| 620523 | Tcf21 | transcription factor 21 | ENCODES a protein that exhibits bHLH transcription factor binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); INVOLVED IN embryonic digestive tract morphogenesis; gland development; Sertoli cell differentiation; ASSOCIATED WITH coronary artery disease (ortholog); Paroxysmal Atrial Fibrillation (ortholog); ventricular septal defect (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); transcription regulator complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 4-tert-Octylphenol | 1 | 24520499 | 24523358 | Rat | 197 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1351692 | TCF21 | transcription factor 21 | TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal a nd glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] | 6 | 133889113 | 133895537 | Human | 187 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1552041 | Tcf21 | transcription factor 21 | Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and E-box binding activity. Involved in several processes, including metanephros development; regulation of transcription by RNA polymerase I I; and skeletal muscle organ development. Acts upstream of or within several processes, including lung development; nephron development; and sex determination. Part of transcription regulator complex. Is expressed in several structures, including embryo mesenchyme; genitourinary system; gut; heart and pericardium; and respiratory system. Human ortholog(s) of this gene implicated in coronary artery disease and ventricular septal defect. Orthologous to human TCF21 (transcription factor 21). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 22693162 | 22696042 | Mouse | 283 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8930534 | Tcf21 | transcription factor 21 | ENCODES a protein that exhibits bHLH transcription factor binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); b ranching involved in ureteric bud morphogenesis (ortholog); branchiomeric skeletal muscle development (ortholog); ASSOCIATED WITH coronary artery disease (ortholog); Paroxysmal Atrial Fibrillation (ortholog); ventricular septal defect (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); transcription regulator complex (ortholog) | NW_004955439 | 2617562 | 2620613 | Chinchilla | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11790976 | TCF21 | transcription factor 21 | ENCODES a protein that exhibits bHLH transcription factor binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN animal organ morphogenesis (ortholog); branching involved in ureteric bud morphogenesis (ortholog); b ronchiole development (ortholog); ASSOCIATED WITH coronary artery disease (ortholog); Paroxysmal Atrial Fibrillation (ortholog); ventricular septal defect (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); transcription regulator complex (inferred) | 6 | 131656582 | 131662983 | Bonobo | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12311846 | TCF21 | transcription factor 21 | ENCODES a protein that exhibits bHLH transcription factor binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN animal organ morphogenesis (ortholog); branching involved in ureteric bud morphogenesis (ortholog); b ronchiole development (ortholog); ASSOCIATED WITH coronary artery disease (ortholog); Paroxysmal Atrial Fibrillation (ortholog); ventricular septal defect (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); transcription regulator complex (inferred) | 1 | 26856281 | 26859654 | Dog | 54 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12721241 | Tcf21 | transcription factor 21 | ENCODES a protein that exhibits bHLH transcription factor binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN animal organ morphogenesis (ortholog); branching involved in ureteric bud morphogenesis (ortholog); b ronchiole development (ortholog); ASSOCIATED WITH coronary artery disease (ortholog); Paroxysmal Atrial Fibrillation (ortholog); ventricular septal defect (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); transcription regulator complex (inferred) | NW_004936560 | 1733903 | 1736895 | Squirrel | 54 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14024683 | TCF21 | transcription factor 21 | ENCODES a protein that exhibits bHLH transcription factor binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN animal organ morphogenesis (ortholog); branching involved in ureteric bud morphogenesis (ortholog); b ronchiole development (ortholog); ASSOCIATED WITH coronary artery disease (ortholog); Paroxysmal Atrial Fibrillation (ortholog); ventricular septal defect (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); transcription regulator complex (inferred) | | | | Pig | 69 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236810 | tcf21 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18913351 | Tcf21 | transcription factor 21 | ENCODES a protein that exhibits sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); branching involved in ureteric bud morphogenesis (ortholog); bronchiole development (ortholog); ASSOCIATED WITH coronary artery disease (ortholog); Paroxysmal Atrial Fibrillation (ortholog); ventricular septal defect (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Naked Mole-Rat | 53 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18786256 | TCF21 | transcription factor 21 | ENCODES a protein that exhibits bHLH transcription factor binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN animal organ morphogenesis (ortholog); branching involved in ureteric bud morphogenesis (ortholog); b ronchiole development (ortholog); ASSOCIATED WITH coronary artery disease (ortholog); Paroxysmal Atrial Fibrillation (ortholog); ventricular septal defect (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); transcription regulator complex (inferred) | | | | Green Monkey | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626043863 | Tcf21 | transcription factor 21 | ENCODES a protein that exhibits bHLH transcription factor binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); b ranching involved in ureteric bud morphogenesis (ortholog); branchiomeric skeletal muscle development (ortholog); ASSOCIATED WITH coronary artery disease (ortholog); Paroxysmal Atrial Fibrillation (ortholog); ventricular septal defect (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); transcription regulator complex (ortholog) | | | | Black Rat | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155246791 | tcf21.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155236811 | tcf21.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 8655759 | TARID | TCF21 antisense RNA inducing promoter demethylation | ASSOCIATED WITH dilated cardiomyopathy | 6 | 133502252 | 133889006 | Human | 1 | name | gene, ncrna, VALIDATED [RefSeq] |