VPS11 (VPS11 core subunit of CORVET and HOPS complexes)

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Gene: VPS11 (VPS11 core subunit of CORVET and HOPS complexes) Sus scrofa

Analyze

Symbol:

VPS11

Name:

VPS11 core subunit of CORVET and HOPS complexes

RGD ID:

14155022

Description:

ENCODES a protein that exhibits protein domain specific binding (ortholog); syntaxin binding (ortholog); ubiquitin protein ligase activity (ortholog); INVOLVED IN endosomal vesicle fusion (ortholog); endosome to lysosome transport (ortholog); negative regulation of intracellular estrogen receptor signaling pathway (ortholog); ASSOCIATED WITH Dwarfism (ortholog); Glycogen Storage Disease IB (ortholog); hypomyelinating leukodystrophy 12 (ortholog); FOUND IN actin filament (ortholog); AP-3 adaptor complex (ortholog); CORVET complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Also known as:

vacuolar protein sorting-associated protein 11 homolog; VPS11, CORVET/HOPS core subunit

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	46,285,729 - 46,297,465 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	46,285,718 - 46,297,465 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	51,320,856 - 51,332,600 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Dwarfism (ISO)

Glycogen Storage Disease IB (ISO)

hypomyelinating leukodystrophy 12 (ISO)

immunodeficiency 19 (ISO)

Leukoencephalopathies (ISO)

long QT syndrome 10 (ISO)

schizophrenia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autophagy (IEA)

endosomal vesicle fusion (ISO)

endosome organization (IBA)

endosome to lysosome transport (ISO)

intracellular protein transport (IEA)

negative regulation of intracellular estrogen receptor signaling pathway (ISO)

positive regulation of cellular protein catabolic process (ISO)

positive regulation of early endosome to late endosome transport (ISO)

positive regulation of protein targeting to mitochondrion (ISO)

protein ubiquitination (ISO)

regulation of organelle assembly (ISO)

regulation of protein stability (ISO)

regulation of SNARE complex assembly (IBA)

toxin transport (IEA,ISO)

vacuole organization (IBA)

vesicle docking involved in exocytosis (IBA)

Cellular Component

actin filament (IEA,ISO)

AP-3 adaptor complex (IEA,ISO)

autophagosome (IEA)

clathrin-coated vesicle (IEA)

CORVET complex (IEA,ISO)

early endosome (IEA,ISO)

endocytic vesicle (ISO)

endosome (IBA,ISO)

HOPS complex (IBA)

late endosome (ISO)

late endosome membrane (IEA)

lysosomal membrane (IEA)

lysosome (ISO)

presynaptic active zone (IEA,ISO)

Molecular Function

metal ion binding (IEA)

protein binding (ISO)

protein domain specific binding (ISO)

protein-macromolecule adaptor activity (IBA)

syntaxin binding (ISO)

ubiquitin protein ligase activity (ISO)

References

Genomics

Comparative Map Data

VPS11
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	46,285,729 - 46,297,465 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	46,285,718 - 46,297,465 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	51,320,856 - 51,332,600 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

VPS11
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	11	119,067,692 - 119,081,978 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38.p13 Ensembl	11	119,067,818 - 119,081,972 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	11	119,067,792 - 119,081,972 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	11	118,938,493 - 118,952,688 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
GRCh37	11	118,938,529 - 118,952,682 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	118,443,703 - 118,457,898 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	11	118,443,702 - 118,457,884	NCBI
Celera	11	116,096,175 - 116,110,109 (+)	NCBI
Cytogenetic Map	11	q23.3	NCBI
HuRef	11	114,878,034 - 114,892,141 (+)	NCBI		HuRef
CHM1_1	11	118,824,741 - 118,838,977 (+)	NCBI		CHM1_1

Vps11
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	44,259,046 - 44,272,970 (-)	NCBI	GRCm39		mm39
GRCm38	9	44,347,749 - 44,361,673 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	44,347,749 - 44,361,670 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	44,156,188 - 44,169,753 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	9	44,099,100 - 44,112,665 (-)	NCBI			mm8
Celera	9	41,603,071 - 41,616,610 (-)	NCBI		Celera
Cytogenetic Map	9	A5.2	NCBI

Vps11
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	44,683,768 - 44,698,572 (-)	NCBI
Rnor_6.0 Ensembl	8	48,677,492 - 48,692,295 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	8	48,677,492 - 48,692,295 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	8	47,296,463 - 47,311,266 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	47,324,449 - 47,339,252 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	8	47,333,277 - 47,348,018 (-)	NCBI
Celera	8	44,270,001 - 44,284,802 (-)	NCBI		Celera
Cytogenetic Map	8	q22	NCBI

Vps11
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	20,177,623 - 20,190,141 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955412	20,161,520 - 20,190,141 (+)	NCBI	ChiLan1.0	ChiLan1.0

VPS11
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	11	117,835,497 - 117,849,389 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	117,835,557 - 117,849,389 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	11	113,905,989 - 113,920,163 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

VPS11
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	5	14,776,976 - 14,786,692 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	5	14,776,975 - 14,786,736 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Vps11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936542	4,022,928 - 4,035,577 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

VPS11
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	110,440,681 - 110,455,092 (+)	NCBI
ChlSab1.1 Ensembl	1	110,439,933 - 110,455,844 (+)	Ensembl

Vps11
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624784	14,452,811 - 14,464,965 (+)	NCBI

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
High
Medium	1	2	3	5	1	22	2	1	3
Low	9	2			1	1		2
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003129923	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021062957	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000070	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK393711	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU639481	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU695209	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01105596	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSSSCT00000016473 ⟹ ENSSSCP00000016030

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	9	46,285,729 - 46,297,465 (+)	Ensembl

RefSeq Acc Id:

XM_003129923 ⟹ XP_003129971

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	9	46,285,718 - 46,297,465 (+)	NCBI

Sequence:

show sequence

TCTTCTCACGTGACCTCTCTCGCGGAGGCGGGGGCCGTCGGCCAAGATGGCGGCCTACCTGCAG
TGGCGGCGCTTCGTTTTCTTCGACAAGGAGCTGGTGAAAGAGCCGCTGGGCAATGATGGAGCTG
CTCCCGGGCCCGCACCTGCCTCTGCACCTGCTGCTTCCAAGTTCCTTTGCCTCCCTCCTGGCAT
CACTGTCTGCGACTCAGGCCGAGGGAGCCTAGTCTTTGGAGATATGGAAGGCCAGATCTGGTTC
TTGCCCCGCTCCTTACAGCTTACGGGTTTCCAGGCCTACAAATTACGGGTGACACACCTGTACC
AACTGAAACAGCACAATATTTTGGCATCTGTTGGTGAGGATGAAGAGGGCATCAACCCCTTGGT
AAAGATCTGGAACCTGGAGAAGAGAGATGGTGGCAATCCACTCTGCACTCGGATCTTCCCTGCC
ATTCCAGGGACAGAGCCAACTGTCGTGTCTTGTTTGACTGTCCATGAAAATCTCAACTTTATGG
CCATTGGTTTTACAGATGGCAGTGTTACATTGAACAAAGGGGACATCACCCGGGACCGGCATAG
CAAGACCCAGATTTTGCACAAGGGCAACTATCCTGTTACGGGACTGGCCTTTCGCCAAGCAGGA
AAGACCACTCACTTGTTTGTTGTGACAACCGAGAATGTTCAGTCCTACATAGTTTCTGGAAAGG
ACTACCCTCGTGTGGAGTTGGACACCCATGGTTGTGGCCTGCGCTGCTCAGCTCTAAGCGACCC
TTCTCAGGACATGCAGTTCATAGTGGCGGGGGATGAGTGTGTCTACTTGTACCAGCCGGATGAA
CGTGGGCCCTGCTTCGCCTTTGAGGGCCATAAACTCATTGCTCACTGGTTTAGAGGCTACCTTG
TCATTGTCTCCCGTGATCGGAAAGTTTCTCCCAAGTCGGAGTTTACCAGCAGGGATTCCCAGAG
CTCCGACAAGCAGATTCTCAACATCTATGACCTGTGCAACAAGTTCATAGCCTACAGCGCCGTC
TTTGAGGATGTAGTGGATGTGCTTGCCGAGTGGGGCTCCCTGTACGTGCTGACGCGGGATGGGC
GGGTCCACGCACTGCAGGAGAAGGACACACAGACCAAACTGGAGATGCTGTTTAAGAAGAATCT
GTTTGAGATGGCGATCAACCTGGCCAAGAGCCAGCATCTGGACAGTGATGGGTTGGCCCAGATC
TTCATGCAGTATGGGGACCACCTCTACAGCAAGGGCAACCATGATGGGGCTGTCCAGCAGTATA
TCCGAACCATTGGAAAGTTGGAGCCATCCTATGTGATCCGCAAGTTTCTGGATGCCCAGCGCAT
CCACAACCTGACAGCCTACCTGCAGACCCTGCACCGGCAGTCCCTGGCCAATGCCGACCACACC
ACCCTTCTGCTCAACTGCTACACCAAGCTCAAGGACAGCTCGAAGCTGGAGGAGTTCATCAAGA
CAAAGAGTGAGAGCGAGGTCCACTTTGATGTGGAGACAGCCATCAAGGTTCTCCGGCAGGCCGG
CTACTACTCCCACGCCCTCTACTTGGCTGAGAACCACGCACATCACGAGTGGTACTTGAAGATC
CAGCTAGAGGACATCAAGAATTATCAGGAAGCCCTTCGGTACATCGGAAAGCTGCCTTTTGAGC
AGGCAGAGAGCAACATGAAACGCTATGGCAAGACCCTCATGCACCATATACCAGAGCAGACCAC
CCAGTTGCTGAAAGGACTCTGCACCAACTATCAGCCCAGCCTTGAAGGCCGAGGCGATAGGGAG
GCTCCCGGCTGCAGGGCCAACTCAGAGGAGTTCATCCCCATCTTTGCCAACAACCCTCGGGAGT
TGAAAGCTTTCCTAGAGCACATGAGTGAGGTACAGCCTGACTCCCCACAGGGCATCTACGACAC
ACTCCTTGAACTGCGACTCCAGAACTGGGCCCACGAGGAAGATCCGCAGGTCAAAGAGAAGCTT
CACGCGGAGGCCATCTCTCTCCTGAAGAGTGGTCGCTTCTGTGACGTCTTTGACAAAGCCCTGG
TCCTCTGCCAGATGCACGACTTCCAGGATGGGGTCCTTTACCTCTATGAGCAGGGGAAACTGTT
CCAGCAGATCATGCACTACCACATGCAGCACGAGCAGTACCGGCAGGTGATCGCCGTGTGCGAG
CGCCACGGGGAGCAGGAGCCCTCCCTGTGGGAGCAGGCGCTCAGCTACTTCGCCCGCAAGGAGG
AGGACTGCAAGGAGTATGTGGCGGCCGTGCTCAAGCACATCGAGAGCAAGAATCTCATGCCACC
CCTTCTAGTGGTGCAGACCTTGGCCCACAATTCCACAGCCACCCTGTCTGTCATTCGGGACTAC
CTGGTCCAAAAGCTGCAGAAACAGAGCCAGCAAATCGCCCAGGATGAGCTCCGGGTGCGGCGCT
ACCGAGAGGAGACCACCCGCATCCGCCAGGAGATCCAGGAGCTGAAGGCAAGTCCAAAGATTTT
CCAGAAGACCAAGTGCAGCATCTGTAACAGTGCCTTGGAGTTGCCCTCTGTCCACTTTCTCTGC
GGCCACTCCTTCCACCAGCACTGCTTTGAGAGTTACTCGGAAAGTGATGCCGACTGCCCCACCT
GCCTCCCTGAAAACCGCAAGGTCATGGATATGATCCGGGCTCAGGAACAGAAGCGAGATCTCCA
CGATCAATTCCAGCACCAGCTCAAGTGCTCCAATGACAGCTTCTCTGTGATTGCCGATTACTTT
GGCAGAGGTGTTTTCAACAAATTGACTCTGCTGACCGACCCACCCCCAGCCCGGCTGACTTCGA
GCCTGGAGGCCGGACTGCAGCGGGACTTGCTCATGCACTCCAGAAGGGGCACCTAGGCGGCTGG
TGGGAAGGGGTATGATGGCGGAGGCCCAGCAGCAGGGACATGGGGACAGAGGCAGGGCTCTTGC
ACAGGAGTCAGGCAGACATGCCCAGGACTCCACTCTCCTCTGATGCCATGGTCTTCAGACCTTA
AGGGGACTTTGTTTTCCTGCCTCCTTCATTGGCCAACCCGCCATTCCCCCTGTTGACTTTTTGA
GCAGTGTAGATCATTCCAGACCAGTGGGGGAGGGTACCTCAGCAACCTCGGGGTCTGGACAATA
GCTACTTTATTCTCTGTCCAAGAGCACCAGGCTGTGCTTGGGTCCTGGCTCGCAGAGTCTATAA
ATAAAAGAATATAATGATTTCA

hide sequence

RefSeq Acc Id:

XM_021062957 ⟹ XP_020918616

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	9	46,285,718 - 46,297,465 (+)	NCBI

Sequence:

show sequence

TCTTCTCACGTGACCTCTCTCGCGGAGGCGGGGGCCGTCGGCCAAGATGGCGGCCTACCTGCAG
TGGCGGCGCTTCGTTTTCTTCGACAAGGAGCTGGTGAAAGAGCCGCTGGGCAATGATGGAGCTG
CTCCCGGGCCCGCACCTGCCTCTGCACCTGCTGCTTCCAAGTTCCTTTGCCTCCCTCCTGGCAT
CACTGTCTGCGACTCAGGCCGAGGGAGCCTAGTCTTTGGAGATATGGAAGGCCAGATCTGGTTC
TTGCCCCGCTCCTTACAGCTTACGGGTTTCCAGGCCTACAAATTACGGGTGACACACCTGTACC
AACTGAAACAGCACAATATTTTGGCATCTGTTGGTGAGGATGAAGAGGGCATCAACCCCTTGGT
AAAGATCTGGAACCTGGAGAAGAGAGATGGTGGCAATCCACTCTGCACTCGGATCTTCCCTGCC
ATTCCAGGGACAGAGCCAACTGTCGTGTCTTGTTTGACTGTCCATGAAAATCTCAACTTTATGG
CCATTGGTTTTACAGATGGCAGTGTTACATTGAACAAAGGGGACATCACCCGGGACCGGCATAG
CAAGACCCAGATTTTGCACAAGGGCAACTATCCTGTTACGGGACTGGCCTTTCGCCAAGCAGGA
AAGACCACTCACTTGTTTGTTGTGACAACCGAGAATGTTCAGTCCTACATAGTTTCTGGAAAGG
ACTACCCTCGTGTGGAGTTGGACACCCATGGTTGTGGCCTGCGCTGCTCAGCTCTAAGCGACCC
TTCTCAGGACATGCAGTTCATAGTGGCGGGGGATGAGTGTGTCTACTTGTACCAGCCGGATGAA
CGTGGGCCCTGCTTCGCCTTTGAGGGCCATAAACTCATTGCTCACTGGTTTAGAGGCTACCTTG
TCATTGTCTCCCGTGATCGGAAAGTTTCTCCCAAGTCGGAGTTTACCAGCAGGGATTCCCAGAG
CTCCGACAAGCAGATTCTCAACATCTATGACCTGTGCAACAAGTTCATAGCCTACAGCGCCGTC
TTTGAGGATGTAGTGGATGTGCTTGCCGAGTGGGGCTCCCTGTACGTGCTGACGCGGGATGGGC
GGGTCCACGCACTGCAGGAGAAGGACACACAGACCAAACTGGAGATGCTGTTTAAGAAGAATCT
GTTTGAGATGGCGATCAACCTGGCCAAGAGCCAGCATCTGGACAGTGATGGGTTGGCCCAGATC
TTCATGCAGTATGGGGACCACCTCTACAGCAAGGGCAACCATGATGGGGCTGTCCAGCAGTATA
TCCGAACCATTGGAAAGTTGGAGCCATCCTATGTGATCCGCAAGTTTCTGGATGCCCAGCGCAT
CCACAACCTGACAGCCTACCTGCAGACCCTGCACCGGCAGTCCCTGGCCAATGCCGACCACACC
ACCCTTCTGCTCAACTGCTACACCAAGCTCAAGGACAGCTCGAAGCTGGAGGAGTTCATCAAGA
CAAAGAGTGAGAGCGAGGTCCACTTTGATGTGGAGACAGCCATCAAGGTTCTCCGGCAGGCCGG
CTACTACTCCCACGCCCTCTACTTGGCTGAGAACCACGCACATCACGAGTGGTACTTGAAGATC
CAGCTAGAGGACATCAAGAATTATCAGGAAGCCCTTCGGTACATCGGAAAGCTGCCTTTTGAGC
AGGCAGAGAGCAACATGAAACGCTATGGCAAGACCCTCATGCACCATATACCAGAGCAGACCAC
CCAGTTGCTGAAAGGACTCTGCACCAACTATCAGCCCAGCCTTGAAGGCCGAGGCGATAGGGAG
GCTCCCGGCTGCAGGGCCAACTCAGAGGAGTTCATCCCCATCTTTGCCAACAACCCTCGGGAGT
TGAAAGCTTTCCTAGAGCACATGAGTGAGGTACAGCCTGACTCCCCACAGGGCATCTACGACAC
ACTCCTTGAACTGCGACTCCAGAACTGGGCCCACGAGGAAGATCCGCAGGTCAAAGAGAAGCTT
CACGCGGAGGCCATCTCTCTCCTGAAGAGTGGTCGCTTCTGTGACGTCTTTGACAAAGCCCTGG
TCCTCTGCCAGATGCACGACTTCCAGGATGGGGTCCTTTACCTCTATGAGCAGGGGAAACTGTT
CCAGCAGATCATGCACTACCACATGCAGCACGAGCAGTACCGGCAGGTGATCGCCGTGTGCGAG
CGCCACGGGGAGCAGGAGCCCTCCCTGTGGGAGCAGGCGCTCAGCTACTTCGCCCGCAAGGAGG
AGGACTGCAAGGAGTATGTGGCGGCCGTGCTCAAGCACATCGAGAGCAAGAATCTCATGCCACC
CCTTCTAGCCACCCTGTCTGTCATTCGGGACTACCTGGTCCAAAAGCTGCAGAAACAGAGCCAG
CAAATCGCCCAGGATGAGCTCCGGGTGCGGCGCTACCGAGAGGAGACCACCCGCATCCGCCAGG
AGATCCAGGAGCTGAAGGCAAGTCCAAAGATTTTCCAGAAGACCAAGTGCAGCATCTGTAACAG
TGCCTTGGAGTTGCCCTCTGTCCACTTTCTCTGCGGCCACTCCTTCCACCAGCACTGCTTTGAG
AGTTACTCGGAAAGTGATGCCGACTGCCCCACCTGCCTCCCTGAAAACCGCAAGGTCATGGATA
TGATCCGGGCTCAGGAACAGAAGCGAGATCTCCACGATCAATTCCAGCACCAGCTCAAGTGCTC
CAATGACAGCTTCTCTGTGATTGCCGATTACTTTGGCAGAGGTGTTTTCAACAAATTGACTCTG
CTGACCGACCCACCCCCAGCCCGGCTGACTTCGAGCCTGGAGGCCGGACTGCAGCGGGACTTGC
TCATGCACTCCAGAAGGGGCACCTAGGCGGCTGGTGGGAAGGGGTATGATGGCGGAGGCCCAGC
AGCAGGGACATGGGGACAGAGGCAGGGCTCTTGCACAGGAGTCAGGCAGACATGCCCAGGACTC
CACTCTCCTCTGATGCCATGGTCTTCAGACCTTAAGGGGACTTTGTTTTCCTGCCTCCTTCATT
GGCCAACCCGCCATTCCCCCTGTTGACTTTTTGAGCAGTGTAGATCATTCCAGACCAGTGGGGG
AGGGTACCTCAGCAACCTCGGGGTCTGGACAATAGCTACTTTATTCTCTGTCCAAGAGCACCAG
GCTGTGCTTGGGTCCTGGCTCGCAGAGTCTATAAATAAAAGAATATAATGATTTCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003129971	(Get FASTA)	NCBI Sequence Viewer
	XP_020918616	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	XP_003129971 ⟸ XM_003129923
- Peptide Label:	isoform X1
- UniProtKB:	F1SAH7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAYLQWRRFVFFDKELVKEPLGNDGAAPGPAPASAPAASKFLCLPPGITVCDSGRGSLVFGDM EGQIWFLPRSLQLTGFQAYKLRVTHLYQLKQHNILASVGEDEEGINPLVKIWNLEKRDGGNPLC TRIFPAIPGTEPTVVSCLTVHENLNFMAIGFTDGSVTLNKGDITRDRHSKTQILHKGNYPVTGL AFRQAGKTTHLFVVTTENVQSYIVSGKDYPRVELDTHGCGLRCSALSDPSQDMQFIVAGDECVY LYQPDERGPCFAFEGHKLIAHWFRGYLVIVSRDRKVSPKSEFTSRDSQSSDKQILNIYDLCNKF IAYSAVFEDVVDVLAEWGSLYVLTRDGRVHALQEKDTQTKLEMLFKKNLFEMAINLAKSQHLDS DGLAQIFMQYGDHLYSKGNHDGAVQQYIRTIGKLEPSYVIRKFLDAQRIHNLTAYLQTLHRQSL ANADHTTLLLNCYTKLKDSSKLEEFIKTKSESEVHFDVETAIKVLRQAGYYSHALYLAENHAHH EWYLKIQLEDIKNYQEALRYIGKLPFEQAESNMKRYGKTLMHHIPEQTTQLLKGLCTNYQPSLE GRGDREAPGCRANSEEFIPIFANNPRELKAFLEHMSEVQPDSPQGIYDTLLELRLQNWAHEEDP QVKEKLHAEAISLLKSGRFCDVFDKALVLCQMHDFQDGVLYLYEQGKLFQQIMHYHMQHEQYRQ VIAVCERHGEQEPSLWEQALSYFARKEEDCKEYVAAVLKHIESKNLMPPLLVVQTLAHNSTATL SVIRDYLVQKLQKQSQQIAQDELRVRRYREETTRIRQEIQELKASPKIFQKTKCSICNSALELP SVHFLCGHSFHQHCFESYSESDADCPTCLPENRKVMDMIRAQEQKRDLHDQFQHQLKCSNDSFS VIADYFGRGVFNKLTLLTDPPPARLTSSLEAGLQRDLLMHSRRGT hide sequence

RefSeq Acc Id:

XP_020918616 ⟸ XM_021062957

- Peptide Label:

isoform X2

- Sequence:

show sequence

MAAYLQWRRFVFFDKELVKEPLGNDGAAPGPAPASAPAASKFLCLPPGITVCDSGRGSLVFGDM
EGQIWFLPRSLQLTGFQAYKLRVTHLYQLKQHNILASVGEDEEGINPLVKIWNLEKRDGGNPLC
TRIFPAIPGTEPTVVSCLTVHENLNFMAIGFTDGSVTLNKGDITRDRHSKTQILHKGNYPVTGL
AFRQAGKTTHLFVVTTENVQSYIVSGKDYPRVELDTHGCGLRCSALSDPSQDMQFIVAGDECVY
LYQPDERGPCFAFEGHKLIAHWFRGYLVIVSRDRKVSPKSEFTSRDSQSSDKQILNIYDLCNKF
IAYSAVFEDVVDVLAEWGSLYVLTRDGRVHALQEKDTQTKLEMLFKKNLFEMAINLAKSQHLDS
DGLAQIFMQYGDHLYSKGNHDGAVQQYIRTIGKLEPSYVIRKFLDAQRIHNLTAYLQTLHRQSL
ANADHTTLLLNCYTKLKDSSKLEEFIKTKSESEVHFDVETAIKVLRQAGYYSHALYLAENHAHH
EWYLKIQLEDIKNYQEALRYIGKLPFEQAESNMKRYGKTLMHHIPEQTTQLLKGLCTNYQPSLE
GRGDREAPGCRANSEEFIPIFANNPRELKAFLEHMSEVQPDSPQGIYDTLLELRLQNWAHEEDP
QVKEKLHAEAISLLKSGRFCDVFDKALVLCQMHDFQDGVLYLYEQGKLFQQIMHYHMQHEQYRQ
VIAVCERHGEQEPSLWEQALSYFARKEEDCKEYVAAVLKHIESKNLMPPLLATLSVIRDYLVQK
LQKQSQQIAQDELRVRRYREETTRIRQEIQELKASPKIFQKTKCSICNSALELPSVHFLCGHSF
HQHCFESYSESDADCPTCLPENRKVMDMIRAQEQKRDLHDQFQHQLKCSNDSFSVIADYFGRGV
FNKLTLLTDPPPARLTSSLEAGLQRDLLMHSRRGT

hide sequence

RefSeq Acc Id:

ENSSSCP00000016030 ⟸ ENSSSCT00000016473

Protein Domains

RING-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000015107	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00070001105	UniProtKB/TrEMBL
Ensembl Protein	ENSSSCP00000016030	ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCP00070001772	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000016473	ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCT00070002121	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.10	UniProtKB/TrEMBL
	2.130.10.10	UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/TrEMBL
InterPro	ARM-type_fold	UniProtKB/TrEMBL
	Clathrin_H-chain/VPS_repeat	UniProtKB/TrEMBL
	TPR-like_helical_dom_sf	UniProtKB/TrEMBL
	VPS11	UniProtKB/TrEMBL
	VPS11_C	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
	Znf_RING	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
KEGG Report	ssc:100517049	UniProtKB/TrEMBL
NCBI Gene	VPS11	ENTREZGENE
PANTHER	PTHR23323:SF24	UniProtKB/TrEMBL
Pfam	Clathrin	UniProtKB/TrEMBL
	VPS11_C	UniProtKB/TrEMBL
PIRSF	VPS11	UniProtKB/TrEMBL
PROSITE	CHCR	UniProtKB/TrEMBL
	ZF_RING_2	UniProtKB/TrEMBL
SMART	RING	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48371	UniProtKB/TrEMBL
	SSF50978	UniProtKB/TrEMBL
UniProt	A0A4X1SIU4_PIG	UniProtKB/TrEMBL
	F1SAH7	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:94837	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM