| 1625156 | Tomt | transmembrane O-methyltransferase | Enables catechol O-methyltransferase activity. Involved in several processes, including auditory receptor cell development; catecholamine catabolic process; and positive regulation of protein import. Located in apical part of cell and endoplasmic reticulum. Used to study autosomal recessive nonsyndr omic deafness 63. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 63. Orthologous to several human genes including LRTOMT (leucine rich transmembrane and O-methyltransferase domain containing). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 101549010 | 101555572 | Mouse | 99 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 41410878 | TOMT | transmembrane O-methyltransferase | This gene encodes a catechol-O-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to a hydroxyl group of catechols and is essential for auditory and vestibular function. Mutations in this gene have been associated with nonsyndromic deafness. Readthrough tran scription is observed across this gene and the adjacent leucine-rich repeat containing 51 gene. A third locus (GeneID:220074) is defined to represent the readthrough transcripts. [provided by RefSeq, Feb 2021] | 11 | 72105924 | 72109596 | Human | 17 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 626172202 | tomt | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18737734 | TOMT | transmembrane O-methyltransferase | ENCODES a protein that exhibits catechol O-methyltransferase activity (inferred); methyltransferase activity (inferred); O-methyltransferase activity (inferred); INVOLVED IN auditory receptor cell development (inferred); catecholamine catabolic process (inferred); catecholamine metabolic process (in ferred); FOUND IN apical part of cell (inferred); cytoplasm (inferred); endoplasmic reticulum (inferred) | | | | Green Monkey | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13937075 | TOMT | transmembrane O-methyltransferase | INTERACTS WITH deoxynivalenol | | | | Pig | 1 | symbol | gene, protein-coding |
| 153002978 | TOMT | transmembrane O-methyltransferase | ENCODES a protein that exhibits catechol O-methyltransferase activity (inferred); methyltransferase activity (inferred); O-methyltransferase activity (inferred); INVOLVED IN auditory receptor cell development (inferred); catecholamine catabolic process (inferred); catecholamine metabolic process (in ferred); FOUND IN apical part of cell (inferred); cytoplasm (inferred); endoplasmic reticulum (inferred) | | | | Pig | 21 | symbol | gene, protein-coding |
| 626183739 | tomt | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626179608 | tomt | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18934705 | Tomt | transmembrane O-methyltransferase | ENCODES a protein that exhibits catechol O-methyltransferase activity (inferred); methyltransferase activity (inferred); O-methyltransferase activity (inferred); INVOLVED IN catecholamine catabolic process (inferred); catecholamine metabolic process (inferred); developmental process (inferred); FOUN D IN endoplasmic reticulum (inferred) | | | | Naked Mole-Rat | 14 | symbol , old_gene_name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1561509 | Lrtomt | leucine rich transmembrane and O-methyltransferase domain containing | ENCODES a protein that exhibits catechol O-methyltransferase activity (ortholog); INVOLVED IN auditory receptor cell development (ortholog); catecholamine catabolic process (ortholog); positive regulation of protein import (ortholog); ASSOCIATED WITH autosomal recessive nonsyndromic deafness (orthol og); autosomal recessive nonsyndromic deafness 63 (ortholog); genetic disease (ortholog); FOUND IN apical part of cell (ortholog); cytoplasm (ortholog); endoplasmic reticulum (ortholog); INTERACTS WITH bisphenol A; furan; gentamycin | 1 | 165678654 | 165680703 | Rat | 81 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1602965 | LRTOMT | leucine rich transmembrane and O-methyltransferase domain containing | This locus represents naturally occurring readthrough transcription between the neighboring LRRC51 (leucine-rich repeat containing 51) and TOMT (transmembrane O-methyltransferase) genes on chromosome 11. The readthrough transcript encodes a fusion protein that s hares sequence identity with each individual gene product. Multiple reports implicate mutations in this gene in nonsyndromic deafness.[provided by RefSeq, Feb 2021] | 11 | 72080850 | 72110782 | Human | 80 | symbol , COSMIC , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 41410865 | LRRC51 | leucine rich repeat containing 51 | This gene belongs to the leucine-rich repeat containing family. The encoded protein contains a transmembrane domain and two leucine-rich repeat domains. Unlike in mouse and other mammals, readthrough transcription is observed in primates between this gene and the adjacent transmembrane O-methyltrans ferase (Tomt) gene. Previously, this locus was annotated as a single gene representing the readthrough transcripts as well as the two different transcript species that encoded different proteins. It has since been split into three genes, including the two stand-alone genes and a third gene representing the readthrough transcription. [provided by RefSeq, Feb 2022] | 11 | 72080850 | 72096895 | Human | 52 | description | gene, protein-coding, REVIEWED [RefSeq] |
