| 1310354 | Usp22 | ubiquitin specific peptidase 22 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); enzyme binding (ortholog); histone H2A deubiquitinase activity (ortholog); INVOLVED IN G2/M transition of mitotic cell cycle (ortholog); positive regulation of DNA-templated transcription (ortholog); positive regulatio n of mitotic cell cycle (ortholog); PARTICIPATES IN histone modification pathway; RNA polymerase II transcription initiation pathway; FOUND IN SAGA complex (ortholog); INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil; acetamide | 10 | 46328092 | 46354939 | Rat | 84 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1321210 | USP22 | ubiquitin specific peptidase 22 | Enables deubiquitinase activity; enzyme binding activity; and transcription coactivator activity. Contributes to histone H4 acetyltransferase activity. Involved in several processes, including G2/M transition of mitotic cell cycle; protein deubiquitination; and regulation of gene expression. Part of SAGA complex. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 20999596 | 21043419 | Human | 99 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1321211 | Usp22 | ubiquitin specific peptidase 22 | Enables cysteine-type deubiquitinase activity. Acts upstream of or within protein deubiquitination. Predicted to be located in cytoplasm. Predicted to be part of SAGA complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and resp iratory system. Orthologous to human USP22 (ubiquitin specific peptidase 22). [provided by Alliance of Genome Resources, Apr 2025] | 11 | 61042607 | 61065885 | Mouse | 143 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8864314 | Usp22 | ubiquitin specific peptidase 22 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); enzyme binding (ortholog); histone H2A deubiquitinase activity (ortholog); INVOLVED IN G2/M transition of mitotic cell cycle (ortholog); positive regulation of DNA-templated transcription (ortholog); positive regulatio n of mitotic cell cycle (ortholog); PARTICIPATES IN histone modification pathway; RNA polymerase II transcription initiation pathway; FOUND IN SAGA complex (ortholog) | NW_004955577 | 979317 | 1002478 | Chinchilla | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11744836 | USP22 | ubiquitin specific peptidase 22 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN protein deubiquitination (ortholog); PARTICIPATES IN histone modification pathway; RNA polymerase II transcription initiation pathway; FOUND IN nucleus (inferred); SAGA complex (inferred) | 17 | 30606845 | 30650281 | Bonobo | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12400467 | USP22 | ubiquitin specific peptidase 22 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); enzyme binding (ortholog); histone H2A deubiquitinase activity (ortholog); INVOLVED IN G2/M transition of mitotic cell cycle (ortholog); positive regulation of DNA-templated transcription (ortholog); positive regulatio n of mitotic cell cycle (ortholog); PARTICIPATES IN histone modification pathway; RNA polymerase II transcription initiation pathway; FOUND IN SAGA complex (ortholog) | 5 | 42493776 | 42519740 | Dog | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12727364 | Usp22 | ubiquitin specific peptidase 22 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN protein deubiquitination (ortholog); PARTICIPATES IN histone modification pathway; RNA polymerase II transcription initiation pathway; FOUND IN SAGA complex (inferred) | NW_004936741 | 580230 | 618322 | Squirrel | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14285140 | USP22 | ubiquitin specific peptidase 22 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN protein deubiquitination (ortholog); PARTICIPATES IN histone modification pathway; RNA polymerase II transcription initiation pathway; FOUND IN SAGA complex (inferred) | | | | Pig | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18519571 | USP22 | ubiquitin specific peptidase 22 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); INVOLVED IN protein deubiquitination (ortholog); PARTICIPATES IN histone modification pathway; RNA polymerase II transcription initiation pathway; FOUND IN SAGA complex (inferred) | | | | Green Monkey | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247936 | usp22 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18903576 | Usp22 | ubiquitin specific peptidase 22 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); enzyme binding (ortholog); histone H2A deubiquitinase activity (ortholog); INVOLVED IN G2/M transition of mitotic cell cycle (ortholog); positive regulation of DNA-templated transcription (ortholog); positive regulatio n of mitotic cell cycle (ortholog); PARTICIPATES IN histone modification pathway; RNA polymerase II transcription initiation pathway; FOUND IN SAGA complex (ortholog) | | | | Naked Mole-Rat | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155231929 | usp22.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155257446 | usp22.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16563833 | AC087393.2 | novel transcript, antisense to USP22 | | | | | Human | | name | gene, lncrna |
| 16555911 | AC004129.2 | ubiquitin specific peptidase 22 (USP22) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16553039 | AC007312.1 | pseudogene similar to part of ubiquitin specific peptidase 22 (USP22) | | | | | Human | | name | gene, processed_pseudogene |
| 1350698 | USP27X | ubiquitin specific peptidase 27 X-linked | This gene encodes a member of the peptidase protein family. The encoded protein functions as a deubiquitinase that is involved in upregulation of the pro-apoptotic Bim protein. This protein may act as a tumor suppressor by increasing levels of Bim to counteract anti-apoptotic signals in cancer cells . Mutations in this gene have been associated with X-linked cognitive disability. [provided by RefSeq, Dec 2016] | X | 49879484 | 49882558 | Human | 86 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |