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Gene: Tomt (transmembrane O-methyltransferase) Mus musculus
Analyze
Symbol:
Tomt
Name:
transmembrane O-methyltransferase
RGD ID:
1625156
MGI Page
MGI
Description:
Enables catechol O-methyltransferase activity. Involved in several processes, including auditory receptor cell development; catecholamine catabolic process; and positive regulation of protein import. Located in apical part of cell and endoplasmic reticulum. Used to study autosomal recessive nonsyndromic deafness 63. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 63. Orthologous to several human genes including LRTOMT (leucine rich transmembrane and O-methyltransferase domain containing) and TOMT (transmembrane O-methyltransferase).
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
catechol O-methyltransferase 2; catechol-O-methyltransferase 2; Comt; Comt2; F930017I19Rik; mTOMT; transmembrane O-methyltransferase homolog
RGD Orthologs
Alliance Genes
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
LRTOMT (leucine rich transmembrane and O-methyltransferase domain containing)
HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, OMA, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Lrtomt (leucine rich transmembrane and O-methyltransferase domain containing)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
LOC100967430 (leucine-rich repeat-containing protein 51)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
LOC106560171 (transmembrane O-methyltransferase)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
TOMT (transmembrane O-methyltransferase)
HGNC
Ensembl, HGNC, Inparanoid, OMA, OrthoDB, Panther
Homo sapiens (human):
LRRC51 (leucine rich repeat containing 51)
HGNC
OrthoDB, OrthoMCL
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Lrtomt (leucine rich transmembrane and O-methyltransferase domain containing)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Homo sapiens (human):
LRTOMT (leucine rich transmembrane and O-methyltransferase domain containing)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
tomt (transmembrane O-methyltransferase)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Homo sapiens (human):
LRRC51 (leucine rich repeat containing 51)
Alliance
DIOPT (HGNC)
Homo sapiens (human):
TOMT (transmembrane O-methyltransferase)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Related Pseudogenes:
Gm36096
Latest Assembly:
GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 7 101,549,010 - 101,555,572 (-) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 7 101,547,577 - 101,555,566 (-) Ensembl GRCm39 Ensembl GRCm38 7 101,899,803 - 101,906,407 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 7 101,898,370 - 101,906,359 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 7 109,048,317 - 109,054,873 (-) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 7 109,048,317 - 109,054,873 (-) NCBI MGSCv36 mm8 Celera 7 102,274,130 - 102,280,686 (-) NCBI Celera Cytogenetic Map 7 E2 NCBI cM Map 7 54.68 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Disease Annotations - ClinVar
Imported Disease Annotations - CTD
Imported Disease Annotations - MGI
Imported Disease Annotations - OMIM
References
Additional References at PubMed
Genomics
Comparative Map Data
Tomt (Mus musculus - house mouse)
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 7 101,549,010 - 101,555,572 (-) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 7 101,547,577 - 101,555,566 (-) Ensembl GRCm39 Ensembl GRCm38 7 101,899,803 - 101,906,407 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 7 101,898,370 - 101,906,359 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 7 109,048,317 - 109,054,873 (-) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 7 109,048,317 - 109,054,873 (-) NCBI MGSCv36 mm8 Celera 7 102,274,130 - 102,280,686 (-) NCBI Celera Cytogenetic Map 7 E2 NCBI cM Map 7 54.68 NCBI
LRTOMT (Homo sapiens - human)
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 11 72,080,850 - 72,110,782 (+) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 11 72,080,331 - 72,110,782 (+) Ensembl GRCh38 hg38 GRCh38 GRCh37 11 71,791,896 - 71,821,828 (+) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 11 71,469,553 - 71,485,589 (+) NCBI NCBI36 Build 36 hg18 NCBI36 Celera 11 69,093,343 - 69,123,775 (+) NCBI Celera Cytogenetic Map 11 q13.4 NCBI HuRef 11 68,084,985 - 68,115,422 (+) NCBI HuRef CHM1_1 11 71,675,200 - 71,705,636 (+) NCBI CHM1_1 T2T-CHM13v2.0 11 72,007,754 - 72,037,672 (+) NCBI T2T-CHM13v2.0
Lrtomt (Rattus norvegicus - Norway rat)
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 1 165,678,654 - 165,680,703 (-) NCBI GRCr8 mRatBN7.2 1 156,266,655 - 156,268,704 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 1 156,266,655 - 156,268,704 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 1 164,250,824 - 164,252,873 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 1 171,430,918 - 171,432,967 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 1 164,308,366 - 164,310,415 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 1 166,985,468 - 166,989,681 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 1 166,986,013 - 166,988,062 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 1 173,176,767 - 173,178,816 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 1 159,362,010 - 159,364,059 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 Celera 1 154,340,313 - 154,342,362 (-) NCBI Celera Cytogenetic Map 1 q32 NCBI
LOC100967430 (Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 9 73,030,257 - 73,059,366 (+) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 11 74,072,707 - 74,101,555 (+) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 11 67,160,599 - 67,189,746 (+) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 11 70,384,068 - 70,400,764 (+) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl 11 70,392,081 - 70,412,641 (+) Ensembl panpan1.1 panPan2
LOC106560171 (Canis lupus familiaris - dog)
Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 21 25,975,547 - 25,981,097 (-) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 21 25,743,343 - 25,751,089 (-) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 21 26,182,525 - 26,190,272 (-) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 21 26,184,399 - 26,189,875 (-) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 21 25,973,788 - 25,981,524 (-) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 21 26,189,907 - 26,197,654 (-) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 21 26,091,538 - 26,099,285 (-) NCBI UU_Cfam_GSD_1.0
QTLs in Region (GRCm39)
25314307 Mlh1fc2_m MLH1 foci count 2 (mouse) 7 6502999 133501729 Mouse 12792978 Fbmd3_m femoral bone mineral density 3, females only (mouse) 7 7050288 142367832 Mouse 10412199 Sst2_m susceptibility to tuberculosis 2 (mouse) Not determined 7 18728794 119485380 Mouse 1301158 Eae4_m susceptibility to experimental allergic encephalomyelitis 4 (mouse) Not determined 7 19147398 141919804 Mouse 26884404 Huml1_m humerus length 1, 5 week (mouse) 7 30199425 108999207 Mouse 1301082 Bbaa16_m B.burgdorferi-associated arthritis 16 (mouse) Not determined 7 36280015 116416877 Mouse 1300791 Abbp3_m A/J and C57BL/6 blood pressure 3 (mouse) Not determined 7 39673887 103510010 Mouse 10043926 Bw1n_m body weight 1 in NSY (mouse) Not determined 7 45161966 118693530 Mouse 13208555 Lgth10_m body length 10 (mouse) 7 51649748 125599172 Mouse 27226751 Femd5_m femur midshaft diameter 5, 10 week (mouse) 7 53249748 143153737 Mouse 25823170 Hrsq7_m host response to SARS QTL 7, log titer (mouse) 7 54819589 116822815 Mouse 27226778 Femd11_m femur midshaft diameter 11, 16 week (mouse) 7 56949748 134001729 Mouse 26884408 Bzwq13_m bi-zygomatic width QTL 13, 16 week (mouse) 7 61749748 121399223 Mouse 27095916 Scvln15_m sacral vertebrae length 2, 16 week (mouse) 7 61749748 123699223 Mouse 25314305 Vmm6_m variable multisystem mineralization 6, eye (mouse) 7 61849748 102749207 Mouse 26884440 Sklq4_m skull length QTL 4, 5 week (mouse) 7 65249748 126499172 Mouse 26884418 Bzwq7_m bi-zygomatic width QTL 7, 10 week (mouse) 7 67849748 105449207 Mouse 27226715 Metcl3_m metatarsal-calcaneal length 3, 5 week (mouse) 7 67849748 119499223 Mouse 26884444 Sklq8_m skull length QTL 8, 10 week (mouse) 7 67849748 124199223 Mouse 26884451 Sklq14_m skull length QTL 14, 16 week (mouse) 7 67849748 124999172 Mouse 1300654 Bomd1_m bone mineral density 1 (mouse) Not determined 7 68365595 102365702 Mouse 27095907 Scvln4_m sacral vertebrae length 2, 5 week (mouse) 7 69949748 120499223 Mouse 1301155 Bpq7_m blood pressure QTL 7 (mouse) Not determined 7 70143137 104143379 Mouse 10043973 Obq29_m obesity QTL 29 (mouse) Not determined 7 72263372 106263372 Mouse 27095910 Pglq13_m pelvic girdle length QTL 13, 16 week (mouse) 7 73049748 125699172 Mouse 27095933 Ulnl3_m ulna length 3, 5 week (mouse) 7 73149748 143153737 Mouse 11553869 Stmm2b_m skin tumor modifier of MSM 2a (mouse) 7 73725965 107725965 Mouse 27226745 Metcl9_m metatarsal-calcaneal length 9, 10 week (mouse) 7 74849748 122199223 Mouse 27226781 Tibl3_m tibia length 3, 5 week (mouse) 7 74849748 122199223 Mouse 1301566 Adip3_m adiposity 3 (mouse) Not determined 7 75394215 109394346 Mouse 14746989 Manh62_m mandible shape 62 (mouse) 7 75742528 109742528 Mouse 26884398 Humsd6_m humerus midshaft diameter 6, 16 week (mouse) 7 78649748 136901729 Mouse 10412110 Cctq1_m central corneal thickness QTL 1 (mouse) Not determined 7 80551681 114551791 Mouse 4142500 Morq1_m modifier of Rs1 QTL 1 (mouse) Not determined 80551681 114551791 Mouse 27095930 Ulnl10_m ulna length 10, 16 week (mouse) 7 80849748 126699172 Mouse 27095923 Pglq3_m pelvic girdle length QTL 3, 5 week (mouse) 7 81249748 124199223 Mouse 27095903 Scvln10_m sacral vertebrae length 2, 10 week (mouse) 7 81449748 126499172 Mouse 27226765 Tibl18_m tibia length 18, 16 week (mouse) 7 81849748 126499172 Mouse 27226763 Feml20_m femur length 20, 16 week (mouse) 7 85049208 124199223 Mouse 1301997 Cia7_m collagen induced arthritis QTL 7 (mouse) Not determined 7 85365595 112533819 Mouse 1301647 Elpt_m elevated leptin (mouse) Not determined 7 86500186 120500329 Mouse 1301188 Heal6_m wound healing/regeneration 6 (mouse) Not determined 7 87043932 121044066 Mouse 1302062 Stheal6_m soft tissue heal 6 (mouse) Not determined 7 87043932 121044066 Mouse 13463473 Hbbcq4_m hemoglobin concentration QTL 4 (mouse) 7 87043932 121044066 Mouse 1301781 Capsq3_m capsaicin sensitivity related QTL 3 (mouse) Not determined 7 87143137 119485380 Mouse 27226769 Tibl12_m tibia length 12, 10 week (mouse) 7 87249208 126499172 Mouse 27226790 Feml15_m femur length 15, 10 week (mouse) 7 87249208 126499172 Mouse 27095929 Pglq8_m pelvic girdle length QTL 8, 10 week (mouse) 7 87849208 108099207 Mouse 1357664 Nba3_m New Zealand Black autoimmunity 3 (mouse) Not determined 7 91482996 125483156 Mouse 1301937 Skull10_m skull morphology 10 (mouse) Not determined 7 91482996 125483156 Mouse 13464255 Ifvrq2_m influenza virus resistance QTL 2 (mouse) 7 92500698 106455693 Mouse 1300528 Ssial3_m susceptibility to sialadenitis 3 (mouse) Not determined 7 93391848 127392041 Mouse 1301478 Eae26_m susceptibility to experimental allergic encephalomyelitis 26 (mouse) Not determined 7 98164922 132165010 Mouse 13524850 Asrq7_m acoustic startle response 7 (mouse) 7 98394974 132394974 Mouse 10412104 Tons2_m tongue size 2 (mouse) Not determined 7 99837716 133837716 Mouse 11039524 Tbbr3_m Trypanosoma brucei brucei response 3 (mouse) 7 100750722 134750843 Mouse 1301447 Fembm3_m femoral bone morphometry 3 (mouse) Not determined 7 100993261 134993342 Mouse