TPST2 (tyrosylprotein sulfotransferase 2) - Rat Genome Database

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Gene: TPST2 (tyrosylprotein sulfotransferase 2) Homo sapiens
Analyze
Symbol: TPST2
Name: tyrosylprotein sulfotransferase 2
RGD ID: 1313297
HGNC Page HGNC:12021
Description: Enables protein homodimerization activity and protein-tyrosine sulfotransferase activity. Involved in peptidyl-tyrosine sulfation. Located in endoplasmic reticulum.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: protein-tyrosine sulfotransferase 2; TANGO13B; TPST-2; transport and golgi organization 13 homolog B; tyrosylprotein phosphotransferase 2; tyrosylprotein sulfotransferase-2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: TPST2P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382226,521,996 - 26,590,132 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2226,521,996 - 26,596,717 (-)EnsemblGRCh38hg38GRCh38
GRCh372226,917,962 - 26,986,096 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362225,251,714 - 25,316,089 (-)NCBINCBI36Build 36hg18NCBI36
Build 342225,246,269 - 25,310,643NCBI
Celera2210,725,568 - 10,789,890 (-)NCBICelera
Cytogenetic Map22q12.1NCBI
HuRef229,869,106 - 9,933,721 (-)NCBIHuRef
CHM1_12226,880,965 - 26,945,609 (-)NCBICHM1_1
T2T-CHM13v2.02226,984,404 - 27,052,464 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9733778   PMID:9736702   PMID:10089882   PMID:10497246   PMID:10591208   PMID:11230166   PMID:11256614   PMID:12056800   PMID:12169668   PMID:12477932   PMID:14702039   PMID:15461802  
PMID:15489334   PMID:16303743   PMID:17558413   PMID:18672380   PMID:19343046   PMID:19402700   PMID:20460947   PMID:21873635   PMID:23376485   PMID:23481380   PMID:24569807   PMID:26108987  
PMID:26186194   PMID:28514442   PMID:28821720   PMID:32287057   PMID:32393512   PMID:33951064   PMID:33961781   PMID:34473204   PMID:35420441   PMID:35696571   PMID:35748872  


Genomics

Comparative Map Data
TPST2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382226,521,996 - 26,590,132 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2226,521,996 - 26,596,717 (-)EnsemblGRCh38hg38GRCh38
GRCh372226,917,962 - 26,986,096 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362225,251,714 - 25,316,089 (-)NCBINCBI36Build 36hg18NCBI36
Build 342225,246,269 - 25,310,643NCBI
Celera2210,725,568 - 10,789,890 (-)NCBICelera
Cytogenetic Map22q12.1NCBI
HuRef229,869,106 - 9,933,721 (-)NCBIHuRef
CHM1_12226,880,965 - 26,945,609 (-)NCBICHM1_1
T2T-CHM13v2.02226,984,404 - 27,052,464 (-)NCBIT2T-CHM13v2.0
Tpst2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395112,424,548 - 112,463,222 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5112,424,557 - 112,463,227 (+)EnsemblGRCm39 Ensembl
GRCm385112,276,682 - 112,315,356 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5112,276,691 - 112,315,361 (+)EnsemblGRCm38mm10GRCm38
MGSCv375112,705,727 - 112,744,376 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365112,517,029 - 112,555,659 (+)NCBIMGSCv36mm8
Celera5109,396,281 - 109,435,190 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map554.65NCBI
Tpst2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81249,982,281 - 50,024,489 (-)NCBIGRCr8
mRatBN7.21244,321,875 - 44,363,892 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1244,321,875 - 44,362,329 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1245,490,785 - 45,531,171 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01246,101,129 - 46,141,600 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01245,161,667 - 45,202,131 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01250,343,076 - 50,383,534 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1250,343,086 - 50,383,496 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01252,099,677 - 52,141,423 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41914,283,684 - 14,297,517 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11914,290,594 - 14,302,342 (+)NCBI
Celera1245,904,930 - 45,945,380 (-)NCBICelera
Cytogenetic Map12q16NCBI
Tpst2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554551,106,294 - 1,129,196 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554551,106,403 - 1,128,455 (-)NCBIChiLan1.0ChiLan1.0
TPST2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22336,531,196 - 36,595,395 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12239,229,633 - 39,293,863 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0227,587,446 - 7,651,645 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12225,309,254 - 25,334,638 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2225,309,254 - 25,334,638 (-)Ensemblpanpan1.1panPan2
TPST2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12620,199,731 - 20,240,084 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2620,199,754 - 20,212,869 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2620,063,735 - 20,115,947 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02620,563,110 - 20,615,356 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2620,563,112 - 20,615,982 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12620,296,215 - 20,336,928 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02620,535,592 - 20,587,560 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02620,605,612 - 20,657,891 (-)NCBIUU_Cfam_GSD_1.0
Tpst2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118114,713,206 - 114,726,168 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366571,144,292 - 1,157,507 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366571,144,526 - 1,157,501 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPST2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1444,122,159 - 44,145,822 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11444,122,156 - 44,140,654 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21447,001,956 - 47,066,378 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TPST2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1199,427,529 - 9,490,992 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl199,426,162 - 9,446,863 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045116,611,623 - 116,675,737 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tpst2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247473,065,098 - 3,083,279 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247473,065,217 - 3,118,526 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TPST2
27 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 22q11.21-12.3(chr22:18178957-31821193)x3 copy number gain See cases [RCV000050768] Chr22:18178957..31821193 [GRCh38]
Chr22:18661724..32217179 [GRCh37]
Chr22:17041724..30547179 [NCBI36]
Chr22:22q11.21-12.3
pathogenic
GRCh38/hg38 22q12.1-12.2(chr22:26221273-29477543)x1 copy number loss See cases [RCV000052869] Chr22:26221273..29477543 [GRCh38]
Chr22:26617239..29873532 [GRCh37]
Chr22:24947239..28203532 [NCBI36]
Chr22:22q12.1-12.2
pathogenic
GRCh38/hg38 22q11.1-13.33(chr22:16916608-50739836)x3 copy number gain See cases [RCV000133646] Chr22:16916608..50739836 [GRCh38]
Chr22:17397498..51178264 [GRCh37]
Chr22:15777498..49525130 [NCBI36]
Chr22:22q11.1-13.33
pathogenic
GRCh38/hg38 22q11.1-13.33(chr22:16916743-50739785)x3 copy number gain See cases [RCV000134730] Chr22:16916743..50739785 [GRCh38]
Chr22:17397633..51178213 [GRCh37]
Chr22:15777633..49525079 [NCBI36]
Chr22:22q11.1-13.33
pathogenic
GRCh38/hg38 22q11.23-12.1(chr22:25003092-28634004)x1 copy number loss See cases [RCV000134954] Chr22:25003092..28634004 [GRCh38]
Chr22:25399059..29029992 [GRCh37]
Chr22:23729059..27359992 [NCBI36]
Chr22:22q11.23-12.1
likely pathogenic
GRCh38/hg38 22q12.1(chr22:25685148-28217405)x1 copy number loss See cases [RCV000136530] Chr22:25685148..28217405 [GRCh38]
Chr22:26081115..28613393 [GRCh37]
Chr22:24411115..26943393 [NCBI36]
Chr22:22q12.1
uncertain significance
GRCh38/hg38 22q11.23-12.3(chr22:23279231-36247369)x3 copy number gain See cases [RCV000138172] Chr22:23279231..36247369 [GRCh38]
Chr22:23621418..36643415 [GRCh37]
Chr22:21951418..34973361 [NCBI36]
Chr22:22q11.23-12.3
pathogenic
GRCh38/hg38 22q11.21-12.3(chr22:20907226-37187347)x3 copy number gain See cases [RCV000137926] Chr22:20907226..37187347 [GRCh38]
Chr22:21261514..37583387 [GRCh37]
Chr22:19591514..35913333 [NCBI36]
Chr22:22q11.21-12.3
pathogenic
GRCh38/hg38 22q12.1(chr22:26535859-27296063)x1 copy number loss See cases [RCV000139801] Chr22:26535859..27296063 [GRCh38]
Chr22:26931825..27692024 [GRCh37]
Chr22:25261825..26022024 [NCBI36]
Chr22:22q12.1
uncertain significance
GRCh38/hg38 22q12.1-12.2(chr22:26451042-31451926)x1 copy number loss See cases [RCV000143415] Chr22:26451042..31451926 [GRCh38]
Chr22:26847008..31847912 [GRCh37]
Chr22:25177008..30177912 [NCBI36]
Chr22:22q12.1-12.2
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51237518)x3 copy number gain See cases [RCV000240091] Chr22:16054691..51237518 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-12.1(chr22:16054691-27296513)x3 copy number gain See cases [RCV000240348] Chr22:16054691..27296513 [GRCh37]
Chr22:22q11.1-12.1
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51220902)x3 copy number gain See cases [RCV000446956] Chr22:16054691..51220902 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51237463)x3 copy number gain See cases [RCV000448847] Chr22:16054691..51237463 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888900-51197838) copy number gain See cases [RCV000510873] Chr22:16888900..51197838 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.23-12.3(chr22:23637907-36614412)x3 copy number gain See cases [RCV000511098] Chr22:23637907..36614412 [GRCh37]
Chr22:22q11.23-12.3
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888900-51197838)x3 copy number gain See cases [RCV000512333] Chr22:16888900..51197838 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.22-12.3(chr22:22460754-35198232)x3 copy number gain not provided [RCV000684530] Chr22:22460754..35198232 [GRCh37]
Chr22:22q11.22-12.3
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054667-51243435)x3 copy number gain not provided [RCV000741689] Chr22:16054667..51243435 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16114244-51195728)x3 copy number gain not provided [RCV000741691] Chr22:16114244..51195728 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16114244-51211392)x3 copy number gain not provided [RCV000741692] Chr22:16114244..51211392 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
NM_003595.5(TPST2):c.124C>T (p.Arg42Trp) single nucleotide variant not specified [RCV004301883] Chr22:26541507 [GRCh38]
Chr22:26937473 [GRCh37]
Chr22:22q12.1
uncertain significance
GRCh37/hg19 22q11.1-13.33(chr22:16888899-51197838)x3 copy number gain not provided [RCV000846344] Chr22:16888899..51197838 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
NC_000022.10:g.(?_26142492)_(27026451_?)del deletion Cataract 23 [RCV003107531] Chr22:26142492..27026451 [GRCh37]
Chr22:22q12.1
uncertain significance
GRCh37/hg19 22q12.1(chr22:26337910-28489947)x1 copy number loss not provided [RCV001007180] Chr22:26337910..28489947 [GRCh37]
Chr22:22q12.1
pathogenic
GRCh37/hg19 22q11.1-12.1(chr22:16888899-27657507)x3 copy number gain not provided [RCV001007163] Chr22:16888899..27657507 [GRCh37]
Chr22:22q11.1-12.1
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16197005-51224252)x3 copy number gain See cases [RCV001263056] Chr22:16197005..51224252 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q12.1-12.2(chr22:26614429-29847680)x1 copy number loss not provided [RCV002472563] Chr22:26614429..29847680 [GRCh37]
Chr22:22q12.1-12.2
pathogenic
NM_003595.5(TPST2):c.1039C>T (p.Arg347Trp) single nucleotide variant not specified [RCV004222557] Chr22:26536290 [GRCh38]
Chr22:26932256 [GRCh37]
Chr22:22q12.1
uncertain significance
NM_003595.5(TPST2):c.1040G>A (p.Arg347Gln) single nucleotide variant not specified [RCV004223727] Chr22:26536289 [GRCh38]
Chr22:26932255 [GRCh37]
Chr22:22q12.1
uncertain significance
NM_003595.5(TPST2):c.787G>T (p.Ala263Ser) single nucleotide variant not specified [RCV004170646] Chr22:26540844 [GRCh38]
Chr22:26936810 [GRCh37]
Chr22:22q12.1
uncertain significance
NM_003595.5(TPST2):c.739C>T (p.Arg247Cys) single nucleotide variant not specified [RCV004100569] Chr22:26540892 [GRCh38]
Chr22:26936858 [GRCh37]
Chr22:22q12.1
uncertain significance
NM_003595.5(TPST2):c.847G>A (p.Glu283Lys) single nucleotide variant not specified [RCV004129518] Chr22:26536482 [GRCh38]
Chr22:26932448 [GRCh37]
Chr22:22q12.1
uncertain significance
NM_003595.5(TPST2):c.898A>C (p.Lys300Gln) single nucleotide variant not specified [RCV004211311] Chr22:26536431 [GRCh38]
Chr22:26932397 [GRCh37]
Chr22:22q12.1
uncertain significance
NM_003595.5(TPST2):c.890C>T (p.Ala297Val) single nucleotide variant not specified [RCV004179077] Chr22:26536439 [GRCh38]
Chr22:26932405 [GRCh37]
Chr22:22q12.1
uncertain significance
NM_003595.5(TPST2):c.277G>C (p.Glu93Gln) single nucleotide variant not specified [RCV004080366] Chr22:26541354 [GRCh38]
Chr22:26937320 [GRCh37]
Chr22:22q12.1
uncertain significance
NM_003595.5(TPST2):c.130G>A (p.Ala44Thr) single nucleotide variant not specified [RCV004268034] Chr22:26541501 [GRCh38]
Chr22:26937467 [GRCh37]
Chr22:22q12.1
uncertain significance
NM_003595.5(TPST2):c.854C>T (p.Ser285Phe) single nucleotide variant not specified [RCV004261678] Chr22:26536475 [GRCh38]
Chr22:26932441 [GRCh37]
Chr22:22q12.1
uncertain significance
NM_003595.5(TPST2):c.107C>T (p.Ala36Val) single nucleotide variant not specified [RCV004263312] Chr22:26541524 [GRCh38]
Chr22:26937490 [GRCh37]
Chr22:22q12.1
uncertain significance
NM_003595.5(TPST2):c.868A>G (p.Ile290Val) single nucleotide variant not specified [RCV004349297] Chr22:26536461 [GRCh38]
Chr22:26932427 [GRCh37]
Chr22:22q12.1
uncertain significance
NM_003595.5(TPST2):c.73G>A (p.Gly25Arg) single nucleotide variant not specified [RCV004471037] Chr22:26541558 [GRCh38]
Chr22:26937524 [GRCh37]
Chr22:22q12.1
uncertain significance
NM_003595.5(TPST2):c.749A>G (p.Lys250Arg) single nucleotide variant not specified [RCV004471039] Chr22:26540882 [GRCh38]
Chr22:26936848 [GRCh37]
Chr22:22q12.1
uncertain significance
NM_003595.5(TPST2):c.769G>A (p.Gly257Ser) single nucleotide variant not specified [RCV004471040] Chr22:26540862 [GRCh38]
Chr22:26936828 [GRCh37]
Chr22:22q12.1
uncertain significance
NM_003595.5(TPST2):c.989A>T (p.Asn330Ile) single nucleotide variant not specified [RCV004471041] Chr22:26536340 [GRCh38]
Chr22:26932306 [GRCh37]
Chr22:22q12.1
uncertain significance
NM_003595.5(TPST2):c.646A>G (p.Lys216Glu) single nucleotide variant not specified [RCV004471036] Chr22:26540985 [GRCh38]
Chr22:26936951 [GRCh37]
Chr22:22q12.1
uncertain significance
NM_003595.5(TPST2):c.188G>A (p.Arg63His) single nucleotide variant not specified [RCV004677367] Chr22:26541443 [GRCh38]
Chr22:26937409 [GRCh37]
Chr22:22q12.1
uncertain significance
NM_003595.5(TPST2):c.125G>A (p.Arg42Gln) single nucleotide variant not specified [RCV004677368] Chr22:26541506 [GRCh38]
Chr22:26937472 [GRCh37]
Chr22:22q12.1
uncertain significance
NM_003595.5(TPST2):c.5G>A (p.Arg2His) single nucleotide variant not specified [RCV004687612] Chr22:26541626 [GRCh38]
Chr22:26937592 [GRCh37]
Chr22:22q12.1
uncertain significance
NM_003595.5(TPST2):c.512G>A (p.Arg171His) single nucleotide variant not specified [RCV004677370] Chr22:26541119 [GRCh38]
Chr22:26937085 [GRCh37]
Chr22:22q12.1
uncertain significance
NM_003595.5(TPST2):c.1070C>A (p.Ala357Asp) single nucleotide variant not specified [RCV004677371] Chr22:26532717 [GRCh38]
Chr22:26928683 [GRCh37]
Chr22:22q12.1
uncertain significance
NM_003595.5(TPST2):c.302G>T (p.Arg101Leu) single nucleotide variant not specified [RCV004878290] Chr22:26541329 [GRCh38]
Chr22:26937295 [GRCh37]
Chr22:22q12.1
uncertain significance
NM_003595.5(TPST2):c.157G>T (p.Val53Leu) single nucleotide variant not specified [RCV004878291] Chr22:26541474 [GRCh38]
Chr22:26937440 [GRCh37]
Chr22:22q12.1
uncertain significance
NM_003595.5(TPST2):c.377C>T (p.Ala126Val) single nucleotide variant not specified [RCV004878292] Chr22:26541254 [GRCh38]
Chr22:26937220 [GRCh37]
Chr22:22q12.1
uncertain significance
NM_003595.5(TPST2):c.485C>T (p.Thr162Met) single nucleotide variant not specified [RCV004878293] Chr22:26541146 [GRCh38]
Chr22:26937112 [GRCh37]
Chr22:22q12.1
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2281
Count of miRNA genes:784
Interacting mature miRNAs:921
Transcripts:ENST00000338754, ENST00000398110, ENST00000403880, ENST00000440953, ENST00000442495, ENST00000445720, ENST00000450022, ENST00000453117, ENST00000454778
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581529BP71_HBlood pressure QTL 71 (human)20.001Blood pressurepulse pressure221109496637094966Human
597180458GWAS1276532_Hprotein-tyrosine sulfotransferase 2 measurement QTL GWAS1276532 (human)4e-80protein-tyrosine sulfotransferase 2 measurement222652735926527360Human
597022993GWAS1119067_Hantisaccade response measurement QTL GWAS1119067 (human)0.000004antisaccade response measurement222656386026563861Human
2289428BW313_HBody weight QTL 313 (human)2.090.0015Body weightBMI221134428437344284Human
597301196GWAS1397270_Hprotein-tyrosine sulfotransferase 2 measurement QTL GWAS1397270 (human)6e-23protein-tyrosine sulfotransferase 2 measurement222652849026528491Human
597121853GWAS1217927_Hblood protein measurement QTL GWAS1217927 (human)1e-15blood protein amount (VT:0005416)blood protein measurement (CMO:0000028)222652575926525760Human
597340502GWAS1436576_Hneuroticism measurement, cognitive function measurement QTL GWAS1436576 (human)4e-08neuroticism measurement, cognitive function measurement222657119826571199Human
597329140GWAS1425214_Hbody mass index QTL GWAS1425214 (human)2e-09body mass indexbody mass index (BMI) (CMO:0000105)222652575926525760Human
597214471GWAS1310545_Hepisodic memory QTL GWAS1310545 (human)2e-09episodic memory222654525726545258Human

Markers in Region
SHGC-37519  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372226,968,896 - 26,969,020UniSTSGRCh37
Build 362225,298,896 - 25,299,020RGDNCBI36
Celera2210,772,692 - 10,772,816RGD
Cytogenetic Map22q12.1UniSTS
HuRef229,916,554 - 9,916,678UniSTS
Stanford-G3 RH Map22486.0UniSTS
NCBI RH Map22106.3UniSTS
GeneMap99-G3 RH Map22486.0UniSTS
G49193  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372226,921,618 - 26,921,883UniSTSGRCh37
Build 362225,251,618 - 25,251,883RGDNCBI36
Celera2210,725,472 - 10,725,737RGD
Cytogenetic Map22q12.1UniSTS
HuRef229,869,010 - 9,869,275UniSTS
G49244  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372226,943,546 - 26,943,838UniSTSGRCh37
Build 362225,273,546 - 25,273,838RGDNCBI36
Celera2210,747,399 - 10,747,691RGD
Cytogenetic Map22q12.1UniSTS
HuRef229,890,939 - 9,891,231UniSTS
WI-14070  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372226,921,726 - 26,921,875UniSTSGRCh37
Build 362225,251,726 - 25,251,875RGDNCBI36
Celera2210,725,580 - 10,725,729RGD
Cytogenetic Map22q12.1UniSTS
HuRef229,869,118 - 9,869,267UniSTS
GeneMap99-GB4 RH Map2274.62UniSTS
Whitehead-RH Map2263.3UniSTS
NCBI RH Map22105.5UniSTS
WI-19497  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372226,972,517 - 26,972,640UniSTSGRCh37
Build 362225,302,517 - 25,302,640RGDNCBI36
Celera2210,776,314 - 10,776,437RGD
Cytogenetic Map22q12.1UniSTS
HuRef229,920,175 - 9,920,298UniSTS
GeneMap99-GB4 RH Map2274.62UniSTS
Whitehead-RH Map2263.3UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4974 1726 2351 6 624 1951 465 2270 7306 6472 53 3734 1 852 1744 1617 175 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001008566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001362922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001362923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024452294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047441549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_007067981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA531491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF049891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF061254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ006198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK057171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK074538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK093872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL136623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL708491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC001057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC017509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ782485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ783200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR456597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR533528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI573878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI573880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF511430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF511431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z95115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000338754   ⟹   ENSP00000339813
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2226,521,996 - 26,590,132 (-)Ensembl
Ensembl Acc Id: ENST00000398110   ⟹   ENSP00000381180
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2226,525,746 - 26,565,368 (-)Ensembl
Ensembl Acc Id: ENST00000403880   ⟹   ENSP00000385192
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2226,525,746 - 26,596,717 (-)Ensembl
Ensembl Acc Id: ENST00000440953   ⟹   ENSP00000416791
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2226,541,439 - 26,590,125 (-)Ensembl
Ensembl Acc Id: ENST00000442495   ⟹   ENSP00000403875
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2226,541,206 - 26,590,125 (-)Ensembl
Ensembl Acc Id: ENST00000445720   ⟹   ENSP00000403758
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2226,535,895 - 26,540,871 (-)Ensembl
Ensembl Acc Id: ENST00000450022   ⟹   ENSP00000414809
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2226,541,490 - 26,590,125 (-)Ensembl
Ensembl Acc Id: ENST00000453117   ⟹   ENSP00000401134
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2226,541,485 - 26,565,726 (-)Ensembl
Ensembl Acc Id: ENST00000454778   ⟹   ENSP00000400357
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2226,524,082 - 26,550,653 (-)Ensembl
RefSeq Acc Id: NM_001008566   ⟹   NP_001008566
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382226,521,996 - 26,565,341 (-)NCBI
GRCh372226,921,714 - 26,986,089 (-)RGD
Build 362225,251,714 - 25,291,370 (-)NCBI Archive
Celera2210,725,568 - 10,789,890 (-)RGD
HuRef229,869,106 - 9,933,721 (-)RGD
CHM1_12226,880,965 - 26,920,657 (-)NCBI
T2T-CHM13v2.02226,984,404 - 27,027,698 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001362922   ⟹   NP_001349851
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382226,521,996 - 26,590,132 (-)NCBI
T2T-CHM13v2.02226,984,404 - 27,052,464 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001362923   ⟹   NP_001349852
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382226,521,996 - 26,590,132 (-)NCBI
T2T-CHM13v2.02226,984,404 - 27,052,464 (-)NCBI
Sequence:
RefSeq Acc Id: NM_003595   ⟹   NP_003586
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382226,521,996 - 26,590,132 (-)NCBI
GRCh372226,921,714 - 26,986,089 (-)RGD
Build 362225,251,714 - 25,316,089 (-)NCBI Archive
Celera2210,725,568 - 10,789,890 (-)RGD
HuRef229,869,106 - 9,933,721 (-)RGD
CHM1_12226,880,965 - 26,945,609 (-)NCBI
T2T-CHM13v2.02226,984,404 - 27,052,464 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024452294   ⟹   XP_024308062
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382226,521,996 - 26,550,648 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047441549   ⟹   XP_047297505
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382226,521,996 - 26,565,341 (-)NCBI
RefSeq Acc Id: XR_007067981
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382226,521,996 - 26,590,132 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001008566 (Get FASTA)   NCBI Sequence Viewer  
  NP_001349851 (Get FASTA)   NCBI Sequence Viewer  
  NP_001349852 (Get FASTA)   NCBI Sequence Viewer  
  NP_003586 (Get FASTA)   NCBI Sequence Viewer  
  XP_024308062 (Get FASTA)   NCBI Sequence Viewer  
  XP_047297505 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC34296 (Get FASTA)   NCBI Sequence Viewer  
  AAC36061 (Get FASTA)   NCBI Sequence Viewer  
  AAH01057 (Get FASTA)   NCBI Sequence Viewer  
  AAH17509 (Get FASTA)   NCBI Sequence Viewer  
  BAG51969 (Get FASTA)   NCBI Sequence Viewer  
  BAG52071 (Get FASTA)   NCBI Sequence Viewer  
  BAH14212 (Get FASTA)   NCBI Sequence Viewer  
  CAA06906 (Get FASTA)   NCBI Sequence Viewer  
  CAB66558 (Get FASTA)   NCBI Sequence Viewer  
  CAF85772 (Get FASTA)   NCBI Sequence Viewer  
  CAF86406 (Get FASTA)   NCBI Sequence Viewer  
  CAG30483 (Get FASTA)   NCBI Sequence Viewer  
  CAG38559 (Get FASTA)   NCBI Sequence Viewer  
  CBX47428 (Get FASTA)   NCBI Sequence Viewer  
  CBX47429 (Get FASTA)   NCBI Sequence Viewer  
  EAW59726 (Get FASTA)   NCBI Sequence Viewer  
  EAW59727 (Get FASTA)   NCBI Sequence Viewer  
  EAW59728 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000339813
  ENSP00000339813.4
  ENSP00000381180
  ENSP00000381180.2
  ENSP00000385192.1
  ENSP00000400357.2
  ENSP00000401134.1
  ENSP00000403758.1
  ENSP00000403875.1
  ENSP00000414809.1
  ENSP00000416791.1
GenBank Protein O60704 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_003586   ⟸   NM_003595
- Peptide Label: isoform 1
- UniProtKB: Q6FI98 (UniProtKB/Swiss-Prot),   B3KQA7 (UniProtKB/Swiss-Prot),   Q9H0V4 (UniProtKB/Swiss-Prot),   O60704 (UniProtKB/Swiss-Prot),   B7Z976 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001008566   ⟸   NM_001008566
- Peptide Label: isoform 1
- UniProtKB: Q6FI98 (UniProtKB/Swiss-Prot),   B3KQA7 (UniProtKB/Swiss-Prot),   Q9H0V4 (UniProtKB/Swiss-Prot),   O60704 (UniProtKB/Swiss-Prot),   B7Z976 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024308062   ⟸   XM_024452294
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001349851   ⟸   NM_001362922
- Peptide Label: isoform 1
- UniProtKB: Q6FI98 (UniProtKB/Swiss-Prot),   O60704 (UniProtKB/Swiss-Prot),   B3KQA7 (UniProtKB/Swiss-Prot),   Q9H0V4 (UniProtKB/Swiss-Prot),   B7Z976 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001349852   ⟸   NM_001362923
- Peptide Label: isoform 2
Ensembl Acc Id: ENSP00000381180   ⟸   ENST00000398110
Ensembl Acc Id: ENSP00000414809   ⟸   ENST00000450022
Ensembl Acc Id: ENSP00000401134   ⟸   ENST00000453117
Ensembl Acc Id: ENSP00000416791   ⟸   ENST00000440953
Ensembl Acc Id: ENSP00000400357   ⟸   ENST00000454778
Ensembl Acc Id: ENSP00000339813   ⟸   ENST00000338754
Ensembl Acc Id: ENSP00000385192   ⟸   ENST00000403880
Ensembl Acc Id: ENSP00000403875   ⟸   ENST00000442495
Ensembl Acc Id: ENSP00000403758   ⟸   ENST00000445720
RefSeq Acc Id: XP_047297505   ⟸   XM_047441549
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O60704-F1-model_v2 AlphaFold O60704 1-377 view protein structure

Promoters
RGD ID:6851656
Promoter ID:EP73630
Type:initiation region
Name:HS_TPST2
Description:Tyrosylprotein sulfotransferase 2.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 362225,316,069 - 25,316,129EPD
RGD ID:6800430
Promoter ID:HG_KWN:42140
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000320820,   OTTHUMT00000320823,   OTTHUMT00000320824,   OTTHUMT00000320825
Position:
Human AssemblyChrPosition (strand)Source
Build 362225,316,076 - 25,316,576 (-)MPROMDB
RGD ID:13603568
Promoter ID:EPDNEW_H27968
Type:initiation region
Name:TPST2_2
Description:tyrosylprotein sulfotransferase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H27969  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382226,565,341 - 26,565,401EPDNEW
RGD ID:13603570
Promoter ID:EPDNEW_H27969
Type:initiation region
Name:TPST2_1
Description:tyrosylprotein sulfotransferase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H27968  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382226,590,103 - 26,590,163EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:12021 AgrOrtholog
COSMIC TPST2 COSMIC
Ensembl Genes ENSG00000128294 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000338754 ENTREZGENE
  ENST00000338754.9 UniProtKB/Swiss-Prot
  ENST00000398110 ENTREZGENE
  ENST00000398110.6 UniProtKB/Swiss-Prot
  ENST00000403880.5 UniProtKB/Swiss-Prot
  ENST00000440953.5 UniProtKB/TrEMBL
  ENST00000442495.5 UniProtKB/TrEMBL
  ENST00000445720.1 UniProtKB/TrEMBL
  ENST00000450022.1 UniProtKB/TrEMBL
  ENST00000453117.1 UniProtKB/TrEMBL
  ENST00000454778.6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000128294 GTEx
HGNC ID HGNC:12021 ENTREZGENE
Human Proteome Map TPST2 Human Proteome Map
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:8459 UniProtKB/Swiss-Prot
NCBI Gene 8459 ENTREZGENE
OMIM 603126 OMIM
PANTHER PROTEIN-TYROSINE SULFOTRANSFERASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12788 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sulfotransfer_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA36700 PharmGKB
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B1AHJ5_HUMAN UniProtKB/TrEMBL
  B1AHJ6_HUMAN UniProtKB/TrEMBL
  B1AHJ7_HUMAN UniProtKB/TrEMBL
  B1AHJ8_HUMAN UniProtKB/TrEMBL
  B1AHJ9_HUMAN UniProtKB/TrEMBL
  B1AHK0_HUMAN UniProtKB/TrEMBL
  B3KQA7 ENTREZGENE
  B7Z976 ENTREZGENE, UniProtKB/TrEMBL
  O60704 ENTREZGENE
  Q6FI98 ENTREZGENE
  Q9H0V4 ENTREZGENE
  TPST2_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary B3KQA7 UniProtKB/Swiss-Prot
  Q6FI98 UniProtKB/Swiss-Prot
  Q9H0V4 UniProtKB/Swiss-Prot