| 3850 | Tsc22d1 | TSC22 domain family, member 1 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; identical protein binding (ortholog); INVOLVED IN positive regulation of transcription by RNA polymerase II; negative regul ation of apoptotic process (ortholog); negative regulation of hematopoietic stem cell proliferation (ortholog); ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (ortholog); mitochondrion (ortholog); nucleus (ortholog); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol | 15 | 58159612 | 58260244 | Rat | 302 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1604401 | TSC22D1 | TSC22 domain family member 1 | This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011] | 13 | 44432143 | 44577344 | Human | 293 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1615941 | Tsc22d1 | TSC22 domain family, member 1 | Predicted to enable identical protein binding activity and transcription coactivator activity. Involved in negative regulation of hematopoietic stem cell proliferation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early co nceptus; genitourinary system; and sensory organ. Orthologous to human TSC22D1 (TSC22 domain family member 1). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 76652401 | 76745205 | Mouse | 289 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8777023 | Tsc22d1 | TSC22 domain family member 1 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); identical protein binding (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog) ; negative regulation of hematopoietic stem cell proliferation (ortholog); negative regulation of programmed cell death (ortholog); ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (ortholog); mitochondrion (ortholog); nucleus (ortholog) | NW_004955518 | 2322566 | 2451519 | Chinchilla | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11883572 | TSC22D1 | TSC22 domain family member 1 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of hematopoietic stem cell proliferation (ortholog); negative regulation of programmed cell death (ortholog); ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN mitochondrion (ortholog) | 13 | 25597530 | 25743522 | Bonobo | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12309873 | TSC22D1 | TSC22 domain family member 1 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of hematopoietic stem cell proliferation (ortholog); negative regulation of programmed cell death (ortholog); ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN mitochondrion (ortholog); INTERACTS WITH bisphenol A | 22 | 6375585 | 6506511 | Dog | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12555685 | Tsc22d1 | TSC22 domain family member 1 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of hematopoietic stem cell proliferation (ortholog); negative regulation of programmed cell death (ortholog); ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN mitochondrion (ortholog) | NW_004936791 | 697244 | 811463 | Squirrel | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18920936 | Tsc22d1 | TSC22 domain family member 1 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); identical protein binding (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog) ; negative regulation of hematopoietic stem cell proliferation (ortholog); negative regulation of programmed cell death (ortholog); ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN mitochondrion (ortholog); plasma membrane (ortholog) | | | | Naked Mole-Rat | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18707332 | TSC22D1 | TSC22 domain family member 1 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of hematopoietic stem cell proliferation (ortholog); negative regulation of programmed cell death (ortholog); ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN mitochondrion (ortholog) | | | | Green Monkey | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626047277 | Tsc22d1 | TSC22 domain family member 1 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); identical protein binding (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog) ; negative regulation of hematopoietic stem cell proliferation (ortholog); negative regulation of programmed cell death (ortholog); ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (ortholog); mitochondrion (ortholog); nucleus (ortholog) | | | | Black Rat | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284317183 | tsc22d1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 20867398 | TSC22D1 | TSC22 domain family member 1 | | | | | Green Monkey | | symbol | gene, protein-coding |
| 13848499 | TSC22D1 | TSC22 domain family member 1 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); identical protein binding (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog) ; negative regulation of hematopoietic stem cell proliferation (ortholog); negative regulation of programmed cell death (ortholog); ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN mitochondrion (ortholog); plasma membrane (ortholog); INTERACTS WITH deoxynivalenol; graphene oxide | | | | Pig | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 285747924 | tsc22d1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860132 | tsc22d1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857750 | tsc22d1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859048 | tsc22d1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626173991 | tsc22d1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626180779 | tsc22d1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858430 | tsc22d1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 5687462 | TSC22D1-AS1 | TSC22D1 antisense RNA 1 | INTERACTS WITH (+)-catechin; antirheumatic drug; bisphenol A | 13 | 44575896 | 44580432 | Human | 9 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |