| 631410 | Vac14 | VAC14 component of PIKFYVE complex | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process (ortholog); regulation of postsynaptic neurotransmitter receptor internalization (ortholog); PARTICIPATES IN inositol metabolic pathway; phosphoinositid e metabolic pathway; ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); myoepithelioma (ortholog); FOUND IN endosome membrane (ortholog); presynaptic endosome (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,6-dinitrotoluene | 19 | 55499962 | 55601290 | Rat | 98 | symbol , old_gene_name , PhenoGen , name , ensembl_full_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1347283 | VAC14 | VAC14 component of PIKFYVE complex | This gene encodes a scaffold protein that is a component of the PIKfyve protein kinase complex. This complex is responsible for the synthesis of phosphatidylinositol 3,5-bisphosphate, an important component of cellular membranes, from phosphatidylinositol 3-phosphate. Mice lacking a functional copy of this gene exhibit severe neurodegeneration. Mutations in the human gene have been identified in patients with a childhood onset progressive neurological disorder characterized by impaired movement, dystonia, and striatal abnormalities. [provided by RefSeq, May 2017] | 16 | 70687439 | 70801158 | Human | 275 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1551146 | Vac14 | Vac14 homolog (S. cerevisiae) | Predicted to enable identical protein binding activity and kinase activator activity. Involved in regulation of postsynaptic neurotransmitter receptor internalization. Is active in presynaptic endosome. Is expressed in cerebral cortex ventricular layer; cortical plate; embryo; and extraembryonic com ponent. Human ortholog(s) of this gene implicated in striatonigral degeneration. Orthologous to human VAC14 (VAC14 component of PIKFYVE complex). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 111345161 | 111447030 | Mouse | 146 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8841362 | Vac14 | VAC14 component of PIKFYVE complex | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process (ortholog); regulation of postsynaptic neurotransmitter receptor internalization (ortholog); PARTICIPATES IN inositol metabolic pathway; phosphoinositid e metabolic pathway; ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); myoepithelioma (ortholog); FOUND IN endosome membrane (ortholog); presynaptic endosome (ortholog) | NW_004955484 | 3451187 | 3557471 | Chinchilla | 24 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12044322 | VAC14 | VAC14 component of PIKFYVE complex | ENCODES a protein that exhibits identical protein binding (inferred); INVOLVED IN 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process (inferred); phosphatidylinositol biosynthetic process (inferred); regulation of postsynaptic neurotransmitter receptor internalization (inferred); PARTI CIPATES IN inositol metabolic pathway; phosphoinositide metabolic pathway; ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); myoepithelioma (ortholog); FOUND IN endosome (inferred); endosome membrane (inferred); PAS complex (inferred) | 16 | 54216303 | 54330073 | Bonobo | 31 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12184399 | VAC14 | VAC14 component of PIKFYVE complex | ENCODES a protein that exhibits identical protein binding (inferred); INVOLVED IN 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process (inferred); phosphatidylinositol biosynthetic process (inferred); regulation of postsynaptic neurotransmitter receptor internalization (inferred); PARTI CIPATES IN inositol metabolic pathway; phosphoinositide metabolic pathway; ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); myoepithelioma (ortholog); FOUND IN endosome (inferred); endosome membrane (inferred); PAS complex (inferred) | 5 | 76635931 | 76737414 | Dog | 31 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12567341 | Vac14 | VAC14 component of PIKFYVE complex | ENCODES a protein that exhibits identical protein binding (inferred); INVOLVED IN 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process (inferred); phosphatidylinositol biosynthetic process (inferred); regulation of postsynaptic neurotransmitter receptor internalization (inferred); PARTI CIPATES IN inositol metabolic pathway; phosphoinositide metabolic pathway; ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); myoepithelioma (ortholog); FOUND IN endosome (inferred); endosome membrane (inferred); PAS complex (inferred) | NW_004936475 | 22842333 | 22944680 | Squirrel | 31 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18486444 | VAC14 | VAC14 component of PIKFYVE complex | ENCODES a protein that exhibits identical protein binding (inferred); INVOLVED IN 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process (inferred); phosphatidylinositol biosynthetic process (inferred); regulation of postsynaptic neurotransmitter receptor internalization (inferred); PARTI CIPATES IN inositol metabolic pathway; phosphoinositide metabolic pathway; ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); myoepithelioma (ortholog); FOUND IN endosome (inferred); endosome membrane (inferred); PAS complex (inferred) | | | | Green Monkey | 31 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155238616 | vac14 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18908504 | Vac14 | VAC14 component of PIKFYVE complex | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process (ortholog); regulation of postsynaptic neurotransmitter receptor internalization (ortholog); PARTICIPATES IN inositol metabolic pathway; phosphoinositid e metabolic pathway; ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); myoepithelioma (ortholog); FOUND IN presynaptic endosome (ortholog) | | | | Naked Mole-Rat | 30 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14387816 | VAC14 | | | | | | Yeast | | symbol | gene, null |
| 14263403 | VAC14 | VAC14 component of PIKFYVE complex | ENCODES a protein that exhibits identical protein binding (inferred); INVOLVED IN 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process (inferred); phosphatidylinositol biosynthetic process (inferred); regulation of postsynaptic neurotransmitter receptor internalization (inferred); PARTI CIPATES IN inositol metabolic pathway; phosphoinositide metabolic pathway; ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); myoepithelioma (ortholog); FOUND IN endomembrane system (inferred); endosome (inferred); endosome membrane (inferred) | | | | Pig | 32 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 625900719 | Vac14 | VAC14 component of PIKFYVE complex | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process (ortholog); regulation of postsynaptic neurotransmitter receptor internalization (ortholog); PARTICIPATES IN inositol metabolic pathway; phosphoinositid e metabolic pathway; ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); myoepithelioma (ortholog); FOUND IN endosome membrane (ortholog); presynaptic endosome (ortholog) | | | | Black Rat | 24 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155238617 | vac14.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 7244455 | VAC14-AS1 | VAC14 antisense RNA 1 | INTERACTS WITH beta-lapachone; bisphenol A; DDE | 16 | 70755095 | 70773251 | Human | 5 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 617154639 | VAC14-AS2 | VAC14 antisense RNA 2 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna |
| 16561521 | AL122126.1 | Vac14 homolog (S. cerevisiae) (VAC14) pseudogene | | 14 | 28857384 | 28858701 | Human | | old_gene_name , name | gene, pseudo, INFERRED [RefSeq] |
| 14053171 | LOC102168126 | protein VAC14 homolog | | | | | Pig | | name | gene, protein-coding, MODEL [RefSeq] |
| 16562602 | AC020763.1 | novel transcript, antisense to VAC14 | | | | | Human | | name | gene, lncrna |
