905989 | 113920163 | Bonobo | 80 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12332522 | VPS11 | VPS11 core subunit of CORVET and HOPS complexes | ENCODES a protein that exhibits molecular adaptor activity (ortholog); protein domain specific binding (ortholog); syntaxin binding (ortholog); INVOLVED IN autophagosome-lysosome fusion (ortholog); endosomal vesicle fusion (ortholog); endosome to lysosome transport (ortholog); ASSOCIATED WITH hypomy elinating leukodystrophy 12; dystonia 32 (ortholog); genetic disease (ortholog); FOUND IN AP-3 adaptor complex (ortholog); endocytic vesicle (ortholog); late endosome (ortholog) | 5 | 14776975 | 14786736 | Dog | 80 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12615562 | Vps11 | VPS11 core subunit of CORVET and HOPS complexes | ENCODES a protein that exhibits molecular adaptor activity (ortholog); protein domain specific binding (ortholog); syntaxin binding (ortholog); INVOLVED IN autophagosome-lysosome fusion (ortholog); endosomal vesicle fusion (ortholog); endosome to lysosome transport (ortholog); ASSOCIATED WITH dyston ia 32 (ortholog); genetic disease (ortholog); hypomyelinating leukodystrophy 12 (ortholog); FOUND IN AP-3 adaptor complex (ortholog); endocytic vesicle (ortholog); late endosome (ortholog) | NW_004936542 | 4022928 | 4035577 | Squirrel | 79 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18696629 | VPS11 | VPS11 core subunit of CORVET and HOPS complexes | ENCODES a protein that exhibits molecular adaptor activity (ortholog); protein domain specific binding (ortholog); syntaxin binding (ortholog); INVOLVED IN autophagosome-lysosome fusion (ortholog); endosomal vesicle fusion (ortholog); endosome to lysosome transport (ortholog); ASSOCIATED WITH dyston ia 32 (ortholog); genetic disease (ortholog); hypomyelinating leukodystrophy 12 (ortholog); FOUND IN AP-3 adaptor complex (ortholog); endocytic vesicle (ortholog); late endosome (ortholog) | | | | Green Monkey | 80 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14381403 | Vps11 | | | | | | Fly | | symbol | gene, null |
| 625838761 | Vps11 | VPS11 core subunit of CORVET and HOPS complexes | ENCODES a protein that exhibits molecular adaptor activity (ortholog); protein domain specific binding (ortholog); syntaxin binding (ortholog); INVOLVED IN autophagosome-lysosome fusion (ortholog); endosomal vesicle fusion (ortholog); endosome to lysosome transport (ortholog); ASSOCIATED WITH dyston ia 32 (ortholog); genetic disease (ortholog); hypomyelinating leukodystrophy 12 (ortholog); FOUND IN actin filament (ortholog); AP-3 adaptor complex (ortholog); CORVET complex (ortholog) | | | | Black Rat | 50 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18935163 | Vps11 | VPS11 core subunit of CORVET and HOPS complexes | ENCODES a protein that exhibits molecular adaptor activity (ortholog); protein domain specific binding (ortholog); syntaxin binding (ortholog); INVOLVED IN autophagosome-lysosome fusion (ortholog); endosomal vesicle fusion (ortholog); endosome to lysosome transport (ortholog); ASSOCIATED WITH dyston ia 32 (ortholog); genetic disease (ortholog); hypomyelinating leukodystrophy 12 (ortholog); FOUND IN AP-3 adaptor complex (ortholog); endocytic vesicle (ortholog); late endosome (ortholog) | | | | Naked Mole-Rat | 80 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14155022 | VPS11 | VPS11 core subunit of CORVET and HOPS complexes | ENCODES a protein that exhibits molecular adaptor activity (ortholog); protein domain specific binding (ortholog); syntaxin binding (ortholog); INVOLVED IN autophagosome-lysosome fusion (ortholog); endosomal vesicle fusion (ortholog); endosome to lysosome transport (ortholog); ASSOCIATED WITH dyston ia 32 (ortholog); genetic disease (ortholog); hypomyelinating leukodystrophy 12 (ortholog); FOUND IN AP-3 adaptor complex (ortholog); endocytic vesicle (ortholog); late endosome (ortholog) | | | | Pig | 79 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155250186 | vps11 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155250185 | vps11.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155233504 | vps11.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16566293 | VPS11-DT | VPS11 divergent transcript | | | | | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, lncrna |
| 39128293 | VPS11-DT | VPS11 divergent transcript | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna |
