ENCODES a protein that exhibits chromatin binding; cis-regulatory region sequence-specific DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN response to xenobiotic stimulus; aorta morphogenesis (ortholog); collecting duct develop
ment (ortholog); ASSOCIATED WITH angle-closure glaucoma (ortholog); Body Weight (ortholog); Char syndrome (ortholog); FOUND IN nucleus (ortholog); INTERACTS WITH 1,2-dimethylhydrazine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including artery morphogenesis; kidney development; and limb morphogenesis. Acts upstream of with a nega
tive effect on negative regulation of apoptotic process. Acts upstream of or within several processes, including negative regulation of neuron apoptotic process; positive regulation of transcription by RNA polymerase II; and sympathetic nervous system development. Located in nucleus. Is expressed in several structures, including genitourinary system; jaw; nervous system; sensory organ; and skin. Used to study Char syndrome; angle-closure glaucoma; and patent ductus arteriosus. Human ortholog(s) of this gene implicated in Char syndrome and patent ductus arteriosus. Orthologous to human TFAP2B (transcription factor AP-2 beta). [provided by Alliance of Genome Resources, Jul 2025]