VAC14 (VAC14 component of PIKFYVE complex) - Rat Genome Database

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Gene: VAC14 (VAC14 component of PIKFYVE complex) Sus scrofa
Analyze
Symbol: VAC14
Name: VAC14 component of PIKFYVE complex
RGD ID: 14263403
Description: ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN regulation of postsynaptic neurotransmitter receptor internalization (ortholog); PARTICIPATES IN inositol metabolic pathway; phosphoinositide metabolic pathway; ASSOCIATED WITH autosomal dominant dyskeratosis congenita 6 (ortholog); genetic disease (ortholog); myoepithelioma (ortholog); FOUND IN cytosol (ortholog); presynaptic endosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein VAC14 homolog; Vac14 homolog; Vac14, PIKFYVE complex component; Vac14-like protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl613,683,801 - 13,791,241 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1613,683,800 - 13,791,246 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2613,797,010 - 13,819,469 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:30032202  


Genomics

Comparative Map Data
VAC14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl613,683,801 - 13,791,241 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1613,683,800 - 13,791,246 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2613,797,010 - 13,819,469 (+)NCBISscrofa10.2Sscrofa10.2susScr3
VAC14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381670,687,439 - 70,801,158 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1670,687,439 - 70,801,160 (-)EnsemblGRCh38hg38GRCh38
GRCh371670,721,342 - 70,835,061 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361669,278,843 - 69,392,562 (-)NCBINCBI36Build 36hg18NCBI36
Build 341669,278,844 - 69,392,562NCBI
Celera1654,687,481 - 54,803,215 (+)NCBICelera
Cytogenetic Map16q22.1-q22.2NCBI
HuRef1656,552,837 - 56,666,566 (-)NCBIHuRef
CHM1_11672,128,694 - 72,242,416 (-)NCBICHM1_1
T2T-CHM13v2.01676,498,610 - 76,612,330 (-)NCBIT2T-CHM13v2.0
Vac14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398111,345,161 - 111,447,030 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8111,345,217 - 111,447,030 (+)EnsemblGRCm39 Ensembl
GRCm388110,618,529 - 110,720,398 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8110,618,585 - 110,720,398 (+)EnsemblGRCm38mm10GRCm38
MGSCv378113,142,538 - 113,244,298 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368113,505,315 - 113,607,075 (+)NCBIMGSCv36mm8
Celera8114,842,345 - 114,944,148 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map857.59NCBI
Vac14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81955,499,962 - 55,601,290 (+)NCBIGRCr8
mRatBN7.21938,590,569 - 38,691,911 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1938,590,569 - 38,691,909 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1945,396,503 - 45,497,671 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01946,049,874 - 46,151,038 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01948,360,269 - 48,461,568 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01940,927,007 - 41,029,206 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1940,927,007 - 41,029,206 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01951,753,772 - 51,855,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41940,538,392 - 40,639,758 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11940,543,272 - 40,644,637 (+)NCBI
Celera1937,985,831 - 38,087,096 (+)NCBICelera
Cytogenetic Map19q12NCBI
Vac14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554843,451,016 - 3,557,824 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554843,451,187 - 3,557,471 (-)NCBIChiLan1.0ChiLan1.0
VAC14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21883,365,110 - 83,478,896 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11689,298,744 - 89,412,522 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01654,216,303 - 54,330,073 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11670,520,440 - 70,634,152 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1670,520,440 - 70,634,143 (-)Ensemblpanpan1.1panPan2
VAC14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1576,635,931 - 76,737,414 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl576,636,355 - 76,737,353 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha576,596,687 - 76,696,623 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0577,072,565 - 77,173,409 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl577,072,570 - 77,173,703 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1576,894,317 - 76,995,070 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0576,716,769 - 76,817,393 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0577,208,877 - 77,309,628 (-)NCBIUU_Cfam_GSD_1.0
Vac14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934936,644,434 - 36,746,811 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647522,842,248 - 22,944,690 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647522,842,333 - 22,944,680 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VAC14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1553,829,168 - 53,944,178 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl553,828,117 - 53,944,136 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604716,641,321 - 16,756,343 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vac14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474612,888,208 - 12,992,397 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474612,889,010 - 12,992,318 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in VAC14
3360 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 1 2
Low 10 4 3 4 2 22 2 3 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000003024   ⟹   ENSSSCP00000002945
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl613,683,801 - 13,791,241 (-)Ensembl
RefSeq Acc Id: XM_021093808   ⟹   XP_020949467
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1613,683,800 - 13,791,246 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020949467 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000002945
  ENSSSCP00000002945.3
  ENSSSCP00005025216.1
  ENSSSCP00005025229.1
  ENSSSCP00030030766.1
  ENSSSCP00030030799.1
  ENSSSCP00065038953.1
  ENSSSCP00070003984.1
GenBank Protein JAA74101 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_020949467   ⟸   XM_021093808
- UniProtKB: M3TYF6 (UniProtKB/TrEMBL),   F1S3E8 (UniProtKB/TrEMBL),   A0A480XXH2 (UniProtKB/TrEMBL),   A0A4X1SNQ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000002945   ⟸   ENSSSCT00000003024
Protein Domains
Vacuolar protein 14 C-terminal Fig4-binding


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000002729 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005025992 UniProtKB/TrEMBL
  ENSSSCG00030048122 UniProtKB/TrEMBL
  ENSSSCG00065064921 UniProtKB/TrEMBL
  ENSSSCG00070002620 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000003024 ENTREZGENE
  ENSSSCT00000003024.5 UniProtKB/TrEMBL
  ENSSSCT00005041239.1 UniProtKB/TrEMBL
  ENSSSCT00005041265.1 UniProtKB/TrEMBL
  ENSSSCT00030067173.1 UniProtKB/TrEMBL
  ENSSSCT00030067240.1 UniProtKB/TrEMBL
  ENSSSCT00065089101.1 UniProtKB/TrEMBL
  ENSSSCT00070004893.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Vac14 UniProtKB/TrEMBL
  VAC14_Fig4p-bd UniProtKB/TrEMBL
NCBI Gene VAC14 ENTREZGENE
PANTHER PROTEIN VAC14 HOMOLOG UniProtKB/TrEMBL
  PTHR16023 UniProtKB/TrEMBL
Pfam Vac14_Fab1_bd UniProtKB/TrEMBL
  Vac14_Fig4_bd UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
UniProt A0A480XXH2 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SNQ9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0J923_PIG UniProtKB/TrEMBL
  A0A8D0LPB1_PIG UniProtKB/TrEMBL
  A0A8D1ZPR2_PIG UniProtKB/TrEMBL
  F1S3E8 ENTREZGENE, UniProtKB/TrEMBL
  M3TYF6 ENTREZGENE
UniProt Secondary M3TYF6 UniProtKB/TrEMBL
VGNC ID VGNC:98405 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-23 VAC14  VAC14 component of PIKFYVE complex    Vac14, PIKFYVE complex component  Symbol and/or name change 5135510 APPROVED