| 1308455 | Tmx1 | thioredoxin-related transmembrane protein 1 | ENCODES a protein that exhibits disulfide oxidoreductase activity (ortholog); enzyme inhibitor activity (ortholog); protein disulfide isomerase activity (ortholog); INVOLVED IN negative regulation of platelet aggregation (ortholog); negative regulation of triglyceride biosynthetic process (ortholog) ; positive regulation of ERAD pathway (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); mitochondria-associated endoplasmic reticulum membrane contact site (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol | 6 | 94696699 | 94707751 | Rat | 128 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1318232 | TMX1 | thioredoxin related transmembrane protein 1 | This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembran e domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The mature membrane-bound protein can both oxidize and reduce disulfide bonds and acts selectively on membrane-associated polypeptides. [provided by RefSeq, Jan 2017] | 14 | 51240247 | 51257655 | Human | 116 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1318233 | Tmx1 | thioredoxin-related transmembrane protein 1 | Enables protein disulfide isomerase activity. Involved in negative regulation of platelet aggregation. Predicted to be located in extracellular region and mitochondrial membrane. Predicted to be active in endoplasmic reticulum membrane and mitochondria-associated endoplasmic reticulum membrane conta ct site. Orthologous to human TMX1 (thioredoxin related transmembrane protein 1). [provided by Alliance of Genome Resources, Apr 2025] | 12 | 70499928 | 70514398 | Mouse | 135 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8830705 | Tmx1 | thioredoxin related transmembrane protein 1 | ENCODES a protein that exhibits disulfide oxidoreductase activity (ortholog); enzyme inhibitor activity (ortholog); protein disulfide isomerase activity (ortholog); INVOLVED IN negative regulation of platelet aggregation (ortholog); negative regulation of triglyceride biosynthetic process (ortholog) ; positive regulation of ERAD pathway (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); mitochondria-associated endoplasmic reticulum membrane contact site (ortholog) | NW_004955409 | 11708867 | 11722205 | Chinchilla | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11702977 | TMX1 | thioredoxin related transmembrane protein 1 | ENCODES a protein that exhibits disulfide oxidoreductase activity (inferred); enzyme inhibitor activity (inferred); isomerase activity (inferred); INVOLVED IN negative regulation of platelet aggregation (inferred); negative regulation of triglyceride biosynthetic process (inferred); positive regulat ion of ERAD pathway (inferred); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog) | 14 | 31844418 | 31861911 | Bonobo | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12110397 | TMX1 | thioredoxin related transmembrane protein 1 | ENCODES a protein that exhibits disulfide oxidoreductase activity (inferred); enzyme inhibitor activity (inferred); isomerase activity (inferred); INVOLVED IN negative regulation of platelet aggregation (inferred); negative regulation of triglyceride biosynthetic process (inferred); positive regulat ion of ERAD pathway (inferred); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog) | 8 | 27541407 | 27556058 | Dog | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12729337 | Tmx1 | thioredoxin related transmembrane protein 1 | ENCODES a protein that exhibits disulfide oxidoreductase activity (inferred); enzyme inhibitor activity (inferred); isomerase activity (inferred); INVOLVED IN negative regulation of platelet aggregation (inferred); negative regulation of triglyceride biosynthetic process (inferred); positive regulat ion of ERAD pathway (inferred); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog) | NW_004936495 | 14432971 | 14447380 | Squirrel | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13938371 | TMX1 | thioredoxin related transmembrane protein 1 | ENCODES a protein that exhibits disulfide oxidoreductase activity (inferred); enzyme inhibitor activity (inferred); isomerase activity (inferred); INVOLVED IN negative regulation of platelet aggregation (inferred); negative regulation of triglyceride biosynthetic process (inferred); positive regulat ion of ERAD pathway (inferred); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog) | | | | Pig | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18481372 | TMX1 | thioredoxin related transmembrane protein 1 | ENCODES a protein that exhibits disulfide oxidoreductase activity (inferred); enzyme inhibitor activity (inferred); isomerase activity (inferred); INVOLVED IN negative regulation of platelet aggregation (inferred); negative regulation of triglyceride biosynthetic process (inferred); positive regulat ion of ERAD pathway (inferred); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog) | | | | Green Monkey | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625950674 | Tmx1 | thioredoxin related transmembrane protein 1 | ENCODES a protein that exhibits disulfide oxidoreductase activity (ortholog); enzyme inhibitor activity (ortholog); protein disulfide isomerase activity (ortholog); INVOLVED IN negative regulation of platelet aggregation (ortholog); negative regulation of triglyceride biosynthetic process (ortholog) ; positive regulation of ERAD pathway (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); mitochondria-associated endoplasmic reticulum membrane contact site (ortholog) | | | | Black Rat | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18918910 | Tmx1 | thioredoxin related transmembrane protein 1 | ENCODES a protein that exhibits disulfide oxidoreductase activity (inferred); enzyme inhibitor activity (inferred); isomerase activity (inferred); INVOLVED IN negative regulation of platelet aggregation (inferred); negative regulation of triglyceride biosynthetic process (inferred); positive regulat ion of ERAD pathway (inferred); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog) | | | | Naked Mole-Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245753 | tmx1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155251388 | tmx1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155253878 | tmx1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 38670064 | TMX1P1 | TMX1 pseudogene 1 | | 7 | 39567618 | 39570231 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16565814 | TMX1P2 | TMX1 pseudogene 2 | | 8 | 69794022 | 69800242 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |