| 1305331 | Tpst2 | tyrosylprotein sulfotransferase 2 | ENCODES a protein that exhibits protein homodimerization activity (ortholog); protein-tyrosine sulfotransferase activity (ortholog); INVOLVED IN fusion of sperm to egg plasma membrane involved in single fertilization (ortholog); peptidyl-tyrosine sulfation (ortholog); prevention of polyspermy (ortho log); ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN endoplasmic reticulum (ortholog); Golgi lumen (ortholog); trans-Golgi network (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; 6-propyl-2-thiouracil | 12 | 49982281 | 50024489 | Rat | 103 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1313297 | TPST2 | tyrosylprotein sulfotransferase 2 | The protein encoded by this gene catalyzes the O-sulfation of tyrosine residues within acidic regions of proteins. The encoded protein is a type II integral membrane protein found in the Golgi body. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by R efSeq, May 2018] | 22 | 26521996 | 26590132 | Human | 102 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1313298 | Tpst2 | protein-tyrosine sulfotransferase 2 | Enables protein-tyrosine sulfotransferase activity. Involved in peptidyl-tyrosine sulfation. Acts upstream of or within fusion of sperm to egg plasma membrane involved in single fertilization and prevention of polyspermy. Is active in Golgi lumen and trans-Golgi network. Orthologous to human TPST2 tyle='font-weight:700;'>TPST2 (tyrosylprotein sulfotransferase 2). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 112424548 | 112463222 | Mouse | 119 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9061651 | Tpst2 | tyrosylprotein sulfotransferase 2 | ENCODES a protein that exhibits protein homodimerization activity (ortholog); protein-tyrosine sulfotransferase activity (ortholog); INVOLVED IN fusion of sperm to egg plasma membrane involved in single fertilization (ortholog); peptidyl-tyrosine sulfation (ortholog); prevention of polyspermy (ortho log); ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN endoplasmic reticulum (ortholog); Golgi lumen (ortholog); trans-Golgi network (ortholog) | NW_004955455 | 1106403 | 1128455 | Chinchilla | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11697230 | TPST2 | tyrosylprotein sulfotransferase 2 | ENCODES a protein that exhibits protein homodimerization activity (inferred); protein-tyrosine sulfotransferase activity (inferred); sulfotransferase activity (inferred); INVOLVED IN fusion of sperm to egg plasma membrane involved in single fertilization (ortholog); peptidyl-tyrosine sulfation (orth olog); prevention of polyspermy (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN endoplasmic reticulum (inferred); Golgi apparatus (inferred); Golgi lumen (inferred) | 22 | 7587446 | 7651645 | Bonobo | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12173142 | TPST2 | tyrosylprotein sulfotransferase 2 | ENCODES a protein that exhibits protein homodimerization activity (ortholog); INVOLVED IN fusion of sperm to egg plasma membrane involved in single fertilization (ortholog); peptidyl-tyrosine sulfation (ortholog); prevention of polyspermy (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholo g); FOUND IN endoplasmic reticulum (ortholog); Golgi lumen (ortholog); trans-Golgi network (ortholog) | 26 | 20199731 | 20240084 | Dog | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12652417 | Tpst2 | tyrosylprotein sulfotransferase 2 | ENCODES a protein that exhibits protein homodimerization activity (inferred); protein-tyrosine sulfotransferase activity (inferred); sulfotransferase activity (inferred); INVOLVED IN fusion of sperm to egg plasma membrane involved in single fertilization (ortholog); peptidyl-tyrosine sulfation (orth olog); prevention of polyspermy (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN endoplasmic reticulum (inferred); Golgi apparatus (inferred); Golgi lumen (inferred) | NW_004936657 | 1144526 | 1157501 | Squirrel | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18922733 | Tpst2 | tyrosylprotein sulfotransferase 2 | ENCODES a protein that exhibits protein homodimerization activity (ortholog); INVOLVED IN fusion of sperm to egg plasma membrane involved in single fertilization (ortholog); peptidyl-tyrosine sulfation (ortholog); prevention of polyspermy (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholo g); FOUND IN endoplasmic reticulum (ortholog); Golgi lumen (ortholog); trans-Golgi network (ortholog) | | | | Naked Mole-Rat | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626072232 | Tpst2 | tyrosylprotein sulfotransferase 2 | ENCODES a protein that exhibits protein homodimerization activity (ortholog); protein-tyrosine sulfotransferase activity (ortholog); INVOLVED IN fusion of sperm to egg plasma membrane involved in single fertilization (ortholog); peptidyl-tyrosine sulfation (ortholog); prevention of polyspermy (ortho log); ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN endoplasmic reticulum (ortholog); Golgi lumen (ortholog); trans-Golgi network (ortholog) | | | | Black Rat | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13869106 | TPST2 | tyrosylprotein sulfotransferase 2 | ENCODES a protein that exhibits protein homodimerization activity (ortholog); INVOLVED IN fusion of sperm to egg plasma membrane involved in single fertilization (ortholog); peptidyl-tyrosine sulfation (ortholog); prevention of polyspermy (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholo g); FOUND IN endoplasmic reticulum (ortholog); Golgi lumen (ortholog); trans-Golgi network (ortholog) | | | | Pig | 19 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 155239979 | tpst2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18721652 | TPST2 | tyrosylprotein sulfotransferase 2 | ENCODES a protein that exhibits protein homodimerization activity (inferred); protein-tyrosine sulfotransferase activity (inferred); sulfotransferase activity (inferred); INVOLVED IN fusion of sperm to egg plasma membrane involved in single fertilization (ortholog); peptidyl-tyrosine sulfation (orth olog); prevention of polyspermy (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN endoplasmic reticulum (inferred); Golgi apparatus (inferred); Golgi lumen (inferred) | | | | Green Monkey | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155239980 | tpst2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155239326 | tpst2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 6904327 | TPST2P1 | tyrosylprotein sulfotransferase 2 pseudogene 1 | | 15 | 36626677 | 36627776 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |